... and methods sufficient protein may contribute tothe intrinsic resistance ofthe cell tothe toxic action ofthe metal Over-representation of specific Gene Ontology terms in the annotations of ... Size of growth effect Figure of Analysis the global effects of Cr treatment on the heterozygous mutants Analysis ofthe global effects of Cr treatment on the heterozygous mutants The plot shows the ... as models to further our understanding of cellular metal toxicology, and because ofthe importance of metal toxicity in microbial biotechnologies [4-7] Chromium toxicity is an issue of especially...
... autoimmune diseases, cancer and transplant rejection Both the innate and adaptive components ofthe host response are complex, and the interaction between the two represents another level of ... of some signals to Zone Portals are a means of transferring agents and signals from one zone to another They are randomly placed in Zones and The variation and uncertainty ofthe time spent by ... lists the simulated signals within themodel and the cytokines/ chemokines that they are intended to represent These are not meant to be exhaustive lists Table lists the behaviors for all of the...
... leading to build-up of NADH, which was not expected, as the levels of cofactor should be sufficient to sustain the lactate flux Therefore, there must be an additional factor acting as an inhibitor of ... Examination ofthemodelofthe R state of LDH shows a much higher density of positive charge in the region of contact between the monomers than in LDHB, particularly in the region of contact ... interpolations the impact of these lactacte dehydrogenase features on the physiology ofthe organism The metabolism of glucose was monitored by in vivo 13C-NMR under 5928 anaerobic conditions Cells of strain...
... promotion of cell proliferation and cell growth can together mimic the effects of activated Ras, the two groups overexpressed the transcription factor E2F together with its binding partner Dp, to promote ... proliferation, and the phosphatidylinositol 3-kinase Akt or the transcription factor Myc, to promote cell growth, in scrib mutant cells Overexpression of any of these effectors alone did not mimic the effects ... aspects of human cancer and metastasis may have parallels in flies, we can expect many exciting new discoveries to be made using flies as a modeltostudy metastasis reviews To test whether promotion...
... hotels and restaurants, quality and variety of food, and shopping facilities and services Zhang and Lam (1999) employed the push and pull factors as a conceptual framework in their studyof mainland ... facilitators or inhibitors ofthe behavior, or CB; and (2) perception ofthe strength ofthe facilitators or inhibitors, or power (P) Statements of these two components were again multiplied and ... in thestudy diminished even though they agreed to take part in the survey However, data from the usable responses were sufficient to achieve the objectives ofthestudyOfthe 299 completed and...
... pathway [20] The intrinsic pathway is characterized by the permeabilization ofthe outer mitochondrial membrane and the release of several pro-apoptotic factors into the cytoplasm For mitochondrial ... inhibits Bax translocation from the cytoplasm tothe mitochondria and promotes survival [45] Anti-apoptotic stimuli lead tothe activation of Akt and to Ser184 phosphorylation of Bax [46] This ... motility The EGFR can transmit signals for re-organization ofthe cytoskeleton, the formation of lamellipodia, membrane ruffling and changes in cell morphology Accordingly, dysregulation ofthe EGFR...
... related to GIH ofthe lobster Homarus americanus [9] than tothe mandibular organ-inhibiting hormones ofthe crab Cancer pagarus [10] MeMIH-A and MeMIH-B are non-sex-specific and are expressed in the ... on the hepatopancreas and ovary to increase the rate of vitellogenin gene expression, indicating that both the hepatopancreas and ovary are the targets of MeMIH-B This result will provide thebasis ... vitellogenin-stimulatory factor of shrimp Because ofthe existence of multiple forms ofthe CHH family neuropeptides, there may be a discrepancy in defining the function of many cDNAs cloned using a molecular...
... distance greater than A 1780 ofthe inhibitor, and the backbone and Cb atoms ofthe inhibitor and those ofthe protein located at a distance ˚ smaller than A ofthe inhibitor, respectively No ... N-domain and C-domain of human, mouse and rat enzymes Themodelofthe N-domain of human ACE (ACE-N) was achieved by homology modeling using the 3D structure ofthe human germinal form of this enzyme ... position of several sets of atoms The harmonic constants were set to 100, and 0.5 kcalÆ ˚ mol)1ÆA)2 for the ions and their chelating residues, the ˚ atoms ofthe protein situated at a distance greater...
... lacking Mutants that are unable to synthesize the phytochrome chromophore have proved to be important in developing our understanding ofthe role ofthe phytochromes in light-regulated plant development ... the hy1 and hy2 mutants of Arabidopsis thaliana [14] and the aurea and yellow-green-2 (yg-2) mutants of tomato [15] Typically, these mutants have elongated stems or hypocotyls, reduced red and far-red ... heme of 3.1 lm compared to 1.3 lm for recombinant AtHO1 [11] and lm for recombinant human HO-1 [38] The strongest dependence of PsHO1 activity was for the presence ofan iron chelator to accept the...
