... stained with hematoxylin and eosin (H&E) or safranin O to assess hyperplasia of synovial tissue, infiltration of leukocytes, and destruction of cartilage Each parameter was graded separately and ... signal-regulated kinase pathways are involved in osteoclast differentiation Bone 2002, 30:71-77 15 Nakamura I, Takahashi N, Sasaki T, Tanaka S, Udagawa N, Murakami H, Kimura K, Kabuyama Y, Kurokawa T, ... Moreover, daily administration of ZSTK474 ameliorated collagen-induced arthritis (CIA) in mice, remarkably reducing the migration of inflammatory cells and OCs in the synovial tissue Materials and methods...