UNDERSTANDING THE MOLECULAR MECHANISM OF CENTRINS IN TRYPANOSOMA BRUCEI

... with the sequences of 1CEV and 1RLA and pasted into the structural alignment The alignment was then corrected by hand Since the sequences of the two arginases and agmatinase greately differ in the ... that the environment of tryptophan residues is essentially conserved in the mutant enzyme On the other hand, the absence of major differences in the CD...

Ngày tải lên: 21/02/2014, 01:21

... mutations at these positions in Sendai should promote instability of the surface region As the C region of Sendai also would play an important role in restraining the conformational change of the surface ... temperature indicates the stability of the structure of the protein The difference of the increments between the inactive temperature and...

Ngày tải lên: 21/02/2014, 03:20

... b-strands instead of eight, with the C and D strands and the intervening loop forming a large loop, exposing some hydrophobic residues in this region that are normally buried on the inside of the ... the protein [98] Dislocation of the C and D strands from their native edge region may result in the formation of a new interface involving A and B strands which...

Ngày tải lên: 07/03/2014, 10:20

... using surface plasmon resonance analysis to determine the role of residue 71 in collagen binding The elucidation of the mechanism of structural protein substrate recognition in serine proteases should ... compilation ª 2009 FEBS 5643 Substrate recognition mechanism of Streptomyces trypsin into the NdeI–HindIII gap of pTONA5a to construct the expressio...

Ngày tải lên: 16/03/2014, 00:20

... Metal- assisted growth of SiNWs A basic aspect of the VLS mechanism is the metal particle acting as a catalyst for the anisotropic growth of SiNW with a crystalline structure A catalyst particle ... substrate (Fig 2B a) , a liquid metal Si alloy will be formed With more and more Si atoms added, the Si content in the If the growth with a...

Ngày tải lên: 16/03/2014, 15:09

... required Inferential work le relatively transparent The event of John's entering the o n c e results in the state of his being in the ofrice: this le part of the lexical meaning of enter The temporal ... their mother to fix the tail v-~hveof the windmilL b In the great expanse of the prairie where they lived, the high tower of the windmill was the...

Ngày tải lên: 18/03/2014, 02:20

... as important catalytic residues, indicating a role in binding the nucleotide into the active site [15,16] The crystal structure of CNS from Neisseria meningitidis crystallized in the presence of ... stereo-view of the residues of interest (blue) in the active site of the CNS from Neisseria meningitidis containing CDP (yellow) (PDB 1EYR) [12] su...

Ngày tải lên: 22/03/2014, 21:21

... Lgt4 Results In order to investigate the function of the glycosyltransferase enzymes involved in the biosynthesis of LOS of M catarrhalis, and to gain some insights into the mechanism of serotype ... irradiating each of the anomeric signals in turn to obtain the H chemicals shifts of the corresponding remaining ring protons Again, assignment of the Kdo...

Ngày tải lên: 30/03/2014, 08:20

... the lack of a satiety signalling, whereas no change in food intake was detected in the B [a] P-treated animals In addition, the absolute values of leptin in control and B [a] P-treated animals were ... Results are shown as the average weight gain every days ± SEM rine-induced lipolysis Chronic (15 day) B [a] P exposure caused a significant weight gain and increa...

Ngày tải lên: 30/03/2014, 11:20

... spontaneously produced in organ cultures of synovial tissues derived from RA patients Addition of anti-inflammatory cytokines IL-4 and IL-13 completely inhibited the production of IL-17 in synovial ... by activated T cells was completely inhibited by adding OPG 284 Using an ELISA system, we measured the level of a soluble form of RANKL in the synovial fluids Concentrations of...

Ngày tải lên: 09/08/2014, 06:22

... dataset they gener­ ated to compare the gene-expression profile of human embryos with that of human embryonic stem cells (hESCs) maintained in culture They found that approxi­ mately 20% of the genes ... that the early expression of PAX6 in humans (similar to their previous results with rhesus monkey embryonic stem cells), may have been a step in the evolution of...

Ngày tải lên: 09/08/2014, 20:22

... being there for me You inspire and motivate me every day of my life Thank you 
 iv
 ABSTRACT Brandy Lee Akin INVESTIGATING THE MOLECULAR MECHANISM OF PHOSPHOLAMBAN REGULATION OF THE Ca2+-PUMP OF CARDIAC ... back into the lumen of the SR by the Ca2+ pump, SERCA2a, making Ca2+ available for the next contraction (1) Therefore, the rate of Ca2+ transport by S...

Ngày tải lên: 24/08/2014, 11:06

... Disclaimer Title of Thesis/Dissertation: The Molecular Mechanism of Break Induced Replication For the degree of Master of Science Choose your degree I certify that in the preparation of this thesis, I ... The Molecular Mechanism of   Break Induced Replication  Major  Professor:  Anna  Malkova     DNA  double  strand break  (DSB)  is  one of the  most  thre...

Ngày tải lên: 24/08/2014, 13:24

... molecular mechanisms of TbCentrin2 and TbCentrin4 in Trypanosoma brucei viii Centrins are EF-hand containing proteins that bind Ca2+ They are regulatory proteins functioning through specific binding ... database screening for T brucei proteins containing centrin binding motif initially characterized in Sfi1p have been used Centrins are proteins functioning through interactio...

Ngày tải lên: 12/10/2015, 17:35

... nodes behind the breastbone Or Inflammatory breast cancer is a rare type of breast cancer The breast looks red and swollen because cancer cells block the lymph vessels in the skin of the breast ... dissertation, the author attempt to investigate how ERp29 may regulate another effector of PERK, Nrf2 in breast cancer cell lines The levels of eIFα...

Ngày tải lên: 12/10/2015, 17:35