k channel openers as new anti arrhythmic agents

... importance of voltage-gated K+ channels (KV), calciumactivated K+ channels (KCa), and ATP-sensitive K+ channels (KATP) in transepithelial ion transport has been implicated [18-22] KV channels constitute ... (i.e., KVLQT1-KV7.1, KNCQ, and KCNQ channels) So far, KCNQ and but not have been identified in H441 cells by a very recent publication [23] KCa channels, until recently known as K Ca3.1 and BKCa, ... apical and basolateral conductance by K+ channel openers? If the K+ channel openers restore the depressed ENaC and Na+ /K+ -ATPase by stimulating K+ influx which facilitates Na+ /K+ -ATPase in intact...

Ngày tải lên: 12/08/2014, 11:22

... Unlike paclitaxel and irinotecan which were derived from natural products, imatinib was developed by rational drug design Imatinib inhibits the kinase BCR-ABL as well as the KIT tyrosine kinase ... such as apoptosis stimulating fragment (Fas) and other members of the tumornecrosis factor (TNF) receptor family These receptors activate caspase-8 and subsequently caspase-3, the major caspases ... The released cytochrome c interacts with apoptotic protease activating factor (Apaf-1) and activates caspase-9 which in turn proteolytically activates downstream caspase3.5 Activated caspase-3...

Ngày tải lên: 10/09/2015, 15:49

... streptokinase (Lopez-Saura, 2003), urokinase 10 (Shrivastava et al., 2007), reteplase (Khatri et al., 2008), tenecteplase (Burkart et al., 2003) and desmoteplase (Hacke et al., 2009; Liebeskind, ... heat-shock proteins ICA internal carotid artery IL-1 interleukin-1 IL-10 interleukin-10 IL-6 interleukin-6 iNOS inducible NOS IR infrared spectroscopy JNK c-jun-N-terminal kinase Keap1 Kelch-like ECH-associated ... of anti- stroke agents in preclinical studies and in clinical applications Objective Mechanism Anti- stroke agents in preclinical studies or in clinical use Thrombolysis alteplase (rtPA), urokinase,...

Ngày tải lên: 11/09/2015, 10:06

... histochemistry as well as recovery of locomotor function • Pancreatitis induced in mice by intravenous injection of caerulein was measured histologically, by determination of plasma amylase and lipase activity, ... decreased to baseline values over hours, but was followed by a secondary increase in SRL after hours post challenge Inhaled feG at a dose of 30 mg/sheep reduced early as well as late increases ... SRL, whereas treatment with feG intravenously (1 mg/kg) or orally (2 mg/kg) inhibited only late phase bronchoconstriction (mean ± sem, n = to 8) Adapted from [51] increase in vascular leak of a...

Ngày tải lên: 11/08/2014, 03:20

... egasod a ta deretsinimda saw hcihw )aeroK ,naskuD( dica cirtic %3.41 ni dednepsus erew LA2050 -PV dna 2050-PV ,yduts laro eht roF w.b gk/lm 5/gm 02 fo egasod a ta niev liat eht detcejni dna )ASU ... S niaJ ,KN niaJ ,KA yrawiT ,A laskuK 075-665 ,38 ,4991 icS mrahP J gurd elbulos ylroop a fo setatipicerpoc ciretne fo noitprosba laro devorpmI T imuyaM oviv ni ,ortiv ni ,Y awagO ,K noK ,Y arahihsI ... = n( DS ± naem sa detroper erew sretemarap citenikocamrahp detamitse eht dna snoitartnecnoc gurd amsalP )t · ak-pxe-t · lek-pxe( · )lek-ak(/dV/ak · D = )t(C saw noitartsinimda laro rof alumrof...

Ngày tải lên: 07/08/2014, 23:22

... 64:1079-1090 51 Balakin KV, Ivanenkov YA, Kiselyov AS, Tkachenko SE: Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective Anticancer Agents Med ... 10:395-398 57 Marks PA, Dokmanovic M: Histone deacetylase inhibitors: discovery and development as anticancer agents Expert Opin Investig Drugs 2005, 14:1497-1511 58 Glaser KB, Li J, Pease LJ, Staver ... deacetylase inhibitors Curr Med Chem 2003, 10:2351-2358 25 Kouraklis G, Theocharis S: Histone deacetylase inhibitors and anticancer therapy Curr Med Chem Anticancer Agents 2002, 2:477-484 26 Walkinshaw...

Ngày tải lên: 10/08/2014, 22:20

... kinase activity was monitored in a fluorescence resonance energy transfer (FRET)-based assay, only weak inhibitory activity was found for meisoindigo (IC50 CDK2/cyclin A 89 µM,).32 The contrasting ... pharmacy who has given me valuable advice It is also my pleasure to thank research assistants Ms Tee Hui Wern and Ms Audrey Chan who has assisted significantly in my earlier work Acknowledgements ... structure-based design, based on the assumption that CDK2 is the intended target This aspect will be confirmed early in the study by determining the in vitro CDK inhibitory assays and anti- proliferative...

