Investigating the molecular basis of siah1 and siah2 e3 ubiquitin ligase substrate specificity

... Molecular Basis of Siah2 Substrate Specificity Given the different roles of Siah1 and Siah2 in cancer and their different cellular functions, it is important to understand the structural basis ... Furthermore, it was found that the amounts of PHD3 bound to full length Siah2 and the SBD of Siah2 were similar The comparable binding of PHD3 to full l...

Ngày tải lên: 23/09/2015, 14:47

... accumulation of mutations, loss of apoptotic control and regulation of cell proliferation, and the appearance of aneusomy are associated with worsening dysplasia phenotypes and may reflect underlying dysregulation ... characterized by genetic abnormalities, phenotypic changes and clonal overgrowth throughout the lungs [60] Measures of genomic instability follow rates of l...

Ngày tải lên: 12/08/2014, 18:21

... with the PCR products of the deletions and another round of PCR was performed using P14 and the respective primers P16, 17 and 18 to obtain the final constructs as shown in Figure The sequences of ... template These PCR products were then gel purified To fuse the Igκ and FLAG to the N-terminal of εSG, the PCR product containing the Igκ , FLAG and a small po...

Ngày tải lên: 05/10/2015, 21:24

... cDNA sequences of PsHO1 indicating the location of intron-exon boundaries The position of the mutation in pcd1 causing premature chain termination is indicated Numbers refer to the first and last ... seedlings This band was completely absent in pcd1 seedlings consistent with the presence of the premature translation termination codon in the mutant gene The p...

Ngày tải lên: 30/03/2014, 11:20

... gland of the brain, and the pattern of synthesis and release of these hormones changes in an age-dependent manner In virtually every species, the degenerative changes associated with aging are ... Congress Cataloging-in-Publication Data Clark, William R., A means to an end : the biological basis of aging and death / by William R Clark p cm Includes...

Ngày tải lên: 11/06/2014, 05:26

... Tsix The role of DNA methylation Figure Transcription of Xist and Tsix on the X chromosome The coding sequences of Xist and Tsix overlap on opposite strands of the X-chromosome DNA effect: the ... initiated A second cause of non-random X-chromosome inactivation is the selective death of cells that inactivate the incorrect number of X chromosomes: because the fate...

Ngày tải lên: 06/08/2014, 18:21

... Size of growth effect Figure of Analysis the global effects of Cr treatment on the heterozygous mutants Analysis of the global effects of Cr treatment on the heterozygous mutants The plot shows the ... protein may contribute to the intrinsic resistance of the cell to the toxic action of the metal Over-representation of specific Gene Ontology ter...

Ngày tải lên: 14/08/2014, 08:20

... nodes behind the breastbone Or Inflammatory breast cancer is a rare type of breast cancer The breast looks red and swollen because cancer cells block the lymph vessels in the skin of the breast ... dissertation, the author attempt to investigate how ERp29 may regulate another effector of PERK, Nrf2 in breast cancer cell lines The levels of eIFα...

Ngày tải lên: 12/10/2015, 17:35

... placed towards the hydrophobic cavity in the ligand binding pocket, similar to the placement of the cyclopropyl group of CPX in 1RTL The cyclopropyl group is buried in the surface cavity and faces ... towards a hydrophobic cavity in the binding pocket of the HCV protease NS3-4A The cyclopropyl binding mode and the geometry of the cavity appear...

Ngày tải lên: 14/08/2014, 08:20

... measure the mobility of the components in the PGCs The medaka embryo was peeled off the chorion, and the segment containing the part of PGCs was excised for observation by microscopy and FCS ... dynamic nature of the nuage Schematic diagram of the preparation of PGCs of medaka specimen (A) OlvasGFP was expressed in the medaka PGC at stage 24 and...

Ngày tải lên: 18/02/2014, 16:20

... hypophosphatasia, (b) infantile hypophosphatasia, (c) childhood hypophosphatasia, (d) adult hypophosphatasia and (e) odonto hypophosphatasia [1–4] Perinatal and infantile forms of hypophosphatasia are ... Molecular basis of perinatal form of hypophosphatasia N Numa et al Hypophosphatasia is caused by various mutations of the tissue-nonspecific alkaline pho...

Ngày tải lên: 07/03/2014, 05:20

... b-strands instead of eight, with the C and D strands and the intervening loop forming a large loop, exposing some hydrophobic residues in this region that are normally buried on the inside of the ... the protein [98] Dislocation of the C and D strands from their native edge region may result in the formation of a new interface involving A and B strands which...

Ngày tải lên: 07/03/2014, 10:20

... on the mole¨ cular basis of cytokine receptor signalling – theme and variations – has three movements, like a sonata First, we will look at the basic mechanism and the many variations realized ... membrane and are bound together – oligomerized – in the presence of the ligand Recently, evidence has accumulated that some single-span receptor chains can form...

Ngày tải lên: 15/03/2014, 09:20

... that the amino group at carbon of the guanine ring may interact with the side chain of Glu309, whereas the carbonyl group at position of the guanine ring may interact with the hydroxyl group of the ... structures of the EhPGK obtained using the modeller program (Fig S1), it was found that the only difference in the amino acids that bind the purine ring was...

Ngày tải lên: 16/03/2014, 01:20