the role of micrornas in the management of liver cancer

... transgenic line Establishing the role of autophagy in liver cancer 4.1 Preliminary data implicating autophagy inhibition in liver cancer 4.2 Establishing double transgenic lines with liver- specific ... present in a gene-ofinterest Progeny identified to carry the desired mutations are then propagated to maintain the line to study the function of the gene -of- interest Furthermore, fluorescent proteins ... transgenic line in liver cancer study as well as other studies involving liver development or liver diseases in the zebrafish Similar methodology used in the generation of the EGFP-LC3 transgenic line...

Ngày tải lên: 12/10/2015, 17:35

... liver cells and in primary rodent HCC cancer cells induced by chemical carcinogens Since the HCC cancer cells and fetal liver cells used in our study originated from the same inbred rat strain, ... heterogeneity of cancer due to aberrant differentiation According to the hierarchical model of cancer, the origin of the cancer stem cells may be long-lived somatic stem cells Therefore, markers of “normal” ... cells are believed to be the tumor-initiating cells of HCC, we speculate that screening of circulating miRNAs in the serum could help to predict the presence of liver cancer stem cells and that...

Ngày tải lên: 10/08/2014, 10:20

... raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of a concern for people in the behavioural theories as being ... anything towards raising the profile of women in management, as the theory was constructed as a male model at a time when women were not visible in paid employment One of the off shoots of the ... valued At the time these theories were achieving prominence, the numbers of women were also beginning to rise dramatically in management roles One significant finding that has arisen from the transactional...

Ngày tải lên: 08/10/2013, 15:56

... Figure 19 in the timing and intensity of rainfall, or the period of time without rain, as well as affecting the quality of water in rivers and lakes through changes in the timing and volume of peak ... events from the origin of the wastewater to the consumption of the produce (e.g the farm-to-fork approach of the HAPPC method in food safety); • the design of a combination of health risk management ... Hoepner,2008) There is scope to improve the sustainability of the desalination process The process results in the discharge of a concentrated brine into the receiving waters Temperature and salinity...

Ngày tải lên: 17/02/2014, 10:20

... to the natural protectorate law and the decision of the Prime Minister regulating to activities inside the protectorates in addition to the inefficiency of the biological treatment project of ... microbiological properties of groundwater in Saint Katherine, South Sinai, Egypt and exploring the diversity, occurrence and distribution of fungal taxa in groundwater in South Sainai, samples of groundwater ... Azeem was one of a few Media reported the progress in increasing interest.[19],[20].to investigate the amount and seriousness of pollution caused by factories dumping their waste in the Egyptian...

Ngày tải lên: 18/02/2014, 04:20

... benefits of its use, including across domains to deliver joined-up services over the Internet The scope of the Primer is limited to the management of the digital identities of individuals, or natural ... explains some of the key concepts and outlines some of the basic IdM processes The range of conceptions of identity is very broad The examination of the following concepts is for the purposes of ... to take into account in the assessment of the security risks to − and privacy impact on − the delivery of online services, and in determining appropriate levels of security  In the case of sensitive...

Ngày tải lên: 23/03/2014, 23:21

... evaluate the return potential of investment opportunities (the ex-ante or valuation role of accounting information) Second, accounting information allows capital providers to monitor the use of their ... words inclusive of all exhibits and references The deadline for the submission is the last day of the final exam period PhD Program in Economics and Management Advanced Financial Accounting Program ... reduce the level of information asymmetries existing among market participants Looking at contemporary empirical financial accounting research, the course introduces students to the main theories...

Ngày tải lên: 29/03/2014, 14:20

... differing interests in the project In allocating resources they will have an interest in the efficient use of the resources during development The project team will be responsible for the planning ... achieving work are stressed and become paramount in people's thinking The scope of interest here will be the completion of work and delivery of the project Any rewards for the 83 The role of project ... control of the use of these resources, consequently the parent organisation will be interested in the success of the project management process The team will be accountable for their use of these...

Ngày tải lên: 29/03/2014, 23:20

... Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without...

Ngày tải lên: 03/06/2014, 02:17

... upper gastrointestinal surgeons with training in these techniques may have an increasing role in the diagnosis of lymphomas In cases of intrathoracic lympahadopathy, newer minimally-invasive techniques ... baseline against which the effects of chemotherapy may be judged The aim of this study was to examine whether the 21st century surgeon still has a role to play in the diagnosis and management of ... University in the late 1960s which showed that the performance of a staging laparotomy altered the stage of disease in 42% of cases, up regulating in 28% and down regulating in 14% of cases [2] The...

Ngày tải lên: 09/08/2014, 07:21

... an increasingly important role in clinical management of CAP in the future Search strategy A Medline and PubMed search of relevant medical literature in the English language published in the ... copeptin increased with increasing severity of the PSI and was an independent predictor of outcome, in contrast to other clinical symptoms and findings [49] In a study of 302 patients admitted to the ... prognostic indicator [39] Further study of this remarkable plasma protein is warranted in the future to determine its practical clinical value in the management of severe CAP Other biomarkers are continuously...

