Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake

... inhibitory effect of nitrite, possibly because of aerobic nitrite denitrification. • Nitrite inhibition of aerobic phosphate uptake is successfully expressed by the model including aerobic nitrite denitrification ... size of nitrite exposure and the size of inhibition. The obtained results are as follows; 1) Nitrite inhibits aerobic phosphate uptake of...

Ngày tải lên: 05/09/2013, 09:38

... activation of effector caspases. Mechanisms of inhibition of protein synthesis We have shown that TRAIL treatment causes both phosphorylation of eIF2a and dephosphorylation of 4E-BP1. The latter change ... Division of Basic Medical Sciences, St George’s, University of London, UK Members of the tumour necrosis factor-a (TNFa) fam- ily are well known as inhibitors of cell...

Ngày tải lên: 19/02/2014, 06:20

... (1991) Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation. ... include protection of lipid droplets against the activity of intracellular lipases such as hormone-sensitive lipase (HSL), inhibition of fatty acid oxidation (which wo...

Ngày tải lên: 23/03/2014, 10:21

... ate and extent of inhibition (Fig. 4 B). Inhibition by protein-derived peroxides was slower than that induced by the peptide peroxides at Fig. 4. Inhibition of glyceraldehyde-3 -phosphate dehydrogenase ... inactivation of G APDH being metal- ion independent, whereas inhibition of GR and LDH by H 2 O 2 occurs most rapidly in the presence of metal ions. It is proposed that th...

Ngày tải lên: 21/02/2014, 03:20

... with 55 mL of the same buffer, first alone and then with a 200 mL of a decreasing gradient of ammonium sul- phate in 20 mm Tris⁄ HCl buffer (pH 8.0) with a flow of 0.8 mLÆmin )1 . Fractions of 2.5 ... order to determine the type of inhibition and the K i using brassinin (0.10–0.40 mm) as a sub- strate in the presence of inhibitor (0.10, 0.20 and 0.40 mm). The kinetics of inhi...

Ngày tải lên: 18/02/2014, 14:20

... a molecular model of the methyltetra- hydrofolate-binding domain of the rat liver MetS was constructed. In the absence of a high-resolution struc- ture of the methyltetrahydrofolate-binding site ... result of this approach indicated the orienta- tion of 5-methyltetrahydrofolate in the MetS active site. Figure 5 shows the superimposed structures of DHPS and 5-methyltetrahydrofola...

Ngày tải lên: 19/02/2014, 05:20

... lysis) of the cell wall is an essential process for both cell viability and liberation of viru- lence factors. Inhibition of autolysis by excess cho- line might, in the first instance, seem to be of therapeutic ... inhibitor of the activity of LytA [23,24] and other CBPs [25]. Moreover, addition of an excess of choline to culture media inhibits daughter cell separ- ation and...

Ngày tải lên: 19/02/2014, 05:20

... involve- ment of substrate inhibition. [S] (µM) 020406080100 )s/.u.a( V 0.0 0.2 0.4 0.6 0.8 Fig. 3. Inhibition of the lethal factor (LF) protease by neomycin B: least-squares fit of the complete ... noncompetitive) can be explained in one of several ways. First, it is possible that neomycin B truly shows two different kinetic mechanisms of inhibition, depend- ing on the nature...

Ngày tải lên: 19/02/2014, 06:20

... value of ThT fluorescence intensity was taken as 100%. From these, for each reading of ThT fluores- cence the percentage of inhibition of the fibril growth was obtained. The percentage of inhibition ... 5 [5,6]. In the present series of experiments we compared fibrillation of stefin B wildtype (E31 isoform), of stefin B variant 2 (Y31 isoform) and the mutant P79S of the varian...

Ngày tải lên: 19/02/2014, 06:20

... molecular phenotypic effect of using this vector. This is the first report of the detection at the molecular level of the toxic effect of a DNA vector in P. falciparum. Although mechanisms of RNAi silencing ... first two steps of the pentose phosphate pathway [13]. The occurrence of large insertion sequences that differ with respect to their homologous proteins in other specie...

Ngày tải lên: 19/02/2014, 07:20