High frequency of epidermal growth factor receptor mutations in non small cell lung cancers in vietnam

... Coulter Inc., Fullerton, CA, USA) according to manufacturer instructions Multiplex PCR and primer extension analysis of mutations in EGFR-216 promoter region and exons 18, 19, 20, and 21 Multiplex PCR ... amount of work and time required With this method, -216 promoter region and exons 18-21 of the EGFR gene were amplified with multiplex PCR in a sing...

Ngày tải lên: 10/08/2014, 05:21

... expression of the MUC5AC mucin (a predominant airway mucin) gene Interaction of EGFR with its ligands led to EGFR tyrosine kinase phosphorylation, and a selective EGFR tyrosine kinase inhibitor ... virus-induced goblet-cell metaplasia in pathogen-free rats, developing mucin- containing cells did not incorporate [3H]thymidine, suggesting that cell mitosis was not involved in synthe...

Ngày tải lên: 12/08/2014, 18:20

... system may be one of the mechanisms responsible for drug -induced apoptosis in a variety of JNK activation is critical for AG1478 -induced apoptosis cancer cells of different histotype [51] Chang ... RA & Davis RJ (2000) Requirement of JNK for stress -induced activation of the cytochrome c-mediated death pathway Science 288, 870–874 JNK activation is...

Ngày tải lên: 18/02/2014, 13:20

... regulatory mechanism of MIG6 in relation to the EGFR mutation The present study is the first to show the association of MIG6 expression with the EGFR mutation in cancer MIG6 ⁄ RALT is known to be ... EGFR mutation and MIG6 expression T Nagashima et al Introduction Epidermal growth factor receptor (EGFR) is a membrane tyrosine kinase that is involved in t...

Ngày tải lên: 30/03/2014, 01:20

... Immunohistochemical staining intensity scores A) Meningiomas stained with anti-EGFR antisera showing negative staining B) 1+ staining C) 2+ staining D) 3+ staining Original magnification for ... Beguinot L, Macchia V: Epidermal growth factor receptor in human brain tumors J Endocrinol Invest 1992, 15(1):31-37 Johnson MD, Horiba M, Winnier AR, Artiaga CL: The epidermal growth...

Ngày tải lên: 09/08/2014, 09:20

... for studying rafts is interrupting rafts by changing the amount of cholesterol in cells, which includes increasing its amount by adding in extra cholesterol and extracting it by drug treatments ... thereby enabling the exposure of the ligand-binding pocket of domain L1 and L2 The dimerization arm in domain CR1 is known to facilitate the formation of dimers, which lead...

Ngày tải lên: 10/09/2015, 09:25

... signal-regulated kinases: association with epidermal growth factor receptor/ transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti -epidermal growth factor receptor ... transforming growth factor α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and nec...

Ngày tải lên: 09/08/2014, 10:20

... doi:10.1186/1748-717X-5-81 Cite this article as: Baba et al.: Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size Radiation Oncology ... S, Ogino H, Ito M: Estimation of errors associated with use of linear-quadratic formalism for evaluation of biologic equivalence...

Ngày tải lên: 09/08/2014, 09:20

... Nck [72] The binding of these proteins could prevent the interaction of the Ca2+ ⁄ CaM complex to the receptor if the CaMBD were occluded at least in part Nevertheless, the docking of these adaptor ... internalization and the subsequent degradation of the receptor in transfected human embryonic kidney cells [50] Direct regulation of the EGFR by CaM The dire...

Ngày tải lên: 06/03/2014, 09:22

... the epidermal growth factor (EGF) receptor ⁄ extracellular signalregulated kinase ⁄ and EGF receptor ⁄ Akt pathway for proliferation Mol Cancer Ther 3, 46 5–4 72 Amann J, Kalyankrishna S, Massion ... motility, and invasion It is also of great interest and importance to note that about one-third of the human lung cancer samples that we examined revealed significant downregulat...

Ngày tải lên: 07/03/2014, 00:20

... before the cells were washed and Hrs was immunoprecipitated from the lysate We chose to stimulate the cells with the growth factors for min, as the growth factor- stimulated phosphorylation of Hrs ... hypertonic media prevents the EGF-induced phosphorylation of Hrs This suggests that the phosphorylation of Hrs takes place on endosomes [4] As the activa...

Ngày tải lên: 17/03/2014, 11:20

... Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab (Herceptin) maintenance therapy in a woman: a case ... will influence whether a patient achieves long-lasting remission on maintenance trastuzumab therapy We also speculate that the...

Ngày tải lên: 11/08/2014, 02:22

... Nonaka Y, Okamoto M: Differential regulation of 3beta-hydroxysteroid dehydrogenase type II and 17alpha-hydroxylase/lyase P450 in human adrenocortical carcinoma cells by epidermal growth factor ... Hoek JB: Quantification of short term signaling by the epidermal growth factor receptor J Biol Chem 1999, 274:30169-30181 Terlau H, Seifert W: Influence of epidermal growth...

Ngày tải lên: 14/08/2014, 16:21

... Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer Cancer Sci 98, ... Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine k...

Ngày tải lên: 16/02/2014, 09:20

... compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig 1) Early clinical studies showed ... (2006) Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors Genes Dev...

Ngày tải lên: 16/02/2014, 09:20