Ngày tải lên: 10/09/2015, 08:38

... binding site, as well as a hydrophobic pocket pivotal in conferring sensitivity to phenylethanolamines such as ifenprodil (Karakas et al., 2009) 24    Since the discovery that NMDARs exist as tetrameric ... incidence of stroke in many developed countries, largely due to improved management of stroke risk factors such as hypertension and smoking (WHO, 2011) Stroke, nevertheless, remains as a health issue ... (Hatcher et al., 2011) Nevertheless, more work has to be done, as trials of new perfusion enhancing drugs such as abciximab, ancrod and prourokinase yielded disappointing results (Green et al.,...

Ngày tải lên: 12/10/2015, 17:35

... accomplished by blockade of the initiation or the promotion-progression phases Cancer chemopreventive agents can be classified as antimutagens/carcinogen blocking agents, antiproliferatives, or antioxidants ... of caspase and MAPK activation Gynecologic Oncology 103:261–270, 2006 Y R Chen, W.F Wang, A N T Kong, T H Tan, Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic ... the cells was selected as the background spectrum Based on Fig 2.1.6 and compare to that of Fig 2.1.2, two new peaks at 2065 cm-1 and 2156 cm-1 can be clearly seen One of the two peaks corresponds...

Ngày tải lên: 08/11/2015, 17:15

... becomes ∞ xk = h0 Ak + An hk−n + k (31.8) n=0 desired symbol n =k intersymbol interference 31.3 Channel Equalization Filtering 31.3.1 Matrix Formulation of the Equalization Problem The task of finding ... to the block-processing required References [1] Proakis, J., Digital Communications, 2nd ed., McGraw-Hill, New York, 1989 [2] Hatzinakos, D and Nikias, C., Estimation of multipath channel response ... systems was advanced by Proakis [1] and has found subsequent use throughout the communications literature [2, 3] It has been shown that a bandpass transmitted pulse train has an equivalent low pass...

Ngày tải lên: 25/12/2013, 06:16

... Esposito et al Alizarines as new dual HIV-1 RT inhibitors A E VAL106A PHE227A VAL108A Asp110 O K4 9 Asp110 O LEU234A Asp186 K4 9 VAL108A Asp186 O O O Asp185 O NNRTIbp Asp185 TYR318A TRP229A Trp229 ... substrate the RNase H activity was measured as described [20,39] The RDDP activity of HIV-1 RT was measured as described previously [40] Kinetic studies Analysis of the kinetics of inhibition was performed ... LEU100A Cys181 I VAL108A Asp110 PHE227A Asp186 Asp185 O O K1 26 O O O TYR188A Tyr181 O LEU234A VAL106A LEU100A Trp229 TYR318A Asn103 Fig K- 49 and KNA-53 (in sticks) best docked pose Compound interactions...

Ngày tải lên: 22/03/2014, 16:20

... nghiên cứu này, khẳng định k t luận Kelley xác, đồng thời nhận thấy HGH có tác dụng khác: - Tăng sản sinh kháng thể - Tăng sản sinh lymphô bào T IL - - Tăng hoạt tính tế bào NK - K ch thích đại ... tuổi 60 khó tìm đợc tuyến teo lại nhỏ Tuyến ức teo k o theo khả miễn dịch yếu Keith Kelley (Đại học Illinois) chứng minh tiêm HGH cho súc vật thí nghiệm già, tuyến ức lớn lên Các nhà khoa học ... vọng Tài liệu tham khảo chính: Klatz, R.; Goldman, R (2003): The New anti - aging Revolution; Basic Health Publications, Inc; North Bergen, N J 07047; Edition Rudman, D (1990): New Engl J Med.;...

Ngày tải lên: 02/04/2014, 22:21

... Fujimoto Y, Yamane K, Ikeda R, Nishio R, Terabayashi K, Ishii K, Gonda K, Matsumi Y, Ashla AA, Okamoto H, Takubo K, Tomita A, Hoshikawa Y, Kurimasa A, Itamochi H, Harada T, Terakawa N and Page 12 ... McNamara K, Xia H, Glatt KA, Thomas RK, Sasaki H, Horner JW, Eck M, Mitchell A, Sun Y, Al-Hashem R, Bronson RT, Rabindran SK, Discafani CM, Maher E, Shapiro GI, Meyerson M and Wong KK: Epidermal ... Jeremias I and Debatin KM: Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells Oncogene 2004, 23:7611–20 Rzeski W, Stepulak A, Szymañski M, Sifringer M, Kaczor J, Wejksza K, ...

