MYCOBACTERIAL DORMANCY AND PERSISTENCE MOLECULAR MECHANISMS CONTROLLING STRESS RESPONSE, SURVIVAL AND ADAPTATION

... characterization of Ngb and Mb at neutral and acidic pH (A) Far-UV CD spectra of human holoNgb and apoNgb dissolved in 20 mM Tris ⁄ HCl and 0.15 M NaCl (pH 7.0) (B) Far-UV CD spectra of human apoNgb and horse ... because, at pH 4.7, the affinity is about 10-fold higher than that of Ngb and Mb at neutral pH and more than 200 times higher than that of Hb...

Ngày tải lên: 07/03/2014, 02:20

... Gas7 and the ERK1 ⁄ signaling pathway in MIH expression H Devaraj and A Natarajan Statistical analysis Mean and standard deviation were calculated Differences between molting stages were analyzed ... signaling pathway in MIH expression H Devaraj and A Natarajan to inhibit ERK phosphorylation, which can be seen as shift in the mobility of ERK2 protein during intermo...

Ngày tải lên: 16/03/2014, 14:20

... Mechanism of CS-induced lung damage and prevention by vitamin C Figure Mechanism of CS-induced lung damage and prevention by vitamin C Mechanism of CS-induced lung damage and prevention by vitamin ... Figure and lung damage caused by intratracheal instillation of p-BSQ in guinea pigs and prevention by vitamin C Apoptosis Apoptosis a...

Ngày tải lên: 11/08/2014, 08:22

... resistant bacteria, and the emergence of new pulmonary pathogens into account, an exact analysis of molecular mechanisms of disease is mandatory to form a rational basis for the development of innovative ... pulmonary innate immune system A large variety of pathogens are known to cause pneumonia The innate immune system serves as the first line host defense system...

Ngày tải lên: 12/08/2014, 16:20

... the molecular mechanisms underlying latency in the monocyte-macrophage lineage is poor Like in CD4+ T cells, two types of latency occur in cells from the monocyte-macrophage lineage Page of 16 ... cells of the monocyte-macrophage lineage However, several mechanisms generating HIV-1 post-integration latency have been described in the monocyte-macrophage,...

Ngày tải lên: 12/08/2014, 23:23

... ATPase domain in its N-terminus, and a peptide binding domain in its C-terminus GRP78 binds to the hydrophobic patches of nascent polypeptides in ER with its peptide-binding domain and uses the energy ... located in an insert region in the middle of the protein kinase domain (Fig 3) Heme binding inhibits HRI kinase activity, and in response to heme deficiency...

Ngày tải lên: 24/08/2014, 11:17

... conformational states of protein under force 21 2. 2 Energy landscape of two state model 21 2. 3 Calculated force-extension curve of folded and unfolded i27 23 2. 4 Calculated ... transitions of protein 20 2. 1.1 2. 1 .2 Force-extension curves of the structural states 22 2. 1.3 Force dependent free energy differences between states 23 2. 1.4 2. 2 Structural states d...

Ngày tải lên: 09/09/2015, 08:13

... in the session of “Inflammatory Mechanisms in Rhinosinusal Disease”.) iv Molecular mechanisms underlying the pathogenesis of nasal polyposis and its response to steroid treatment Content of the ... through the epithelial defect and the mucosa tends to cover it by migration of the epithelium from the edges 23 of the defect; (iii) the pr...

Ngày tải lên: 10/09/2015, 15:49

... B and T cells leading to proliferation and the generation of antibodies (for B cells) and the generation of armed effector T cells such as cytotoxic T cells and helper T cells (Th) (for T cells) ... responses to live and killed bacteria may also provide important insights into the molecular mechanisms of how DC senses microbial pathogens These may hel...

Ngày tải lên: 14/09/2015, 08:24

... spatial and temporal resolution In this thesis, I have studied the molecular mechanisms that regulate the determination of the position of the cleavage furrow and the cleavage furrow formation in cytokinesis ... action Inhibit myosin II ATPase activity by binding to myosin II-ADP-Pi Blebbistatin and inhibit the release of the ADP Inhibit actin pol...

Ngày tải lên: 14/09/2015, 14:09

... curves of CHABII and [Phe21] -CHABII at pH 6.5 (b) Thermal unfolding curves of CHABII and [Phe21] -CHABII at pH 4.0 (c) Thermal unfolding curves of [Phe21] -CHABII at pH 4.0 and [Phe21] -CHABII at ... proteins Extensive 32 CD and NMR experiments were performed to characterize the role of His21 in the pH -induced unfolding of CHABII Thermal unfoldin...

Ngày tải lên: 26/11/2015, 12:54

... III etc ? Adaptation to proteotoxic stress Fig Adaptation to proteotoxic stress by the HSF family in mice HSF1 remains mostly as an inert monomer in unstressed cells, and is converted to an active ... of the mem¨ bers of the mammalian heat shock factor family FEBS J 277, 4126–4139 Morano KA & Thiele DJ (1999) Heat shock factor function and regulatio...

Ngày tải lên: 18/02/2014, 04:20