... Fig S2 Sequence alignments of PAS- B and PAS- A of NPAS2, PAS- B of HIF2a, a heme-binding PAS domain of BJ FixL and PAS- A of Ec DOS Amino acids at 26 6, 28 9, 300, 3 02, 329 , and 335 with bold H of PAS- B ... 536 534 536 533, 5 62 424 529 , 557 425 424 426 425 426 421 423 (His ⁄ His 6cLS) 427 (His ⁄ Met6 cLS) 434 (His 5cHS) 527 , 530, 531, 530, 530, 559 525 , 420 426 420 420 421 421 421 420 536, 530, 536, ... Journal 27 2 (20 05) 4153–41 62 ª 20 05 FEBS R Koudo et al Spectra of PAS- B of NPAS2 Table Optical absorption spectra (nm) of the wild-type and His mutant proteins of the isolated heme-bound PAS- B domain...