Role of protein misfolding pathway in HBX induced hepatocellular carcinoma

... Bhagwat SV, Biswas G, Anandatheerthavarada HK, Addya S, Pandak W & Avadhani NG (199 9) Dual targeting property of the N-terminal signal sequence of P450 1A1 Targeting of heterologous proteins to ... open N-terminal signal domain is critical for protein targeting to the ER (Fig 2D) In contrast to the targeting of CYP 1A1 requiring N-terminal truncation, w...

Ngày tải lên: 18/02/2014, 16:20

... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino ... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the m...

Ngày tải lên: 19/02/2014, 13:20

... well as NO production Accordingly, we concluded that the enhancing effect of TS on LPS/IFN -induced NO production is caused by enhancement of iNOS protein induction Effects of a-T and its derivatives ... amphiphilic structure of the polar carboxyl moiety and the hydrophobic isoprene moiety The enhancing effect of TS on LPS/IFN -induced NO production was inh...

Ngày tải lên: 22/02/2014, 04:20

... for N2C2 and N2Cc In conclusion, the accessibility of the active site was better in the protein bearing the N2 domain than in the protein bearing the Nc domain Thus, the accessibility of the active ... both the N-terminal and C-terminal domains of hoPLRP2 contributed to the stability of the protein in the presence of the water–lipid interfac...

Ngày tải lên: 16/03/2014, 06:20

... bridging the A and G b-strands of the I27 protein during the main unfolding barrier.[39] To further validate this view and gain insight into the role of solvent hydrogen bonds in protein unfolding, ... separating b-strands In Figure B, we define the pulling coordinate for the A and G b-strands as the distance between the first amino acid of strand...

Ngày tải lên: 22/03/2014, 18:20

... protein–RNA and protein–protein interactions in virus stability, measuring the effects of urea, GdnHCl and high pressure on the structure and stability of whole particles (bacteriophage MS2 and ... the role of protein–protein and protein–RNA interactions in virus stability is not completely understood, and we have investigated these questions in...

Ngày tải lên: 30/03/2014, 11:20

... that both ADAM10 and TACE are involved in the shedding of APP, neither ADAM is involved in the shedding of ACE Furthermore we show that APMA can distinguish between the shedding of ACE and APP ... would appear that ADAM10 and TACE are not critically involved in the shedding of ACE APMA has been reported to induce the shedding of a number of pro...

Ngày tải lên: 30/03/2014, 14:20

... bronchial and bronchoalveolar lavage studies have provided evidence of increased levels of cysteinyl leukotrienes in the airways of asthmatic individuals.7 Mast cells synthesize and release leukotrienes ... However, they are not as effective as inhaled ␤2 agonists are in the management of EIB.12 Other Agents Anticholinergics, antihistamines, ␣ agonists, and oral ␤2 agonists ha...

Ngày tải lên: 08/08/2014, 20:23

... into antigen-induced arthritis (AIA) mice at day After 24 hours radioactivity in isolated organs and the rest of the body was determined using a γ-counter Thereafter, the total radioactivity recovered ... cells after arthritis induction is not effective On the one hand, transfer of Treg cells 24 hours after intra-articular antigen challenge might be too late to inhib...

Ngày tải lên: 09/08/2014, 06:22

... YJ, Li HZ, Tian Y, Lv YJ, Yang BF, Xu CQ: Involvement of calcium-sensing receptor in cardiac hypertrophy -induced by angiotensinII through calcineurin pathway in cultured neonatal rat cardiomyocytes ... activation of dopamine D receptors significantly inhibit apoptosis induced by ischemia /reperfusion injury Intracellular calcium is regarded as a trigger for cardiomyo...

Ngày tải lên: 10/08/2014, 05:21

... Role of Wnt canonical signaling in carcinomas Wnt canonical signaling is involved in pathogenesis of several carcinomas and the mechanisms of its over-activation are varied Dysregulation of Wnt/ b-catenin ... between canonical Wnt signaling pathway and angiogenesis of carcinomas b-catenin accumulation has been involved in angiogenesis in brain cancer b-catenin...

Ngày tải lên: 10/08/2014, 22:21

... delineated role of PIMs by comparing LPS-induced lung inflammation and mortality in BDL rats and GCtreated BDL rats The dramatic finding was 100% and 80% survival in BDL rats that were treated with ... AC: Quantitation of eosinophil and neutrophil infiltration into rat lung by specific assays for eosinophil peroxidase and myeloperoxidase Application in a Brow...

Ngày tải lên: 12/08/2014, 14:20

... complex process involving several actors, including signaling pathways like the Notch pathway Further work is required to understand the complexity of Notch signaling during cartilage pathology and ... recently reported expression of Notch family members in adult and even OA cartilage raised the issue of the involvement of this pathway in the physiopathol...

Ngày tải lên: 12/08/2014, 15:22

... the need in understanding the role and interaction of PLD with other TNFα signaling mediators PKC The role of PKC (Protein Kinase C) in TNFα induced signaling and responses in a variety of cells ... inflammatory role of PLD in TNFα -induced signaling and responses Recent studies were more conclusive and detailed about the role of PLD in...

Ngày tải lên: 11/09/2015, 16:06

... ROLE OF PROTEIN MISFOLDING PATHWAY IN HBX- INDUCED HEPATOCELLULAR CARCINOMA (HCC) TAN SU YIN (B.Sc.(Hons.), NTU) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF MEDICINE ... consisting of the constitutive form of the heat shock 70 kDa protein (hsc70), the heat shock protein of 40 kDa (hsp40), the heat shock protein of 90 kDa (hsp90),...

Ngày tải lên: 12/10/2015, 17:33