ELUCIDATING THE ROLE OF AUTOPHAGY IN ZEBRAFISH MODELS OF LIVER CANCER

... illustrates the main structural, theoretical and incentive-related policy implications of circuit theory of finance Section I.2 discusses the special role of the financial system as the core of the circuit ... profitability is declining The internalization of information within the same institution may thus enhance intra -circuit and inter -circuit st...

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Ngày tải lên: 25/10/2013, 05:20

... anti-IL-1 therapy AntiIL-17 cytokine therapy might be an interesting new antirheumatic approach that could contribute to the prevention of joint destruction as an adjunct to anti-TNF and anti-IL-1 therapy ... together regulate interleukin-17- induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-...

Ngày tải lên: 09/08/2014, 06:22

... complex process involving several actors, including signaling pathways like the Notch pathway Further work is required to understand the complexity of Notch signaling during cartilage pathology and ... recently reported expression of Notch family members in adult and even OA cartilage raised the issue of the involvement of this pathway in the physiopathol...

Ngày tải lên: 12/08/2014, 15:22

... Without her, I am nothing Funding Source: RO1HL077328 (IP) iii Matthew Jose Justice THE ROLE OF ACID SPHINGOMYELINASE IN AUTOPHAGY Autophagy is a conserved cellular process that involves sequestration ... December 2013: MATTHEW JOSE JUSTICE Master of Science – Biochemistry & Molecular Biology Indiana University, Indianapolis, Indiana Project 1: Role of acid sphingomyeli...

Ngày tải lên: 24/08/2014, 09:45

... unwavering support of my goals iv ABSTRACT Sara M McNeil ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU8 0 CTERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU DNA double strand breaks ... than that of the 16 kDa Ku8 0CTR band and the band intensity generated from Ku7 0 and Ku8 0 C antibodies, indicating a small per...

Ngày tải lên: 24/08/2014, 11:02

... et al., 20 01; Suzuki and Ohsumi, 20 07) Atg19 is the cargo receptor protein involved in the Cvt pathway (Scott et al., 20 01) Atg20 and Atg24 bind PtdIns(3)P and belong to the sorting nexin family ... complementation, and RFP and GFP tagging are given in Table (specifying the backbone vector chosen and the corresponding fungal selection marker) 2. 2 .2 DNA te...

Ngày tải lên: 11/09/2015, 10:01

... 297 298 30 0 30 2 30 3 30 4 30 6 30 7 30 7 30 8 Abstract Autophagy is a bulk degradative process responsible for the turnover of membranes, organelles, and proteins in eukaryotic cells Genetic and molecular ... regulated in the atg8Δ mutant and investigate the role of autophagy and nutrient utilization during conidiation and in planta growth in Magnap...

Ngày tải lên: 11/09/2015, 10:01

... selective, depending on the specific biological circumstance and/ or the specific inducer involved Autophagy was first identified and characterized in yeast and in animal cells In recent years, autophagy ... Generation and characterization of an atg20∆ mutant in Magnaporthe 90 4.2.2 Subcellular localization of Atg20 .90 4.2.3 Investigation of non-selective autoph...

Ngày tải lên: 11/09/2015, 10:01

... region of < /b> SHIP-1 binds to Dok-< /b> 3 < /b> at domain B and D; the < /b> SH2 domain of < /b> Grb2 binds to 39< /b> Dok-< /b> 3 < /b> at domain D; while the < /b> region responsible for binding of < /b> Abl to Dok-< /b> 3 < /b> at B is still unknown 1.4.5 .3 < /b> Dok-< /b> 4, ... SC -37< /b> 1 SC- 728 SC- 738< /b> 3 39< /b> 41 Goat Goat Rabbit Rabbit Rabbit Rabbit R...

Ngày tải lên: 14/09/2015, 09:08

... An inhibitory adaptor regulating B cell receptor signaling 3.< /b> 1 Introduction 75 3.< /b> 2 Generation of < /b> Dok-< /b> 3 < /b> deficient mice 76 3.< /b> 3 Studying the < /b> role < /b> of < /b> Dok-< /b> 3 < /b> in < /b> B cell development 81 3.< /b> 3.1 Dok-< /b> 3 < /b> is ... FcγRIIB signaling 3.< /b> 7.2 Role < /b> of < /b> Dok-< /b> 3 < /b> in <...

Ngày tải lên: 14/09/2015, 10:44

... THE ROLE OF NITRIC OXIDE AND OTHER GASEOUS MEDIATORS IN CARDIOVASCULAR DISEASE MODELS: EMPHASIS ON SEPTIC SHOCK FARHANA ANUAR B.Sc.(Hons.), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF ... pathogenesis of tissue damage incurred by the host in the course of severe sepsis and septic shock 2.3 Evidence for the involvement of NO in...

Ngày tải lên: 14/09/2015, 14:16

... THE ROLE OF CYCLOPS/ NODAL SIGNALING IN ZEBRAFISH EARLY EMBRYOGENESIS TIAN JING (M.Sc.) Wuhan Institute of Virology Chinese Academy of Science A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF ... representation of the TGFβ signaling from cell membrane β to the nucleus The TGFβ ligand initiates signaling by binding to and bringing together type I and type...

Ngày tải lên: 15/09/2015, 17:09

... 28 2. 1 Fish Spawning and Maintenance 28 2. 2 Molecular Biology Techniques 28 2. 2.1 RT-PCR Molecular Cloning 28 2. 2 .2 Polymerase Chain Reaction (PCR) 29 2. 2.3 Agarose Gel Electrophoresis 29 2. 2.4 ... prior finding of possibly interacting proteins of BNIP- 2 led to the formation of research questions: Does the physical interaction of BNIP- 2 with these prote...

Ngày tải lên: 05/10/2015, 19:05

... transgenic line Establishing the role of autophagy in liver cancer 4.1 Preliminary data implicating autophagy inhibition in liver cancer 4.2 Establishing double transgenic lines with liver- specific ... as a model organism in the study of human diseases including cancers, we aim to investigate the role of autophagy in liver cancer using our establish...

Ngày tải lên: 12/10/2015, 17:35