5 SUBSTITUTED BENZIMIDAZOLE DERIAVATIVES AS ANTI STROKE AGENTS
Báo cáo khoa học: Natural polyphenols as proteasome modulators and their role as anti-cancer compounds doc
... decaffeinated black tea II I–II I I Phase I–II Phase I–II Phase II Phase Phase Phase Phase Tea polyphenols and theaflavins III III I–II II II II II II II Phase II Phase II Phase II FEBS Journal 275 (2008) ... proteins, activation of caspase and caspase 7, and cleavage of poly(ADP-ribose) polymerase The inhibition of proteasome activity by these fruit or vegetables may contribute to...
báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
... mice Effect of anti-inflammatory drugs on glia activation and vascular amyloid deposition Ibuprofen or pioglitazone treatments were started at months of age and continued for months Two reasons ... anti-inflammatory drugs started at months of age, soon after weaning, and was carried out for months Ibuprofen was purchased from Sigma, and pioglitazone, manufactured by Takeda Pharm...
Báo cáo hóa học: " Purification and characterization of novel fibrinolytic proteases as potential antithrombotic agents from earthworm Perionyx excavatus" pot
... doi:10.1186/2191-0855-1-26 Cite this article as: Phan et al.: Purification and characterization of novel fibrinolytic proteases as potential antithrombotic agents from earthworm Perionyx excavatus AMB Express 2011 1:26 ... such as KM, Vmax, and Kcat Applicability of P excavatus proteases Serine proteases The inhibitory effect of PMSF towards all fracti...
báo cáo khoa học: "Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents" ppt
... p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor ... Targeting histone deacetylases in neuroblastoma Curr Pharm Des 2009, 15:436-447 56 Martinez-Iglesias O, Ruiz-Llorente L, Sanchez-Martinez R, Garcia L, Zambrano A, Aranda A: Histone...
Báo cáo y học: "Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein" pptx
... [http://www.fimdefelice.org/archives/arc.researchact html] doi:10.1186/1476-9255-7-49 Cite this article as: Mathison et al.: Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical ... was measured histologically, by determination of plasma amylase and lipase activity, and by immunoassays • In vitro and ex vivo studies on...
Báo cáo khoa học: "Plants as De-Worming Agents of Livestock in the Nordic Countries: Historical Perspective, Popular Beliefs and Prospects for the Future" docx
... and parasites There is an inextricable association between plants and parasites of livestock Pastures provide the link between the free-living and the parasitic phases of helminth parasites for ... tannins forming non-biodegradable complexes with protein in the rumen, which dissociate at low pH in the abomasum to release more protein for metabolism in the sma...
Synthesis and biological evaluation of 2 substituted benzimidazole derivatives
... time in second (Mean ± SEM) 0h 2h 3h 4h 1.56 ± 0.16 2. 16 ± 0.16 2. 0 ± 0 .25 2. 16 ± 0.16 2. 0 ± 0 .25 2. 0 ± 0 .25 1.61 ± 0.30 2. 16 ± 0.30 2. 0 ± 0 .25 2. 16 ± 0.16 2. 0 ± 0 .25 2. 16 ± 0.16 Control Std 3a 3b ... 14.38; found C 57 .29 , H 3.65, N 14.45 Synthesis and biological evaluation of 2- substituted benzimidazole derivatives 2. 2 .2. 2 (1H-Benoimidazol -2-...
Synthesis and biological evaluation of isoindigo derivatives as anti proliferative agents
... functionalized isoindigos as antiproliferative agents, the aim of this thesis was to investigate medicinal chemistry approaches towards the design and synthesis of functionalized isoindigos with ... of isoindigos without compromising biological activity 1.5 Biological properties of functionalized isoindigos 1.5.1 Mode of action of meisoindigo Meisoindigo is the most wid...
Derivatives of pyrazolo1,5 a1,3,5triazines as enzyme inhibitors with potential therapeutic value
... migration of endothelial cells.64 Thymidine phosphorylase promotes tumor metastasis It has been found that high TP expression was associated with metastasis, and TP was able to increase the metastatic ... derivatives as inhibitors of thymidine phosphorylase 23 ii 1.2.3.2 Purine derivatives as inhibitors of thymidine phosphorylase 29 1.2.3.3 Thymidine phosphorylase inhibit...
A study of alginate matrices as anti microbial wound dressing
... important characteristics of these anti- microbial agents and their associated products that are available in Singapore are summarised in Table Topical anti- microbial agents confer several therapeutic ... Properties of common topical anti- microbial agents and their associated products used for wound management Class Anti- microbial agent Products (Manufacturer) Mechanism...
Isolation and identification of components from ixeris sonchifolia hance as potential anti stroke agents
... Evaluation of antioxidant activities of fractions to isolated from Ixeris sonchifolia Hance extract 44 2.4 Discussion and conclusions Chapter Isolation and characterization of components from ethyl ... Possible anti- coagulation activities of fractions to isolated from Ixeris sonchifolia Hance extract 42 2.3.2 Effects of fractions to isolated from Ixeri...
5 SUBSTITUTED BENZIMIDAZOLE DERIAVATIVES AS ANTI STROKE AGENTS
... http://www.strokecenter.org/trials/interventions?tid=17 Cerebrovasc Dis 2000; 10(6): 431-6 Stroke 2000; 31(11): 254 3 -51 Stroke 2000; 31(2): 347- 354 JAMA 2001; 286(21): 2673-2682 10 Stroke 19 95; 26(2): 254 - 258 12 Dizocilpine5 Remacemide 12 ... 363(9407): 439- 45 Stroke 1999; 30(9): 1796-1801 13 JAMA 2001; 2 85( 13):1719-1728 14 Stroke 1999; 30(3) :50 8 -51 3 15 Ann N Y Acad...
Isothiocyanate derivatives as anti cancer agents
... initiation or the promotion-progression phases Cancer chemopreventive agents can be classified as antimutagens/carcinogen blocking agents, antiproliferatives, or antioxidants (Table 1.1) Numerous purified ... has isothiocyanate agent, then test whether they can prohibit or kill MDA-MB-231/MCF-7 breast cancer cell The classification of isothiocyanates and the mechanism about why the...