Ngày tải lên: 18/06/2014, 15:20

... hematopoietic marker CD14 and various vascular markers such as Tie2 (Tie2+ Monocytes), VE-Cadherin, and VEGFR2 have been reported to take part in both ischemia-associated and tumor-associated angiogenesis ... experiments, a second vascular marker CD146 (P1H12-eBiosciences), was used in conjunction with CD45 and VE-Cadherin to increase purity Tie2 expression was confirmed using biotin -anti- humanTie2 (Abcam ... San Diego, CA) was incubated with biotin labeled anti- CD52 antibodies in a 1.5:1 molar concentration μg/ml anti- CD52-saporin conjugate was then incubated with isolated ascites-associated cells...

Ngày tải lên: 18/06/2014, 15:20

... work increase was augmented by DAP The initial increase was followed by progressive declines in work for both untreated and DAP-treated muscle Nonetheless, work of DAP-treated muscle was significantly ... effects of K+ channel blockade in aged diaphragm Am J Respir Crit Care Med 1998, 158:820-826 van Lunteren E, Moyer M, Dick TE: Modulation of diaphragm action potentials by K+ channel blockers Respir ... and K+ channel blockade to augment skeletal muscle force IEEE Trans Neural Syst Rehabil Eng 2004, 12:288-294 van Lunteren E, Pollarine J, Moyer M: Inotropic effects of the K+ channel blocker...

Ngày tải lên: 19/06/2014, 08:20

... 2000, 156:139-150 Kumar-Singh S, Cras P, Wang R, Kros JM, van Swieten J, Lubke U, Ceuterick C, Serneels S, Vennekens K, Timmermans JP, Van Marck E, Martin JJ, van Duijn CM, Van Broeckhoven C: Dense-core ... expression was increased in TGF-β1 animals mostly in astrocytes in the dentate gyrus (DG) and in perivascular astrocytes at the hippocampal fissure (HiF) The astrocytosis was decreased by pioglitazone ... Brooker MJ, Mucke L: Astroglial overproduction of TGF-beta enhances inflammatory central nervous system disease in transgenic mice J Neuroimmunol 1997, 77:45-50 Munch G, Gasic-Milenkovic J, Dukic-Stefanovic...

Ngày tải lên: 19/06/2014, 22:20

... Shepend DET, Leahy JC, Mathias KJ, Wilkinson SJ, Hukins DW: Spinous process strength Spine 2000, 25:319-323 Fischgrund JS, Markay M, Herkowitz HN, Brower R, Montgomery DM, Kurz LT: Degenerative lumbar ... In Spinal Reconstruction Clinical examples of applied basic science, biomechanics and engineering Edited by: Kai-Uwe Lewandrowski New York London; Informa; 2007:81-90 Wang JC, Spencer D, Robinson ... cranial and caudal hooks while holding the hooks with a hook holder (Figure 5C) The hooks are tightened temporarily while compression is maintained between the cranial and caudal hooks (Figure 5D) It...

Ngày tải lên: 20/06/2014, 01:20

... UM-SCC1 cell line with curcumin as well as with a post-curcumin salivary supernatant showed a reduction of their IKKb kinase activity It has also been suggested that antitumor activity of curcumin ... the activation of MAP kinases (especially ERK) and NF-jB that consequently down-regulate the mRNA expressions and activities of proteolytic enzymes, such as urokinase-type plasminogen activator ... for new therapeutic approaches in mobile tongue cancer Cancer Med 2012;1(2):128–40 Vissink A, Jansma J, Spigkervet FKL, Spijkervet FK, Burlage FR, Coppes RP Oral sequelae of head and neck radiotherapy...

Ngày tải lên: 01/07/2014, 13:23

... configurations or anti- HIV shRNA and siCheck plasmid having the TGF-b target site (A) or vice versa (B) Dual Luciferase assay was performed as described in Materials and Methods As seen in the figure ... function as a TAR decoy as well as function in RNAi Figure anti- rev TARmiR configuration I can function as siRNA in RNA interference: HEK 293 cells were co-transfected with CMV RevEGFP and the anti- HIV ... end-labeling reaction, TARmiR RNA was 5’ labeled with [g-32P]ATP (7000 Ci/mmol; MP Biomedicals) and T4 polynucleotide kinase as previously described [27] Dual luciferase assays HEK 293 cells were transfected...

Ngày tải lên: 12/08/2014, 04:21

... fibrosis Gastroenterology 2005, 128:108-120 Greupink R, Bakker HI, Reker-Smit C, van Loenen-Weemaes AM, Kok RJ, Meijer DK, Beljaars L, Poelstra K: Studies on the targeted delivery of the antifibrogenic ... MR, Kliewer SA: Regulation of cyp3a gene transcription by the pregnane x receptor Annu Rev Pharmacol Toxicol 2002, 42:1-23 Marek CJ, Tucker SJ, Konstantinou DK, Elrick LJ, Haefner D, Sigalas C, ... 2009, 8:1 4A3COOHmethyl was most likely associated with a lack of expression of the PGRMC1 target in liver myofibroblasts in vivo in contrast to in vitro activated myofibroblasts This underscores...

Ngày tải lên: 13/08/2014, 13:20