NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity

... hypoxia and reoxygenation have been reported to induce DNA damage [30–32], we examined the effects of pyruvate addition during hypoxia and after reoxygenation on DNA damage HepG2 cells were incubated ... by Singh et al [48], using alkaline electrophoresis, which allows detection of single-strand and double-strand breaks Pyruvate reduces DNA damage during...

Ngày tải lên: 18/02/2014, 16:20

... ⁄ Akt signaling was not necessary for EGFinduced protection of TMK -1 cells against apoptosis Role of AP1 in EGF-mediated cell protection A B C MAP kinase signaling provides an alternative pathway ... induced by DNA-damaging agents Oncogene 17 , 13 1 14 1 15 Geier A, Beery R, Haimsohn M, Hemi R, Malik Z & Karasik A (19 94) Epidermal growth factor, phorbol e...

Ngày tải lên: 19/02/2014, 06:20

... Scheme [24] Scheme Kinetic scheme of self-adenylation of T4 DNA ligase ể FEBS 2003 Kinetics of nick sealing by T4 DNA ligase (Eur J Biochem 270) 4321 T4 DNA ligase binds ATPMg noncovalently, ... between the steps of transadenylation and nick- sealing Abortive adenylation leads to the build-up of the AMPndsDNA pool and to the ể FEBS 2003 Kinetics...

Ngày tải lên: 21/02/2014, 00:20

... 6075 p53, p73 and HIPK2 in apoptosis N Bitomsky & T G Hofmann Fig Regulation of DNA damage- induced cell death by p53 and HIPK2 Genotoxic stress-induced DNA damage facilitates activation of the DNA ... (2009) 607 4–6 083 ª 2009 The Authors Journal compilation ª 2009 FEBS N Bitomsky & T G Hofmann p53, p73 and HIPK2 in apoptosis Fig Regulation of...

Ngày tải lên: 16/03/2014, 00:20

... its role in the DNA damage response In addition, the extreme COOH-terminal region (amino acids 734–754) of Nbs1 mediates the interaction of Nbs1 with ATM and the recruitment of ATM to sites of DNA ... MRN foci [19–21] The Mre11-binding domain of human Nbs1 has been localized to amino acids 682–693 in the COOHterminal region of the protein Deleti...

Ngày tải lên: 16/03/2014, 13:20

... Ligation of ssDNA by T4 DNA Ligase nontemplated ligation on ssDNA substrates [29,30], this property of T4 DNA ligase has, to our knowledge, not been reported Unlike T4 DNA ligase, bacterial DNA ... ligases would also result in template-independent ssDNA ligation Oligonucleotide I was incubated with either E coli DNA ligase, Taq DNA ligase, or Ampligase...

Ngày tải lên: 23/03/2014, 11:20

... pathogen inoculation was sycamore (mean of lesion 48.16 mm; P < 0.05) and the second one was beech (mean of lesion 22.07 mm) The differences among lesion extent on beech, alder and lime were distinct, ... experiment III Confirmation of water stress effect on lesion development The P cactorum isolate No P078.07 and 2-year old saplings of common beech were u...

Ngày tải lên: 07/08/2014, 10:21

... VUSS gniwollof sllec lamred dna lamredipe ni htob ,ylralullecartni 122 ortiv ni dnuof erew sDPC ,snoitidnoc latnemirepxe ruo rednU ]41,5[ noisserppusonummiotohp dna sisenegonicracotohp htob ni elor ... VUSS retfa dna erofeb htob deilppa saw taht louqE )2 giF( erusopxe VUSS )a /b( gniwollof syad dna erusopxe VUSS ot roirp syad rof deilppa saw ti nehw ,sDPC decudni-VUSS tsniaga tcetorp...

Ngày tải lên: 07/08/2014, 18:21

... sulp eniccav AND 342PV -ANDcp htiw( γ-FNIhC sulp eniccav AND ,)egnellahc dna NDO-GpC sulp eniccav AND 342PV-ANDcp htiw( NDO -GpC sulp eniccav AND ,)egnellahc dna ADD sulp eniccav AND 342PV-ANDcp ... ADD sulp eniccav AND ,)egnellahc dna eniccav AND 342PV-ANDcp htiw( enola eniccav AND ,)egnellahc htiw tub eniccav tuohtiw( lortnoc egnellahc ,)egnellahc dna noitaniccav tuo...

Ngày tải lên: 07/08/2014, 18:21

... and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo Radiation Oncology 2010 5:70 Submit your next manuscript to BioMed Central and take ... production and radiosensitizing effect in vitro of a scFv antibody against DNA-PKcs [19] This scFv antibody was originally generated from a...

Ngày tải lên: 09/08/2014, 09:20

... design DNAdirected alkylating agents by linking the alkylating pharmacophore to the DNA- affinity molecules (e.g., DNA intercalating agents, DNA minor groove binder) [7,8] In most cases, the DNA- directed ... article as: Chu et al.: Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through...

Ngày tải lên: 09/08/2014, 09:20

... (from days 32 to 66) and chronic phase (from days 66 to 158), because there was a decrease in the mean arthritis score after day 66 in wild-type mice COMP deficiency led to early onset of the disease, ... molecules of the immune system reach and bind other cartilage proteins To test whether COMP deficiency, like collagen IX deficiency, influences the antigenic/immuno...

Ngày tải lên: 09/08/2014, 13:22

... cellular signaling to regulate synaptic growth erect wing integrates cellular signaling to regulate synaptic growth (a-d) Genetic interaction of ewg with known signaling pathways in synaptic growth regulation ... Erect wing rescues viability and synaptic growth defects of elav mutants Erect wing rescues viability and synaptic growth defects of elav muta...

Ngày tải lên: 14/08/2014, 08:21

... Species 1.2 Oxidative and Nitrosative Damage in DNA 1.2.1 DNA damage Induced by Reactive Oxygen Species 1.2.2 DNA Damage Induced by Reactive Nitrogen Species 1.3 Mutagenicity of Oxidative and Nitrosative ... Nitrosative DNA Damage Products 14 17 1.4 Methods Used in the Quantitative Study of Oxidative and Nitrosative DNA Damage 1.5 Aims of this Study 18...

Ngày tải lên: 16/09/2015, 08:31

... NBS1 DEFICIENCY PROMOTES GENOME INSTABILITY BY AFFECTING DNA DAMAGE SIGNALING PATHWAY AND IMPAIRING TELOMERE INTEGRITY HOU YANYAN (Bachelor of Science, ... 84 4.1 NBS1 deficiency affects the DNA damage response 84 4.2 NBS1 deficiency compromises telomere integrity 92 IV 4.3 NBS1 deficiency promotes genome instabilities and is implicated...

Ngày tải lên: 12/10/2015, 17:35