cellular and molecular mechanisms of methotrexate resistance in melanoma

... prevention of CV events, as well as its cellular effects and molecular mechanisms of action REDUCE-IT is an ongoing, randomized, controlled study evaluating whether the high-purity ethyl ester of EPA ... biologic plausibility of its effects on multiple key atherosclerosis processes Herein, we review the integrated effects of EPA on the cellular and molecular mechanisms of atherosclerotic plaque ... changes in surrogates of interest [3,4] Over the past decade, multiple large, randomized, comparative cardiovascular (CV) trials conducted in statin-treated patients have had disappointing results,

Ngày tải lên: 01/11/2022, 08:56

... November) and Winter (December, January, February) Sampling of Blood Haemoprotozoa for Detection of Blood samples from 324 live pigeons were collected from wing vein using a ml disposable syringe in ... (2004) and Bell et al., (2015) described a Nested PCR assay targeting the cyt b gene of the parasites, for screening and typing of Leucocytozoon sp in parallel with Haemoproteus and Plasmodium in ... Njoku, L., Ihesie, E.K and Etuk, I.F 2012 Study of the haematological and biochemical values and gastrointestinal and haemoparasites in racing pigeons (Columba livia) in Owerri, Imo State, Nigeria

Ngày tải lên: 14/01/2020, 02:12

... was indication of the direct faecal contamination of milk, poor sanitary practices during collection and transportation of milk and further faulty handling process which leads to low standards of ... an upswing in the number of human Listeriosis cases in India, with the reports on sporadic cases and incidence in clinical samples which has been quoted as an emerging foodborne disease in by ... Department of Animal Husbandry, Dairying and Fisheries, Ministry of Agriculture Government of India) Several molecular genotyping techniques such as DNA restriction endonuclease analysis, ribotyping,

Ngày tải lên: 17/06/2020, 13:58

... beta-alanine betaine was discovered in this species and cDNA for beta-alanine N-methyltransferase involved in this pathway is utilized for metabolic engineering of crops for enhanced tolerance to salinity ... PHYSIOLOGY AND MOLECULAR BIOLOGY OF STRESS TOLERANCE IN PLANTS Physiology and Molecular Biology of Stress Tolerance in Plants Edited by K.V MADHAVA RAO Andhra University, India A.S RAGHAVENDRA ... Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500 046 India List of Contributors NAVINDER SAINI Department of Plant Molecular Biology University of Delhi

Ngày tải lên: 12/11/2022, 09:01

... removing the spin restriction and therefore increasing the oxidizing ability of oxygen (Knox and Dodge, 1985; Niyogi, 1999) The half life time of 1O2 is about 200ns in plant cells (Gorman and ... and Molecular Biology of Stress Tolerance in Plants, 157–186 © 2006 Springer Printed in the Netherlands 158 A.R Reddy and A.S Raghavendra biophysical and molecular responses in plant cells under ... to react with DI protein, thus damaging PSII (Trebst et al., 2003) Keren et al (2000) measured the degree of photoinactivation and loss of DI protein by using series of single turnover flashes

Ngày tải lên: 12/11/2022, 09:01

... intracellular ligand-binding proteins: fatty acid-binding protein (FABP5) and cellular retinoic acid-binding protein (CRABP2) Depending on their relative abundance within the cell, FABP5 and CRABP2 ... activator targeting PLZF-binding sites, leading to cellular retinoic acid-binding protein (CRABP1) upregulation The CRABP1 protein is structurally similar to the cellular retinol-binding proteins, sequesters ... independent mechanisms including (1) decreased retinoid uptake; (2) intracellular retinoid metabolism; (3) altered intracellular retinoid availability due to CRAB protein binding; (4) increased retinoid

Ngày tải lên: 03/07/2020, 00:52

... SATB1 expression and clinicopathological features of glioblastoma, and thus the relevance of SATB1 in these tumors, a deeper understanding of the cellular and molecular roles of SATB1 in glioblastoma ... analyze the cellular and molecular role of SATB1 in various glioblastoma cell lines with different SATB1 expression levels, establishing in vitro and in vivo the functional relevance of SATB1 in glioblastoma, ... SATB1 binds and connects so-called “chromatin-remodeling complexes” to DNA and thus functions as a “landing platform” for chromatin remodeling enzymes [5] In this way, SATB1 folds chromatin into

