Investigation of the role of microRNAs in spinocerebellar ataxia type 3

... 19 -33 Ataxia type (SCA1) Spinocerebellar Ataxia type (SCA2) Spinocerebellar Ataxia type (SCA3) Spinocerebellar Ataxia type (SCA6) calcium channel subunit Spinocerebellar ATXN7 Ataxin 4 -35 37 -30 6 ... interspersed by introns that are omitted in the ATXN3 mRNA (b) The initial exons code for the Josephin domain in the ATXN3 protein, the rest of the e...

Ngày tải lên: 26/11/2015, 10:00

... 1 AN INVESTIGATION INTO THE ROLE OF CHEMOKINES IN HAEMOPOIETIC STEM CELL QUIESCENCE Amy Sinclair BSc (hons), MRes Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy ... heavily involved in the production and regulation of all cell types in the biological system, including in haemopoiesis The identification of...

Ngày tải lên: 22/12/2014, 21:11

... as in embryonic carcinoma (EC) cells, which may have conserved roles in mammalian pluripotent stem cells (2) microRNAs expressed specifically in ESCs but not in other cells including EC cells These ... putative minimal promoter The number and precise sequences of the pre -microRNAs, their distance from the promoter and the polyadenylation sites, the regions flank...

Ngày tải lên: 12/09/2015, 08:16

... nevertheless popular and effective tools to improve students‟ English speaking ability ii STATEMENT OF AUTHORSHIP Title: INVESTIGATION INTO THE ROLE OF INTERACTIVE LEARNING, AIMED AT INCREASING K40 ... ROLE OF INTERACTIVE LEARNING, AIMED AT INCREASING K40 STUDENTS‟ ENGLISH SPEAKING ABILITY IN HANOI PEDAGOGICAL UNIVERSITY NUMBER 2 II Spo...

Ngày tải lên: 24/09/2015, 15:42

... deletion or loss -of- function mutations in the survival of motor neuron (SMN) protein results in SMA [12] Gemin and Gemin are shared components of SMN and miRNAcontaining ribonucleoprotein particles ... overexpression of miR-375 resulted in suppressed glucose-stimulated insulin secretion and its inhibition resulted in enhanced insulin secretion Myotrophin, a protein that...

Ngày tải lên: 20/06/2014, 07:20

... 15.69% in the alkalinity induced library The relatively lower percentage of 24 nt reads indicates that more kinds of miRNAs are involved in the response of G max to alkalinity compared with other stress ... complete profile of miRNAs in Glycine max Keyword: deep sequencing, Glycine max, microRNAs, stresses associated, miRNA Background Terrestrial plants face...

Ngày tải lên: 11/08/2014, 11:21

... Global analysis of microRNA target gene expression reveals the potential roles of microRNAs in maintaining tissue identity Zhenbao Yu* , Zhaofeng Jian, Shi-Hsiang Shen, Enrico Purisima, and Edwin ... its targets for their expression Theoretically, the tissues with low level of the expression of the targets of a miRNA are probably the tissues in...

Ngày tải lên: 14/08/2014, 16:20

... communicativeness - General evaluation - The teaching of listening skills - The teaching of speaking skills - The teaching of reading skills - The teaching of writing skills - The teaching of grammar ... Table 4.2) The lowest mean was 2.51, indicating that half of the students were not satisfied with the design of the textbook Indeed, 50% were not attracted...

Ngày tải lên: 28/03/2015, 10:36

... Unfortunately, the demand of banking employees is forecasted to be in the down –trend in the next few years According to the point of view of specialists in banking industry, many banks will cut off the employees ... services of banks (See more information about Vietnamese Banking Industry in Appendix A) Among many industries, banking industry is o...

Ngày tải lên: 01/06/2015, 20:09

... of occurrences in the test data for trigrams that appeared 10 times in training data Discounting by a single value is plausible in the case of similar train and test corpora, where the mean of ... this second point in constructing our language model, an advantage of our approach over subsampling is that we use our entire training corpus, and in so doing compromise betwee...

Ngày tải lên: 20/02/2014, 04:20

... the intervening dialogue renders the solution size determinate In out of the indeterminate antecedent AD+Os, our hypothesis is verified (see excerpt (1), where [35] is an AD+ with indeterminate ... exist to the set of constraint equations, each varl in the set of equations must have a solution For example, if instances of sofas are known for varsola, but every assignment of a va...

Ngày tải lên: 20/02/2014, 18:20

... et al (2005) A microRNA polycistron as a potential human oncogene Nature 435, 828–833 39 Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y & Takahashi ... this approach discriminates normal and neoplastic tissues in various cancer types, including CLL, breast cancer, glioblastoma, thyroid papillary carcinoma, hepatocellular carcinom...

Ngày tải lên: 16/03/2014, 01:20

... stages and the changes of these networks in disease and after application of a variety of therapeutic strategies Critically, 2172 the noninvasive imaging approach of miRNA generation and its activity ... monitoring the therapeutic potential of miRNAs in cancer Bioimaging of microRNA biogenesis The molecular mechanisms involved in miRNA generation are complex,...

Ngày tải lên: 16/03/2014, 01:20

... doi:10.1186/1556-276X-6-69 Cite this article as: Liu et al.: Investigation of cracks in GaN films grown by combined hydride and metal organic vapor-phase epitaxial method Nanoscale Research Letters 2011 ... stresses during metalorganic chemical vapor deposition of GaN on sapphire Appl Phys Lett 2005, 86:261907 Hoffman RW: In situ observation of coalescence-...

Ngày tải lên: 21/06/2014, 06:20

... classroom in FFL CHAPTER II: LITERATURE REVIEW/THEORITICAL FRAMEWORK 2.1 Definitions of Pair work and Group work Pair work -group work has been incorporated into language teaching and learning in most ... benefits of having students work in pairs or groups? Shown in Table Q13 In your opinion, what are the obstacles in the implementation of pair work an...

Ngày tải lên: 30/06/2014, 16:53