THE ROLE OF ANNEXIN 1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES

... 11 6 11 9 4 .1 The role of Annexin- 1 in the regulation of inflammatory stress 11 9 response 4.2 Conclusion 14 4 4.3 Limitations of the study 14 5 4.4 Future work 14 6 Bibliography 14 8 Summary Annexin- 1 ... for investigation of the basis of the inflammatory stress response The aims of this study are thus, 1) To determine the role...

Ngày tải lên: 01/10/2015, 17:27

... for my study The role of sentence stress in enhancing English speaking competence of HPU English majors A survey within the scope of the study is conducted at HPU The major aim of the study is ... clear to you The role of sentence stress in enhancing English speaking competence Sentence stress is the governing stress in con...

Ngày tải lên: 17/03/2014, 16:12

... tagging for relative and absolute quantification IAA Iodoacetamide ICAT Isotope-coded affinity tagging K0R0 12 C 614 N2-lysine and 12 C 614 N4-arginine K8R10 13 C 615 N2-lysine and 13 C 615 N4-arginine ... Annexin 1. 2 .1: Structure of ANXA1 ANXA1 is one of the members of the annexin superfamily of 13 members (A1-A13) All members of this superfamily have the same principal...

Ngày tải lên: 10/09/2015, 09:04

... FEBS 5277 Nectin -1 mediates HSV -1 entry into RPE cells V Tiwari et al Fig Role of nectin -1 during HSV -1 entry into RPE cells (A) Antibody against nectin -1 significantly inhibits HSV -1 entry into cultured ... stained CHO-HVEM RPE D Events B 11 4 A C 10 1 10 2 11 9 10 0 10 3 10 4 FITC stained CHO -nectin -1 Events RPE 10 0 10 1 10 2 FITC 10 3 10 4 Fig...

Ngày tải lên: 18/02/2014, 14:20

... triiodothyronine (T3) and thyroxine (T4) and the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatine kinase (CK) and lactate dehydrogenase ... unrestrained heat- acclimated rats Measurement of these variables without the confounding effects of restraint or handling has increased the validity of the rat as a model fo...

Ngày tải lên: 11/09/2015, 21:52

... requires protein translocation to the nucleus Although functional analyses of individual domains have not been addressed, the global context of the domain analyses allows us to draw a more general ... 0.75 are shown Black geometrical shapes are additional domains, as indicated ANOGA, Anopheles gambiae; ASHGOS, Ashbya gossypii; BRARE, Brachydanio rerio; CANDGLA, Candi...

Ngày tải lên: 07/03/2014, 21:20

... m wt )11 9/ +17 8 )11 9/ +14 3 )22/ +17 8 )22/+4 10 0 73 91 23 21 ± 10 ± 3.4 ± 2.6 10 0 13 3 10 0 15 0 ± ± ± ± 12 10 10 m ± ± ± ± 30 20 20 70 70 28 ± ± ± ± 20 not examined which sequences in the )11 8/)35 ... site(s) (A) Effect of point mutations in Ets and Sp1 motifs on PS1 promoter activity The positions of Ets (d) and Sp1 (h) motifs in the )11 9/ +17 8 reg...

Ngày tải lên: 16/03/2014, 18:20

... Colosia AD, Donahue JP, Lin YZ, Hawiger J: Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization ... stress-activated protein kinases, also called cJun NH2-terminal kinases (JNKs); and the p38 MAPKs [13] The JNK pathway is of interest because of its capacity to phosphorylat...

Ngày tải lên: 09/08/2014, 07:20

... required for the expression of many cytokines involved in the pathogenesis of acute lung injury [26–35] In acute lung injury caused by infection of bacteria, cytokine receptors HIF-1 consists of two ... function play a central role in initiating the innate immune system and in activating NF-κB Anti-inflammatory cytokines have the ability to suppress inflammat...

Ngày tải lên: 12/08/2014, 19:21

... over-expression of p21WAF1 inhibits DNMT1 73 3 .1. 1.7 TSA -mediated induction of p21WAF1 results in inhibition of 76 DNMT1 3 .1. 1.8 TSA -mediated induction of p21WAF1 is independent of p53 85 3 .1. 2 Transcriptional ... between DNMT1 and p21WAF1 in the 63 cell cycle 3 .1. 1 .1 3 .1. 1.2 DNMT1 expression in the cell cycle 63 WAF1 in DNA 67 p21WAF1 68 Tran...

Ngày tải lên: 14/09/2015, 14:13

... confirmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell cycle ... proteins with the promoter E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85] Another E2F site distal to the E2F ⁄ CDE acts...

Ngày tải lên: 16/02/2014, 09:20

... were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O2 Culture medium was replaced every other day inside the chamber For miRNA transfection, ... were treated as described in (A) Total RNA was prepared at the indicated times and subjected to quantitative real-time PCR analysis The data shown are mean value ± standard err...

Ngày tải lên: 18/02/2014, 08:20

... evaluation of heme dynamics in cultured cells Role of heme metabolism in cellular heme content Regulatory role of free heme in expression of HO-1 To evaluate the contribution of heme synthesis and ... HO-1 protein was also induced by the treatment with HO-2 siRNA in HepG2 cells These results indicate that the down-regulation of HO-2 expression is...

Ngày tải lên: 19/02/2014, 05:20

... side-chains are important for the GABA transport activity 1- Deoxymannojirimycin inhibits the GABA- uptake of GAT1 In order to gain further insight into the role of the terminal structures of the N-glycans ... N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT...

Ngày tải lên: 19/02/2014, 17:20

... raise the possibility that GSK3 may help to coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin ... Effects of insulin, Li and SB-415286 on signalling elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and...

Ngày tải lên: 08/03/2014, 08:20