Ngày tải lên: 20/09/2020, 18:59

... treatment induced a marked increase in the size and complexity of the epithelial structures in the mammary glands of ACI rats This response was observed within week of initiation of E2 treatment and ... discernible induction of lobuloalveolar hyperplasia The luminal ectasia was apparent within week of initiation of E2 treatment and remained the predominant feature in the mammary glands of E2 treated ... 6B and 6E) Mmp7 was undetectable in mammary glands of control ACI and BN rats at each of the three time points examined (data not shown), remained undetectable in the mammary glands of ACI and

Ngày tải lên: 05/11/2020, 05:43

... tetrodotoxin and saxitoxin binding site of the Na+ channel Biophys J 1994; 66:1–13 [182] Penzotti JL, Fozzard HA, Lipkind GM, Dudley SC Differences in saxitoxin and tetrodotoxin binding revealed ... (http://creativecommons.org/licenses/by-nc-nd/3.0/) Introduction Heartbeats, thoughts, and sensations of pleasure and pain begin with the seemingly simple act of the opening of an ion-selective hole in a cell membrane that allows an inward ... prototypes to inform our understanding of eukaryotic NaVs or CaVs in which the SFs are necessarily heteromeric? Long-standing ideas originating in careful biophysical studies of eukaryotic NaVs and CaVs

Ngày tải lên: 02/11/2022, 08:55

... treatment induced a marked increase in the size and complexity of the epithelial structures in the mammary glands of ACI rats This response was observed within week of initiation of E2 treatment and ... discernible induction of lobuloalveolar hyperplasia The luminal ectasia was apparent within week of initiation of E2 treatment and remained the predominant feature in the mammary glands of E2 treated ... 6B and 6E) Mmp7 was undetectable in mammary glands of control ACI and BN rats at each of the three time points examined (data not shown), remained undetectable in the mammary glands of ACI and

Ngày tải lên: 02/11/2022, 09:03

... 2× washing: 30% ethanol) or SGL (safranine CI 50240, pyoctanin blue CI 42535, acid green CI 42095; staining I: safranine, 60 min; washing: H2O, min; staining II: pyoctanin blue, min; washing: H2O, ... understanding of mutations in flower morphology in this crop, an initial cloning of two MADS-box genes was realized in addition to preliminary expression analyses The genome size was determined in ... uncertain, whether stamen development is been initiated or whether the initiation of primordia is inhibited The determination of the flower organ identity and the understanding of the development of

Ngày tải lên: 12/08/2014, 03:21

... expression of tight junction proteins claudin-5, ZO-1, and ZO-2 [112]. Inter- estingly, an increase of active STAT1 and a reduction of claudin-5 were also found in microvessels of brain speci- ... (STAT)-1 and the release of interleukin (IL)-6 and IL-8 [111]. The eukaryotic interleukins and the viral gp120 promoted, in an in vitro BBB model, the attachment and transmigration of monocytes; and ... modified in brains of patients with HIV encephalitis [71,84], and loss of occludin and claudin-5 correlates with areas of mono- cytes infiltration [85]. Such modifications of molecules involved in

Ngày tải lên: 12/08/2014, 23:23

... binding sites upstream of the NF-KB binding site are essential for the efficient transcription in monocytes and macrophages. In addition to NF-KB and Sp1 binding, NF-IL6 and/ or USF protein binding ... with an increase in anti-apoptotic Bcl-2 and Bcl-XL proteins and a decrease of pro-apoptotic Bax and Bad proteins [139]. The role in apoptosis of viral proteins is often dual The protein Nef is ... Page 5 of 16 via the P38-MAPK pathway and is involved in the reacti- vation of latently infected macrophages [91]. The zinc-finger protein OKT18, which is produced during HIV-1 infection of macrophages,