... into slime at a later stage, during storage Even today, this pathogen ranks economically as the most important disease of potato and tomato Fig The symptoms of late blight (Phytophthora infestans) ... disjunction and the changing climate affect the distribution of plants and animals in East Asia The species of postglacial East and South Asia have gone through the process of speciation In the Northern ... distances generated from the bands rather than taking into account the diversity ofthe population The disadvantage is that it treats the data as polymorphism produced by the markers rather than...
... Tsix The role of DNA methylation Figure Transcription of Xist and Tsix on the X chromosome The coding sequences of Xist and Tsix overlap on opposite strands ofthe X-chromosome DNA effect: the ... nature of factors that are involved in the mutual regulation of Xist and Tsix in pre-X-chromosome-inactivation cells are likely to be important in developing an understanding of how these The mechanisms ... transcriptional silencing [15] These epigenetic marks also characterize the XI, and their recruitment tothe XI requires transcription of Xist [16-18] Together, these results suggest that the increase in Xist...
... changes are seen in the transition from normal to intraepithelial cancer to invasive disease The understanding ofthe timing of instability during progression, the rate of instability and the ... Institute, the Damon Runyon Foundation, the Office of Research and Development, and the Department of Veterans Affairs The authors thank Tamara Lasakow for editorial assistance with the manuscript ... deletions as the mechanism of loss of p16 function [27] The relationship between tobacco and the loss of p16 points to new mechanisms involving smoking in the pathogenesis of lung cancer Mutagens...
... group to another, the translator needs to pay attention tothe style, language and vocabulary peculiar tothe two languages in question in order to produce an 'exact' translation ofthe source language ... because they are tight tothe culture and the language community where they originate Therefore, to this type of translation, the function ofthe translation text cannot match with that ofthe ST‘s ... subjectivity and hypercriticism in TQA, Larose reminds the evaluator the necessity to assess a translation ―in terms ofthe appropriateness ofthe translator‘s intention to that ofthe author ofthe original,...
... according to genre and tothe situational dimensions of register and genre A “statement of quality” is then made ofthe translation Finally, the translation can be categorized into one of two ... errors The frequency of their occurences will be the foundation to assess the quality ofthe target text and to challenge House’s idea that to literary work, it has to be an overt kind of translation ... become the concern of Translation Quality Assessment approaches and quite many attempts have been made to find the answer tothe question of how to effectively assess the quality of a translated...
... length Siah2 and Siah2 SBD bind to PHD3 tothe same extent In the IP, the presence ofthe faint band in the empty vector lane is due to non-specific binding of PHD3 The same membrane was reblotted ... MolecularBasisof Siah2 Substrate Specificity Given the different roles of Siah1 and Siah2 in cancer and their different cellular functions, it is important to understand the structural basis ... for the proteins indicated at the top of each panel (a) Cell lysates were subjected to HA-IP and aliquots ofthe cell lysates and immunoprecipitates were analyzed by western blotting with the anti-FLAG...
... β-mecaptoethanol were added directly tothe beads and boiled to elute the bound products without dissociation ofthe antibodies from the beads DTT was then added to 100mM tothe samples analyzed ... Detection of ε-SG in mouse and human tissues (brain) – The cytosolic domain of human ε-SG was used as epitope for the antibody production Hence, to compare the specificity ofthe antibody between human ... Hence, the cytosolic domain of ε-SG was chosen as the antigen of choice for antibody production The GST moiety was cleaved off the GSTε-SG-Cyt to prevent the production of contaminating anti-GST antibodies...
... sufficient to create models which could estimate the effects of noise and light on performance An important point of reference ofthe Ph.d-thesis was that the framework ofthe developed model had to ... improvement ofthe air quality would be better than improving the thermal conditions in a climate like the Northern European The use of both the thermal BN model and the indoor air quality BN model ... as good as the data that forms thebasisofthemodel In the BN models in Paper I and Paper II it was strived to make use ofthe best data available A description ofthe data and the derived...
... AS, NT and KN performed the experiment TY and AS participated in the design ofthestudy YI conceived ofthe study, and participated in its design and coordination and helped to draft the manuscript ... Journal of Orthopaedic Surgery and Research 2009, 4:31 Figure quantitatively measured in theofthe host The size 2of the bone formationlateral view bone was also The size ofthe bone formation ofthe ... model in rats, a preliminary analysis ofthe effect ofthe presence of muscle-covering tothe pasteurized bone graft or the application of FGF-2 to pasteurized bone was carried out in terms of...