Study of the effect of transforming growth factor 1 on the gap junction protein connexin 43 in hepatic stellate cells

... remodeling has been investigated thoroughly in fibroblasts such as H-ras transformed NIH3T3 fibroblasts, mouse embryo fibroblasts and Swiss3T3 fibroblasts [145–148] In fibroblasts transformed by inducible expression ... review of < /b> the specific and integrated roles of < /b> small GTPases in the control < /b> and execution of < /b> the TGFb signaling pathway Interconnection between TGF...

Ngày tải lên: 07/03/2014, 01:20

... RT-PCR was performed as described previously [7] SeP and GAPDH transcripts were coamplified using gene-specific primers Quantitative analyses were performed using a phosphorimaging system and QUANTITY ... Takahashi, K (1999) Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase Isolation and enzymatic characterization of human selenop...

Ngày tải lên: 31/03/2014, 23:20

... in clinical settings [1] The definition of "benignity" concerning FL is wideaccepted [2] but conceptually difficult to maintain because the mechanisms, i.e., insulin resistance (IR), underlying ... look into the supposed "benignity" of FL and "progressivity" of NASH is to speculate about eventual differences/similarities in mechanisms between the two entities With this in mind...

Ngày tải lên: 18/06/2014, 15:20

... mice Effect of anti-inflammatory drugs on glia activation and vascular amyloid deposition Ibuprofen or pioglitazone treatments were started at months of age and continued for months Two reasons ... anti-inflammatory drugs started at months of age, soon after weaning, and was carried out for months Ibuprofen was purchased from Sigma, and pioglitazone, manufactured by Takeda Pharm...

Ngày tải lên: 19/06/2014, 22:20

... postoperative day to day Vessels were first noted on postoperative day As progressed, the Angiogenesis effects of nerve growth factor (NGF) on rat corneas 129 Fig Appearance of angiogenesis on day ... 1.0 ng of NGF group (Group 1.0), and the 5.0 ng of NGF group (Group 5.0) Data analysis The significant differences between groups were Angiogenesis effects o...

Ngày tải lên: 07/08/2014, 15:20

... [25,29], gonadotrophin [15] or steroid hormone [15] The present study investigated the effect of βME or EGF supplementation on the base of the stages of the estrus cycle of the ovaries, and demonstrated ... was only observed in the oocytes collected from the follicular stage In conclusion, supplementation of canine IVM medium with GSH-synt...

Ngày tải lên: 07/08/2014, 18:20

... Hanly JG, Isenberg DA, Kalunian K, Nived O, et al.: The reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic ... antibodies and nine (28%) had lupus anticoagulant TGF-β1 activation index: an in vitro measure of the in vivo efficiency of TGF-β1 activation To examine the ability of...

Ngày tải lên: 09/08/2014, 08:22

... significance The pre-defined pathways contained two variants of the TGFβ pathway (called 'TGF_Beta_Signaling _Pathway' and 'tgfbPathway') Both pathways were among the top 30 ranking pathways (out of 259) ... potency for further activation by the respective cytokines or growth factors, for example, transforming growth factor (TGF)β To enhance the significance of the a...

Ngày tải lên: 09/08/2014, 10:20

... presence of FGF2 In addition, the chemical pathways utilized by FGF2 to antagonize the activity of BMP7 were analyzed to gain a better understanding of the complex interplay of growth factors, cytokines, ... activation of the ERK mitogenactivated protein kinase and NF-κB pathways are involved in the inhibitory action of FGF2 on BMP7 signaling via activation of nogg...

Ngày tải lên: 09/08/2014, 10:23

... Coulter Inc., Fullerton, CA, USA) according to manufacturer instructions Multiplex PCR and primer extension analysis of mutations in EGFR-216 promoter region and exons 18, 19, 20, and 21 Multiplex PCR ... amount of work and time required With this method, -216 promoter region and exons 18-21 of the EGFR gene were amplified with multiplex PCR in a sing...

Ngày tải lên: 10/08/2014, 05:21

... wild type group These data determine the dose response nature of lung injury following exposure to bleomycin Lung fibrosis induced by 4500 IU bleomycin in the Trwild type group was a mild patchy ... (Tr+ and bleomycin vs Tr- WT and bleomycin; Tr+ and bleomycin vs Tr+; Tr+ vs Tr- WT and bleomycin) A high number of altered genes were found to be upregulated and dowwnregulated in...

Ngày tải lên: 11/08/2014, 08:21

... TGF-β1 in the urine of male rats after CYP were also significantly higher than the levels of active and total TGF-β1 in the urine of female rats, both at baseline and after CYP (ANOVA, Tukey post ... control rats collected at the same time point of the day The levels of NO2-/NO3- in the urine of CYP-treated female rats remained higher as compared to both CY...

Ngày tải lên: 11/08/2014, 08:22

... M Jr, Palioto DB: Effects of enamel matrix derivative and transforming growth factor-beta1 on human periodontal ligament fibroblasts J Clin Periodontol 2007, 34:514-522 Page of 14 Tokiyasu Y, ... et al.: Effects of enamel matrix derivative and transforming growth factor-b1 on human osteoblastic cells Head & Face Medicine 2011 7:13 Submit your next...

Ngày tải lên: 11/08/2014, 20:21

... These indicate that there is an increased amount of TGF expressed in the airways that could be involved in the airway wall remodelling of chronic cough This is supported by the findings of a ... activity Sections were incubated with the avidin/biotinylated peroxidase complex for 30 min, followed by chromogenic substrate diaminobenzidine for min, and then counterstained in haema...

Ngày tải lên: 12/08/2014, 14:20

... Cells during Liver Injury 1. 3 Transforming Growth Factor- 1 (TGF- 1) 1. 4 Gap Junction Protein - Connexin 43 1. 4 .1 Family of Connexins 1. 4.2 Connexin 43 in Hepatic Stellate Cells 1. 5 Zinc Finger ... of connexins into gap junctions The connexin protein consists of an amino acid chain containing transmembrane helices with the amino and ca...

Ngày tải lên: 16/10/2015, 11:58