Nanoparticles of biodegradable polymers for gene therapy of hepatitis b

... NANOMEDICINE: MULTIFUNCTIONAL NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER TREATMENT LIU YUTAO (B.Sc., Fudan University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... development of cutting-edge nanoparticles of biodegradable polymers with overall fascinating performance demonstrates the progress in the field of nanomedicine for cancer treatment viii NOMENCLATURE ... 173 LIST OF PUBLICATIONS 193 vi SUMMARY Multifunctional nanocarriers have been regarded as potent candidates for efficient cancer nanomedicine Nanoparticles of biodegradable polymers...

... MULTIFUNCTIONAL NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DIAGNOSIS AND TREATMENT OF CANCER PAN JIE (M ENG., TIANJIN UNIVERSITY) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... nanoparticles of biodegradable polymers for QDs formulation for targeted and sustained imaging for cancer diagnosis at its early stage Two polymers of poly(lactide)-vitamin E TPGS (PLA-TPGS) and vitamin ... loading QDs for targeted and sustained imaging for cancer diagnosis at its early stage 4) to prepare biodegradable polymeric multifunctional nanoparticles for targeted chemotherapy and imaging...

... (PLGA/MMT) nanoparticles decorated by trastuzumab for targeted chemotherapy of breast cancer Biomaterials 2008; 29(4): 475-486 Sun B, Feng SS Trastuzumab decorated nanoparticles for targeted chemotherapy ... conjugation of trastuzumab on NP surface for targeted drug delivery Experiments were carried out to investigate the feasibility of the obtained NPs for targeted delivery of small molecule drugs The trastuzumab ... objective of this research is to study the effectiveness of two systems of trastuzumabfunctionalized nanoparticles for targeted drug delivery In the first part, a novel system of trastuzumab- decorated...

... PACLITAXEL LOADED NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER CHEMOTHERAPY KHIN YIN WIN (M Sc., NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMICAL ... potential analysis of various formulations of paclitaxel- loaded PLGA nanoparticles 81 Figure 13 XRD analyses of paclitaxel, TPGS, blank PLGA nanoparticles and paclitaxel- loaded PLGA nanoparticles ... of paclitaxel- loaded PLGA nanoparticles, fluorescent PLGA nanoparticles and standard PS nanoparticles 133 Table Surface chemistry of the formulation materials and the paclitaxel- loaded PLGA nanoparticles...

... with the simplicity and advantageous arrangement of the retroviral genome, which has made retroviruses so attractive as vectors for gene therapy [11,12] The principal feature of the retroviral ... means that the major safety issue faced by those wishing to use retroviral vectors is that of insertional mutagenesis and oncogene activation Insertional mutagenesis and oncogene activation As ... that further efforts need to be made to assess and reduce the rate of transfer of retroviral genes Oncogene capture The mechanism of oncogene capture appears to be dependent on the generation of...

... Backbone and Hyaluronic Acid Side Chains for DNA Carrier Atsushi Maruyama and Yoshiyuki Takei Introduction Polycations have been used as nonviral gene carriers because the polycations and DNAs form ... known to be taken up and metaboFrom: Methods in Molecular Medicine, vol 65: Nonviral Vectors for Gene Therapy Edited by: M A Findeis © Humana Press Inc., Totowa, NJ Maruyama and Takei lized by ... Nazarova, O., and Seymour, L W (1996) Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers Hum Gene Ther 7, 2123–2133 11 Kabanov, A V and Kabanov,...

... paper) Gene therapy Laboratory manuals Genetic vectors Laboratory manuals Transfection–Laboratory manuals Viral genetics–Laboratory manuals I Machida, Curtis A II Series [DNLM: Genetic Vectors Gene ... and use of viral vectors for gene transfer and gene therapy I would like to thank the many chapter authors for their contributions They are all experts in various aspects of viral vectors, and ... Virus Type 1-Based Vectors for Gene Delivery to Human Hematopoietic Stem Cells Ali Ramezani and Robert G Hawley 467 Semliki Forest Viral Vectors for Gene Transfer Jarmo Wahlfors and Richard...

... a foreign gene can be expressed in the context of a HCMV amplicon viral stock in infected HF cells To test the utility of the HCMV amplicon in gene therapy or gene delivery, we used packaged amplicons ... cells Advantages for use of the HCMV amplicon Foremost among the advantages of the vector system we have described is the potential ability to efficiently infect and deliver genetic information to ... observed in HSV amplicons using Southern blot hybridizations [15] Expression of heterologous genes in an HCMV amplicon To demonstrate that the HCMV amplicon could be used as a vector system to support...

... Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, Kitamura T, Kodama T, Fukayama M, Aburatani H: Identification of Toll-like receptor as a potential therapeutic target in clear cell renal cell carcinoma ... polyethyleneiminederived nanoparticles as a gene therapy delivery system for renal cell carcinoma Journal of Translational Medicine 2011 9:46 Submit your next manuscript to BioMed Central and take full advantage of: ... murine macrophage cell line, Ana-1, and a human umbilical vein endothelial cell line (HUVEC) respectively As a result, the toxicity of PCFC-g-PEI and FA-PEAs on Ana-1 and HUVEC cells was homoplastic...

... Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, Kitamura T, Kodama T, Fukayama M, Aburatani H: Identification of Toll-like receptor as a potential therapeutic target in clear cell renal cell carcinoma ... polyethyleneiminederived nanoparticles as a gene therapy delivery system for renal cell carcinoma Journal of Translational Medicine 2011 9:46 Submit your next manuscript to BioMed Central and take full advantage of: ... murine macrophage cell line, Ana-1, and a human umbilical vein endothelial cell line (HUVEC) respectively As a result, the toxicity of PCFC-g-PEI and FA-PEAs on Ana-1 and HUVEC cells was homoplastic...