DEVELOPMENT OF HUMAN IN VITRO MODELS FOR PREDICTING ORGAN SPECIFIC TOXICITY

... types for developing in vitro models for predicting organ- specific toxicity Immortalized cell lines such as the standard murine fibroblast cell line NIH/3T3 are commonly used in toxicity testing ... human 18 induced pluripotent stem cell (hiPSC)-derived HPTC-like cells for the development of in vitro models.   19 1.4 Role of inflammation in drug-induced...

Ngày tải lên: 30/09/2015, 06:22

... ultimate goal was to use this loading- measurement system to measure and compare the relative 3D biomechanical characteristics of intact and two Association for the Study of Internal Fixation (ASIF) ... compliment application of ASIF devices along the distal aspect of the lateral and cranial (anterior) radius surfaces with at least a 0.5 cm distance from potting material, a...

Ngày tải lên: 20/06/2014, 01:20

... Effect of inhibitors on in vitro processing Inhibitor Name Concentration Inhibit Cleavage Metalloproteinase Aspartic acid proteinase Serine proteinase Cysteine proteinase EDTA Pepstatin PMSF ... Processing Kinetics of Core Protein Precursors To determine the optimal temperature and kinetics of processing of the core protein precursors in the in vitro cleavage...

Ngày tải lên: 19/06/2014, 08:20

... Effect of inhibitors on in vitro processing Inhibitor Name Concentration Inhibit Cleavage Metalloproteinase Aspartic acid proteinase Serine proteinase Cysteine proteinase EDTA Pepstatin PMSF ... Processing Kinetics of Core Protein Precursors To determine the optimal temperature and kinetics of processing of the core protein precursors in the in vitro cleavage...

Ngày tải lên: 20/06/2014, 04:20

... score measured in a prespecified time interval, and mean SOFA was always calculated by taking the average of all total SOFA scores in the prespecified time interval These intervals varied in length, ... ICU stay found an AUC of 0.79, which was almost the same as the AUC for a single SOFA-score at admission [17] A high delta SOFA indicates increasing organ dysfunction...

Ngày tải lên: 13/08/2014, 11:23

... clinical data concerning the individual patient, particularly information relating to biomarkers However, translational integration of this large amount of information into one risk assessment is a ... can hardly be repeated with distinct cohorts Whereas the predictive power of any single variable including tumour size was limited, integration of molecular information into a u...

Ngày tải lên: 13/08/2014, 16:20

... flexibility allows the machine, when it is not performing PEB of wafers, to maintain the heaters at a setpoint temperature 2.3.3 In- situ Temperature Measurement System The in- situ temperature measurement ... ascertaining the effect of poor feedback signal on control performance, a simple single-input single-output control system was used Instead of multi-zone heating, th...

Ngày tải lên: 04/10/2015, 15:53

... ”want in answer ”adenocarcinoma” in question ”was” in question ”live” in answer Q avg pos votes ”would” in answer ”answer” in question ”just” in answer ”me” in answer ”be” in answer in the” in question ... 2000 Information retrieval on the web ACM Computing Surveys, 32(2) Y Liu, J Bian, and E Agichtein 2008 Predicting information seeker satisfaction in communi...

Ngày tải lên: 20/02/2014, 09:20

... the early trophoblast of the attachment phase or as later invasive stage [46–48] Thus, in most cases, choriocarcinoma has the appearance of trophoblast, being predominantly syncytiotrophoblastic ... cytotrophoblastic Some cytotrophoblastic choriocarcinomas secrete little human chorionic gonadotropin and some choriocarcinomas also secrete human placental lactogen [22–27] A number o...

Ngày tải lên: 20/02/2014, 23:20

... culture of infected hepatocytes To succeed in obtaining HCV infection in primary human hepatocytes, an existing model of hepatitis B virus infection was used to determine optimal infection conditions ... hepatocytes and lymphocytes in vitro In summary, use of HCV-containing sera to reconstitute the entire life cycle of HCV in vitro has proved to be very d...

Ngày tải lên: 16/03/2014, 05:20

... human resource development in Tourism in the South Central Coast and Highlands The development of human resources in Tourism in the South Central Coast and Highlands has good quality and meets requirements ... of human resources in Tourism in the South Central Coast and Highlands during the period of 2001 – 2009 -...

Ngày tải lên: 09/07/2014, 13:29

... The data used in this work were collected as part of a larger project that examined patterns of below- and above-ground biomass in Eucalyptus populnea woodland ecosystems along a rainfall gradient ... the model of Ammer and Wagner [2] for predicting FRB pools in compositionally diverse woodland vegetation from contrasting climatic regions in northeast Australia...

Ngày tải lên: 07/08/2014, 16:20

... induction of MMP-1 and MMP-3 in cartilage and SFB by TNFα and/or IL-1β [42,43] Therefore, they support the validity of the new model for the analysis of the mechanisms of cartilage destruction by SFB ... inhibition of the caseinolytic activity in zymography by EDTA and lack of inhibition by the serine protease inhibitor phenylmethylsulfonyl fluoride further confi...

Ngày tải lên: 09/08/2014, 01:22

... regulating IVD cell behaviour In this study, we have examined the relative influence of serum, glucose, and oxygen supply, singly or combined, on the growth pattern of bovine IVD cells Since the nutrient ... levels of oxygen and in medium supplemented with 20% FCS and 320 mg/dL glucose Cell proliferation and cell viability Monolayers were harvested by tr...

Ngày tải lên: 09/08/2014, 10:23

... Poly I:C ( g) Figure Poly(I:C) induces a dose dependent influx of inflammatory cells into the airways of mice Poly(I:C) induces a dose dependent influx of inflammatory cells into the airways of ... results in increased expression and/ or secretion of pro-inflammatory cytokines including IL-6, CXCL-8, CCL-2, CCL-5, CXCL-10, GM-CSF, TNF and IFN A likely source of cytokines...

Ngày tải lên: 12/08/2014, 14:20