... number of extraction schemes have been developed, but all are complex and not reliably yield usable quantities of BMP, as only to µg of BMPs are present in a kilogram of cortical bone Furthermore, ... inhibitory effects of the nonsteroidal anti-inflammatory drug ketorolac on fusion rate.21 Dose Response Using rhBMP-2 with a collagen carrier in a canine spinal fusion model, David et al22 showed a dosedependent ... including 58, 115, 230, 460, and 920 µg Histologically, abundant bone formation occurred in all specimens containing rhBMP-2 by months.24 The data from this study and the one using 2,300 µg of rhBMP-2...