Ngày tải lên: 12/08/2014, 23:23

... resurgence of interest in the clinical use of inert gases. In the present paper we review the use of inert gases as anesthetics and neuroprotectants, with particular attention to the clinical use of ... 2a). Based on protein crystallographic data, the binding of glycine is proposed to result in domain closure of the NMDA receptor leading to channel opening, and competitive inhibitors are suggested ... neuroprotective in in vitro and in vivo brain injury models [40]. Following the discovery that xenon inhibits NMDA receptors, it was shown that xenon could protect neuronal cell cultures against injury induced

Ngày tải lên: 13/08/2014, 20:22

... far [4,10]. In France, the very important development of artificial insemination (AI) since the end of the 1980’s [12] hasresulted in an intensification of the control programmes, andin a drastic ... thepresence of a very thin p-terminal green band on the der(5) chromosome, demonstrating the reciprocity of the exchange, and allowed an accurate localization of the breakpoint on the p-terminal extremity ... as a result of the banding techniques. Chromosome-specific painting probes were produced using DOP-PCR amplification [31] of flow sorted L52 swine chromosomes [29,33]. Fluorescence in situ hybridization

Ngày tải lên: 14/08/2014, 13:21

... other hand, three distinct binding profiles were identified in the collected many-to-one dataset: similar, intersecting and independent. For the similar binding profile, the distinct MoRFs interact ... List of Figures xii List of Abbreviations xiv Chapter 1: Introduction 1.1. Intrinsic Protein Disorder and Protein Functions 1 1.2. Intrinsic Protein Disorder in Protein-Protein Interactions ... Splicing and Posttranslational Modifications in One-to-Many Binding 56 3.2. Many-to-One Binding 59 3.2.1. Peptide-Protein Interactions and Protein-Protein Interactions 61 3.2.2. Binding

Ngày tải lên: 24/08/2014, 09:56

... apoptosis and lung damage in guinea pigs in vivo Effect of N-acetyl cysteine (NAC) on CS-induced protein oxidation in vitro and apoptosis and lung damage in guinea pigs in vivo A, CS-induced protein ... SD; * indicates p < 0.05 and ** indicates p < 0.001 with respect to sham controls C, Colocalization of TUNEL and DAPI staining in the nuclei of lungs of guinea pig fed mg vitamin C/day and exposed ... exposure, intratracheal instillation of p-BSQ in the lungs of vitamin C-restricted guinea pigs also produced inflammation as evidenced by marked increase in the number of neutrophils in BALF In separate...

Ngày tải lên: 11/08/2014, 08:22

... domain of Lrp5/6 contains Axin2 binding sites (Mao et al., 2001) Thus, binding of Axin might be the trigger for inactivation of the phosphorylation of β-catenin The binding sites are five reiterated ... rerio), to gain better understanding of the cellular and molecular processes involved in skeletal development To examine the role of osteoblasts in development of the vertebral column, I created ... great care of our fish I would also like to extend my gratitude to the Republic of Singapore and its decision making bodies for creating and maintaining this wonderful country in the heart of Southeast...

Ngày tải lên: 10/09/2015, 08:43

... embryologist for testing ideas The main ways of interfering with the embryo include changing external physical or chemical factors and examining the intrinsic potential of the embryo and its constituent ... apical ends of cells in the invaginating plate He did find sparse bands of such filaments which probably contained actin in these cells, but they were indistinguishable from those elsewhere in the ... cells (Ettensohn, 1984) initially participating in invagination lessen their adhesions to one another and soflattenand increase their surface area This increase will, in principle, force the epithelium...

Ngày tải lên: 05/03/2014, 11:21

... protein serine ⁄ threonine protein kinase; MEK, MAPK serine ⁄ threonine protein kinase; MLCK, myosin light chain kinase (serine ⁄ threonine protein kinase); MLCPase, myosin light chain phosphatase; ... (activation) of the signaling pathway, and barred lines indicate the negative direction (inhibition) of the signaling pathway Full lines indicate interactions that are known to be direct, and broken lines ... kinase 1; PI3K, phosphatidylinositol 3-kinase; Pim-1, Pim serine ⁄ threonine protein kinase-1; PKA, cAMP-dependent protein serine ⁄ threonine kinase A; PKC, calcium-dependent serine ⁄ threonine...

Ngày tải lên: 22/03/2014, 15:21