... Yingzhu and Wang Runzhi, for their care and support in Singapore I am deeply indebted to my parents for their unconditional love and to my wife Dr Han Zheng for her understanding, support, and loving ... storing models For instance, the BioModels database (Le Novere et al., 2006; Li et al., 2010) archives more than 200 published ODE models covering many of the known biological pathways ODE models ... analysis techniques, namely, sensitivity analysis, and perturbation optimization 2.1 Biological Pathways Cellular processes are driven by networks of biochemical reactions, termed biological pathways...