Ngày tải lên: 13/08/2014, 19:20

... symptoms Whether this may truly prove a useful diagnostic biomarker among the increasing number of alternatives investigated [17-19], or merely be yet another blind alley in the surge for the correct ... Søreide: The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley? Scandinavian Journal of Trauma, ... inflammation The mechanism of inflammation and damage is binding to toll-like receptor (TLR4), which mediates HMGB1-dependent activation of macrophage cytokine release This positions HMGB1 at the intersection...

Ngày tải lên: 13/08/2014, 23:20

... information sharing change? The study shows that the value of information sharing increases as the number of supply chain members participating in information sharing increases This corroborates the positive ... that the analytical study considers only the benefits of sharing information, not the costs of sharing information Since many costs of information sharing are intangible, it is hard for the analytical ... such as purchasing and delivery The concept of supply chain management extends the operations within a single business unit to the entire supply chain A supply chain consists of a set of processes...

Ngày tải lên: 02/11/2014, 00:47

... combinations of actions; • Identifying the constraints of these moves and the ways their elements can be recombined for economizing combinations Given the richness of data and understanding of ... gaps in our current understanding The review explores the resource-based view (RBV) of the firm, building a conceptual understanding of the role of resources, capabilities and routines in the ... interviews were conducted with the aim of understanding rather than explaining the activities and changes in the context of case organizations In the majority of interviews at AH, initial questions were...

Ngày tải lên: 10/09/2015, 15:50

... differentiation in vivo Chapter challenges the dogma that animal microRNAs only target the 3’UTRs of genes This will be investigated in the context of microRNAs targeting the coding regions of transcription ... layer for indefinite self-renewal in culture 1.1.3 Maintaining Pluripotency: LIF, BMP & Wnt Signalling One of the major breakthroughs in ESC maintenance was reported in 1988, when leukemia inhibitory ... noncoding RNAs similar to the siRNAs involved in RNA silencing, originate from stem-loop precursors in the genome They have been shown to play important roles in diverse processes including apoptosis,...

Ngày tải lên: 12/09/2015, 08:16

... Governance in the UK found, but the monitoring role of the board of directors on income-increasing earnings management is more pronounced where audit committee exists These interesting findings suggest ... of outside directors on the board and the level of earnings management Besides the proportion of outside directors on the board, the separation of the roles of the chairman of the board and the ... serving as the chair of the board Thus, the second hypothesis is proposed: Hypothesis 2: The combination of the roles of CEO and the chairman of the board in one person is positively related to the...

Ngày tải lên: 05/10/2015, 19:01

... proteins that play an important role in maintaining protein homeostasis in the cell by aiding the process of proper folding of proteins and thereby preventing the accumulation of misfolded proteins ... 2009) whereas the C-terminal domain has ubiquitin interacting motifs (UIMs) which define the specificity of the Josephin domain to cleave ubiquitin chains having linkages at Lys63 (Winborn et al, ... mRNA (b) The initial exons code for the Josephin domain in the ATXN3 protein, the rest of the exons code for the C-terminal domain with the polyQ chain encoded by the 10th exon (c) Introduction...

Ngày tải lên: 26/11/2015, 10:00

... practices of establishing legal position and ensuring the principle of independence ofSAV activity 4.1.1.4 Enhancing the role of the SAV in public debt management on the basis of raising relationship ... evaluating the role of state audit in public debt management At the same time, the thesis clarified the contents of the SAV role in public debt management as: (1) the confirmation of information ... ENHANCE THE ROLES OF STATE AUDIT IN PUBLIC DEBT MANAGEMENT IN VIETNAM Secondly, the role of SAV in public debt management must be overall determinative in the relationship of the state budget finance...

Ngày tải lên: 02/05/2016, 23:22

... profitability is declining The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing The ... Creating a stronger investor base amounts to strengthening the circuit by completing the financial market structure of the economy, thus eliminating discontinuities in the transmission of information ... placing money with investment financial institutions in the capital market, and hold the remaining share in noninterest bearing, short-term bank deposits (eq 7) The share of savings going to the...

Ngày tải lên: 24/10/2012, 09:33

... in the development of the oxidative stress (68) If our findings are proven by further studies involving a larger number of patients, ultra-low microcurrent therapy might change the concept of management ... pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy Obesity (Silver Spring) 2006;14 (Suppl 1): 34S–40S 31 Boden G Role of fatty acids in the pathogenesis of insulin resistance ... ZW, Karin M, Perret P, Shoelson SE, Shulman GI: Prevention of fat-induced insulin resistance by salicylate J Clin Invest 2001; 108:437–446 52 Evans L Antioxidants: they have a role in the management...

Ngày tải lên: 26/10/2012, 09:39