Role of calpain and cofilin in apoptosis regulation

... blocking cofilin translocation Figure 5.4.3 Cofilin S3D blocks translocation of endogenous cofilin Figure 5.5 Mitochondrial-localised cofilin induces apoptosis Figure 5.6.1 Cofilin1 5-166, cofilin1 5-30/106-166 ... Silencing of cofilin expression using cofilin siRNA Figure 5.2.2 Lack of cytochrome c release and apoptotic morphology in cofilin knockdown cells Figure...

Ngày tải lên: 17/09/2015, 17:19

... of the TRIP- Br proteins 17 2.3 The functional properties of the TRIP- Br proteins 18 2.3.1 The unique ability to interact with the PHD zinc 18 finger and/ or the bromodomain iv 2.3.2 The TRIP- Br ... potentials of the TRIP- Br proteins 2.4 The TRIP- Br proteins: a novel class of cell cycle regulator 21 2.4.1 The mammalian cell cycle...

Ngày tải lên: 16/09/2015, 17:12

... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino ... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the m...

Ngày tải lên: 19/02/2014, 13:20

... difficulties in understanding the functional role of receptor cleavage and shedding Some mutations or small deletions of individual or groups of amino acids did not prevent receptor cleavage, due ... a role for the extracellular domain in the stabilization of an inactive form of the unliganded receptor [29] Indeed, only cleavage in the E3 domain of the rec...

Ngày tải lên: 21/02/2014, 00:20

... proteins (ACPs) [14,15] The genes dptE and dptF are localized immediately upstream of the NRPSs of A21987C The resulting proteins DptE and DptF were predicted to be involved in the lipidation reaction ... the initiation module of daptomycin That DptE and DptF are involved in the lipidation process of daptomycin was first shown by Miao et al [...

Ngày tải lên: 07/03/2014, 04:20

... Sherraden, and Julia Stevens for comments CENTER FOR SOCIAL DEVELOPMENT WASHINGTON UNIVERSITY IN ST LOUIS i REDUCING WILT The Role of Savings and Wealth in Reducing ―Wilt‖ between Expectations and College ... Destin, 2009) Charles, Roscigno, and Torres (2007) is the only study of the seven to examine the relationship between parent school savings...

Ngày tải lên: 15/03/2014, 10:20

... value of 24.2 1.87 kJặmol)1 Effect of calcium on pfLamA mutants in 7.9 GdmCl and in native conditions M The addition of 40 mm CaCl2 to calcium-depleted samples of D287A and E53A in 7.9 m GdmCl ... and the uorescence properties (data not shown), Role of Glu53 and Asp287 in the stability in 7.9 M GdmCl Fig Interaction of calcium with pfLamA...

Ngày tải lên: 30/03/2014, 04:20

... that both ADAM10 and TACE are involved in the shedding of APP, neither ADAM is involved in the shedding of ACE Furthermore we show that APMA can distinguish between the shedding of ACE and APP ... would appear that ADAM10 and TACE are not critically involved in the shedding of ACE APMA has been reported to induce the shedding of a number of pro...

Ngày tải lên: 30/03/2014, 14:20

... level in Zambia served in the capacity of district managers of health programmes The finding that the nurses in Sudan were less involved in planning of activities (15.2% in polio and in measles) ... in AFP surveillance On the other hand, in Zambia, nurses and midwives were involved in the full range of functions for SIAs and AFP surveillanc...

Ngày tải lên: 18/06/2014, 17:20

... at the start of night prolongation, or 12 wk, an important role in the possibility of the buds to attain a deeper stage of dormancy Only the 12 wk old plants of northern origin had no flushing ... the chilling requirement to break winter dormancy in Scots pine has been stressed (e.g., Wareing, 1951; Vegis, 1965; Sarvas, 1974) In the following,I will use the w...

Ngày tải lên: 09/08/2014, 02:21

... Hyperactivation of β-catenin, caused by mutations of β-catenin, APC, and axin in lung epithelium induces lung tumors [102] β-catenin is overexpressed and activated in many lung cancer cells Wnt/ β-catenin ... W, Yamin M, Noda M, et al.: Pleiotrophin signals increased tyrosine phosphorylation of beta betacatenin through inactivation of the intrinsic catalytic acti...

Ngày tải lên: 12/08/2014, 11:22

... Mukai R, Yoshikawa Y: In vitro immortalization of Old World monkey T lymphocytes with Herpesvirus saimiri: its susceptibility to infection with simian immunodeficiency viruses Virology 1996, 218:382-8 ... response determined by a yield reduction assay NAb response determined by a yield reduction assay Before challenge (indicated by a black arrow) nAbs were measured in monkeys...

Ngày tải lên: 12/08/2014, 23:21

... Figure of intra-portal injection of (a) ATP and (b) adenosine on changes in hepatic arterial flow (∆ HAF) in vivo The effect The effect of intra-portal injection of (a) ATP and (b) adenosine on ... portal vein and the inferior vena cava of the in vivo rabbit model Figure Diagram of silastic H-shaped prosthesis inserted into the portal vein and...

Ngày tải lên: 13/08/2014, 13:20

... the need in understanding the role and interaction of PLD with other TNFα signaling mediators PKC The role of PKC (Protein Kinase C) in TNFα induced signaling and responses in a variety of cells ... inflammatory role of PLD in TNFα -induced signaling and responses Recent studies were more conclusive and detailed about the role of PLD in...

Ngày tải lên: 11/09/2015, 16:06