Investigating functions of ERp29 in mesenchymal to epithelial transition (MET) and epithelial plasticity in breast cancer cells

... Surprisingly, however, the protein synthesis inhibitor cycloheximide did not abolish the induction, which suggested that GPR30 is directly regulated by progestins We were not able to locate any progestin ... expressed in MCF-7 cells relatively late, although in a progestindependent manner, we decided to investigate whether MAPK activation is responsible for GPR30 mRNA regulation by p...

Ngày tải lên: 24/03/2014, 00:21

... support the hypothesis that BRCA1 enhances TRAIL s ability to mediate apoptosis in breast cancer cell lines Discussion There is increasing interest in the association between hypoxia and BRCA1 ... induce apoptosis in breast cancer cells Therefore, we assessed the requirement for functional BRCA1 in TRAIL- stimulated apoptosis HCC1937 cells have...

Ngày tải lên: 30/03/2014, 03:20

... associated with induced expression of insulin-like growth factor binding protein-2 in the uterus and ovary and decreased expression of insulinlike growth factor binding protein-3 in the uterus These changes ... as DFMO retards the growth of the pancreas [101], but does not inhibit the secretory function of the exocrine part of the organ [102] The cellular func...

Ngày tải lên: 30/03/2014, 13:20

... impact of exercise training on QOL in breast cancer survivors The aim of this study was to assess the association between physical exercise and quality of life in a population of female breast cancer ... between exercise and quality of life in multiple myeloma cancer survivors Support Care Cancer 2004;12:780-8 Courneya KS, Friedenreich CM Physical...

Ngày tải lên: 08/08/2014, 16:23

... staining of STC-1 in tumor tissues of nude mice STC-1 was detected on the membrane of tumor cells (D) Immunohistochemical staining of PCNA in tumor tissues of nude mice PCNA was detected in the ... Signaling Technology, USA) at 1: 1000, and the anti-btubulin rat monoclonal antibody (Beyotime, China) at 1:1000 VEGF Assay VEGF content in tumor culture supernatants...

Ngày tải lên: 10/08/2014, 05:21

... article as: Niu et al.: Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells Journal of Experimental & Clinical Cancer Research 2011 30:28 ... rapamycin will result in some beneficial modulation of the cancer killing properties of docetaxel in lung cancer cells [20,21] To the best of...

Ngày tải lên: 10/08/2014, 10:21

... Nanyang Technological University, Singapore (Silver Best Poster Award) vi THE MECHANISTIC STUDIES OF THE ANTICANCER POTENTIAL OF ARTESUNATE IN HUMAN CANCER CELLS Table of Contents DECLARATION ... ART induced autophagy in human cervical cancer HeLa cells evidenced by the increase of autophagic flux In the search of the mechanisms for ART-induced...

Ngày tải lên: 09/09/2015, 08:16

... 44 2. 1 2. 1.1 2. 1 .2 2.1.3 2. 1.4 Materials Ligand and inhibitors Antibodies Cell-lines Fresh frozen clinical specimens 44 44 44 45 45 2. 2 2. 2.1 2. 2 .2 2 .2. 3 2. 2.4 2. 2.5 2. 2.6 2. 2.7 2. 2.8 2. 2.9 2. 2.10 ... REGULATION OF PP2A BY HER- 2/ neu 77 4.1 77 Overview 4 .2 4 .2. 1 4 .2. 2 4 .2. 3 4 .2. 4 Results 80 Inhibition of HER- 2/ neu signalling using AG...

Ngày tải lên: 11/09/2015, 10:06

... novel binding properties of some SAM domains, showing that roles of SAM domains are not restricted in mediating protein-protein interactions One surprising finding is that the SAM domains of translational ... called as “Arginine finger” In 11 RhoGAP-stimulating GTP hydrolysis, the long side chain of this arginine residue allows it to “dip” like a finger into the GTP-binding pocket...

Ngày tải lên: 11/09/2015, 16:06

... the importance of PT in the mitochondrial apoptosis, because in the absence of the hallmarks of PT, including the loss of the inner membrane potential and the rupture of the outer membrane, the ... hypoxia), and they found that the type, strength and kinetics of the target gene profiles depend on the levels of p53 in the cell, the type of in...

Ngày tải lên: 14/09/2015, 14:11

... damaging and telomeretelomerase effects and hence the mechanism of action of TQ in breast cancer cells In addition, it is of interest to investigate the effects of TQ in normal breast epithelial cells ... Black cumin seeds (left) and chemical structure of thymoquinone (right) 23 Figure 10 Growth inhibitory effects of TQ on breast cancer cells 39...

Ngày tải lên: 30/09/2015, 13:41

... Upregulation of TRPV4 protein and mRNA across the BCM model 3.1.4 Upregulation of TRPV4 in invasive human breast cancer cell lines and tissues 37 37 42 TRPV4 is a positive regulator of breast cancer metastasis ... roles and modes of actions in breast cancer metastasis remain obscure We hypothesize that TRPV4 is a positive regulator in breast canc...

Ngày tải lên: 02/10/2015, 17:15

... objectives of the study are to: Validate breast cancer cells as a model to study the dual inhibition of mTOR and telomerase Investigate rapamycin s inhibition of the mTOR pathway and telomerase in breast ... test the efficacy of mTOR kinase domain inhibitors in preclinical and clinical studies (Menon and Manning 2008) These will be discussed in det...

Ngày tải lên: 05/10/2015, 13:53

... protein-29 (ERp29) is a chaperone protein that functions in the unfolding and escort of secretory proteins Like other reticuloplasmins, ERp29 is believed to be involved in carcinogenesis In breast ... proteins, including CDC42, Par6 and aPKC, did not seem to be involved in the ERp29- induced epithelial morphogenesis These findings demonstrated a novel function and...

Ngày tải lên: 13/10/2015, 15:55