... Sentence stress organizes the words inthe sentence into logically connected thought groups by joining the unstressed syllables to the main stressed syllable inthe group and marking the end ofthe ... lose their stress. The most important words in the sentence receive stronger stress. The last stressed word inthe sentence receives the strongest stress with the help of falling or rising intonation. ... distinguish between four levels of stress: major sentence stress, major word stress, minor word stressand unstressed. Thus, inthe sentence: “I walked home inthe rainstorm”. ‗I‘, in , and...
... from the ventral and paratendinous portion leading into the Achil-les tendon body. In patella tendinopathy these neovesselsoften arise inferior to the patella from the Hoffa fat padentering the ... neovascularisation and increased cellularity [1,2]. The severity of these tendonchanges encountered in tendinosis was quantified [3], and the importance ofthe ongoing process and cause of increased ... or in tendinopathies at the wrist level. The diagnosis of tendinopathy ofthe main body of the Achilles tendon is made if patients have Achilles tendonpain at rest or at exercise inthe main...
... ). The renewed interest in examining the indications for BCG vaccination in the United States included consideration ofthe wide range of vaccine efficacies deter-mined by clinical trials and ... toexplore the sources ofthe heterogeneity inthe efficacy ofthe BCG vaccine reported in the individual studies. Using a model that included the geographic latitude of the study site andthe data ... resurgence inthe incidence of TB occurred inthe UnitedStates and included increases inthe number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving...
... involved inthe regulation of the stability and trafficking of GAT1. It has beenreported that a variety of molecular chaperones and folding enzymes assist the folding of newly synthesizedproteins in ... N-linked oligosaccharide side-chainsare important for the GABA transport activity.1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into theroleof the terminal ... clarifywhether N-glycans are directly involved inthe GABA-uptake process and whether the modulation of N-gly-cosylation in uences the biochemical properties of thisprotein, quantitative and kinetic...
... most of them and access-to-input for the worst in this sub-pool. Conversely, the overbearing influence ofthe financial constraints in the lower half is statistically associated with a rather ... book, index of current production, the lower the supply of credit. Finally, the higher the co-ordinate on the f2 axis, e.g. the more the enterprise is faced with financial limit, the higher the ... The probability of increasingdebt raises with the fact that the enterprise was indebted inthe past (in all the groups).Nodebt thus appears as a strong inertial component inthe credit-demand...
... affinity of ChiB for allosamidin, which is ananalogue ofthe proposed oxazolinium ion intermediate [32]. The minor (or even positive) effects of Y214F on substrate and intermediate binding andthe ... conformations. The Asp142 equiv-alent inthe family 18 chitinase from Coccidioides immitiswas found to be inthe ÔdownÕ position inthe apoenzyme and inthe ÔupÕ position inthe complex with allosamidin ... for the position of residue 142 [34]. The pKacalculations indicate that the only candidate fora residue determining the basic arm ofthe pH-activityprofile ofthe D142N mutant is Glu144. The...
... 2010)doi:10.1111/j.1742-4658.2010.07685.x The hyperthermostable chitinase from the hyperthermophilic archaeonPyrococcus furiosus has a unique multidomain structure containing two chi-tin-binding domains and two catalytic domains, and ... Stereo figures ofthe model ofthe bound substrate inthe AD2 E526A mutant (A) and D524A mutant (B). The structures of boundsugars andthe side-chains of three acidic residues inthe conserved ... important rolein ‘cycling’ the pKa of catalyticGlu during catalysis [24,38]. The mutation ofthe D1residue to Asn (D140N) in SmChiB caused a 500-folddecrease in activity [39]. On theother hand,...
... ER81 and PEA3), ER81 and ERM being the most related [35]. PEA3 members all contain the highlyconserved ETS domain. ERM contains two DNA bindinginhibitory domains flanking the Ets domain: the ... transcription ofthe humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The roleof Ets factors inthe regulation of presenilin 1Martine Pastorcic1 and Hriday K. Das1,2,31Department of Pharmacology ... inthe extract as aninternal standard. The activity of ()119/+178) PS1CAT inthe pres-ence ofthe empty vector was taken as 100%. The values represented in the graph are indicated below. In...
... these residues in binding the carboxylate linked to the nucleus of penicillin N(Arg160 and Arg162) andthe carboxylate ofthe a-amino-adipoyl side-chain (Arg266). The results for mutation of Arg74 ... 160,162, 266, 306 and 307) that, together with the crystallo-graphic analyses, support the proposed roles for arginines160, 162 and 266, and suggest roles for theother arginineresidues.Scheme ... Taiwan;3Department of Pharmacy and Pharmacology, The University of Bath, UKDeacetoxycephalosporin C synthase (DAOCS) catalyses the oxidative ring expansion of penicillin N, the committed step in the biosynthesis...
... involved inthe reaction. An analysis of the active sites of DHBD structures inthe presence andin the absence of substrates andofthe structure of P. putida C2,3O suggests a possible hypothesis. ... Appar-ently, the close contacts between these two residues and the edge ofthe substrate ring could prevent bind-ing of 3,6-DMC and 3,5-DMC, as shown in Fig. 2-D,E,F. Thus, the binding of 3,5-DMC and ... 3,6-DMC.Interestingly, the progressive decrease ofthe dimen-sion ofthe residue 249 side chain also causes anincrease inthe Kmvalues for catechol and 3-MC(Fig. 4A). Inthe case ofthe smaller...
... further examined with the relevant economic theories which are introduced inthe Chapter 2 ofthe thesis. By applying economic theories, the roles and mechanisms of international agreements in ... impact of trade agreements mathematically in terms of environmental conservation. The proposed thesis is, therefore, unique, original and very challenging in this aspect. The followings are ... especially on trade. Some ofthe evidences will be derived from interviews and the diplomatic experiences ofthe author ofthe thesis. 4. Scope of Study (1) International Aspects First,...
... dispersion ofthe growth rates ofthe state hous-ing index when the states economies are in recessionary phase ofthe business cycle.This suggests that the housing market across states converges during ... business cycle. The national economy was in expansion during the 1989:IQ until the 1990:IIQ, then it was in recession from the 1990:IIIQ to the 1991:IQ and went back to expansionary phase inthe ... 11unemployment, and for the rest ofthe states unemployment rate decreased. Similarly,during the 2001 recession, which began inthe fourth quarter of 2000 and continueduntil the end of 2002, aggregate...
... establish the consistency withwhich discriminations are made.Both Norman and Wyrwich raise the interesting issue of what constitutes a meaningful discrimination, and whether Delta is an index of such ... remains to be seen how these ele-ments, particularly reliability and discrimination, interact. In closing I should directly answer the questions posed byNorman and Wyrwich inthe titles of their ... Matthew Hankins - matthew.hankins@kcl.ac.ukAbstractA response to Norman GR 'Discrimination and reliability: equal partners?' and Wyrwich KW'Understanding theroleof discriminative...
... complex leads to the initiation of complex signaling events leading to proteintyrosine phosphorylation and activation ofthe src-familykinases Lyn and Fyn as well as the tyrosine kinase Syk[30,32,52]. ... the processing of the amyloid precursor protein (APP) [12-14]. These datasupport the potential utility of anti-inflammatory drugtherapies inthe treatment of AD.Microglia are the principle immune ... reduction in ROS is likely aconsequence of statin inhibition of Rac prenylation result-ing inthe inability of Rac to interact effectively to form the NADPH oxidase complex or RhoGDI. The use of statins...