Role of c jun in the regulation of tumor suppressor p53 homo

Role of c jun in the regulation of tumor suppressor p53 homologue, p73

... Hypopharyngealcarcinomas Oesophageal cancer Gastric cancer Colorectal cancer Bladder cancer Prostate cancer Renal cancer Cholanglocarcinoma Hepatocellular carcinma Leukemia &lymphoma Breast cancer Ovarian ... on c- Jun 28 2.11 The Regulation of c- Jun 29 2.12 The stability of c- Jun protein 30 2.13 The relationship between p53 and c- Jun 30 VI 3.1 Hypothesis: The...

Ngày tải lên : 16/09/2015, 15:55

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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx

... of glycogen in the intact liver in vivo Second, during infusion of [1-1 3C ]glucose, label incorporation was observed not only into the C1 of glycogen but also the C6 , which can only occur by label ... a mechanism can lead to increases in labeling of glycogen C6 even in the presence of decreased activity of the indirect pathway, provided that the increas...

Ngày tải lên : 17/03/2014, 17:20

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ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU80 C-TERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU

... unwavering support of my goals iv ABSTRACT Sara M McNeil ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU8 0 CTERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU DNA double strand breaks ... than that of the 16 kDa Ku8 0CTR band and the band intensity generated from Ku7 0 and Ku8 0 C antibodies, indicating a small per...

Ngày tải lên : 24/08/2014, 11:02

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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

... conﬁrmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell cycle ... proteins with the promoter E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85] Another E2F site distal to the E2F ⁄ CDE acts...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O2 Culture medium was replaced every other day inside the chamber For miRNA transfection, ... were treated as described in (A) Total RNA was prepared at the indicated times and subjected to quantitative real-time PCR analysis The data shown are mean value ± standard err...

Ngày tải lên : 18/02/2014, 08:20

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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx

... in Role of helix and C-termini in bradykinin receptors receptor signaling because: (a) interruption of the amphipathic structure of B1wt helix in B1wt and B1KB2 through the presence of a serine ... TSIfiAAA N3 38* B1wt B1RB2 B1NB2 B1CB2 B1KB2 B1KB2 ⁄ SfiV B1KB2 ⁄ QGVfiKQ B1KB2 ⁄ VCfiCV B1YB2 B1V323S 10400 5020 52 98 383 2 625 127 511 1701 182 3 17 58 2142 1 786...

Ngày tải lên : 07/03/2014, 16:20

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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

... raise the possibility that GSK3 may help to coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin ... Effects of insulin, Li and SB-415286 on signalling elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and...

Ngày tải lên : 08/03/2014, 08:20

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Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx

... m wt )11 9/ +17 8 )11 9/ +14 3 )22/ +17 8 )22/+4 10 0 73 91 23 21 ± 10 ± 3.4 ± 2.6 10 0 13 3 10 0 15 0 ± ± ± ± 12 10 10 m ± ± ± ± 30 20 20 70 70 28 ± ± ± ± 20 not examined which sequences in the )11 8/)35 ... site(s) (A) Eﬀect of point mutations in Ets and Sp1 motifs on PS1 promoter activity The positions of Ets (d) and Sp1 (h) motifs in the )11 9/ +17 8 reg...

Ngày tải lên : 16/03/2014, 18:20

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AN INCREASING ROLE FOR COMPETITION IN THE REGULATION OF BANKS doc

... distinguish two mechanisms by which the failure of one bank could lead to the failure of other banks or other non-bank firms: (a) the failure of one bank leading to a decline in the value of the ... writes: The financial sector was deregulated and … with the economic liberalization, new banks, financial institutions, leasing companies, housing finance, investment com...

Ngày tải lên : 29/03/2014, 08:20

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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc

... Colosia AD, Donahue JP, Lin YZ, Hawiger J: Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization ... stress-activated protein kinases, also called cJun NH2-terminal kinases (JNKs); and the p38 MAPKs [13] The JNK pathway is of interest because of its capacity to phosphorylat...

Ngày tải lên : 09/08/2014, 07:20

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báo cáo khoa học: " The transcription factor PHR1 plays a key role in the regulation of sulfate shoot-to-root flux upon phosphate starvation in Arabidopsis" potx

... Cite this article as: Rouached et al.: The transcription factor PHR1 plays a key role in the regulation of sulfate shoot-to-root flux upon phosphate starvation in Arabidopsis BMC Plant Biology 2011 ... regulation was reflected in a decrease in the shoot-to-root sulfate transfer in the phr1 mutant relative Page of 10 to WT Interesting...

Ngày tải lên : 11/08/2014, 11:21

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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf

... into the lungs and to increased pulmonary proinflammatory cytokine expression [7] However, the initial events induced by hyperoxia, thereby leading to acute inflammatory lung injury, remain incompletely ... [26–37] In a murine hyperoxia model, the effects of lisofylline on the activation of NF-κB and CREB, on the expression of proinflammatory cytokines in the lungs...

Ngày tải lên : 12/08/2014, 19:21

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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx

... required for the expression of many cytokines involved in the pathogenesis of acute lung injury [26–35] In acute lung injury caused by infection of bacteria, cytokine receptors HIF-1 consists of two ... function play a central role in initiating the innate immune system and in activating NF-κB Anti-inflammatory cytokines have the ability to suppress inflammat...

Ngày tải lên : 12/08/2014, 19:21

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The role of the n terminal extension domain of vamp4 in the regulation of its recycling to the TRANS GOLGI network

... mammalian SNAREs Name Syntaxin Syntaxin Syntaxin Syntaxin Syntaxin Syntaxin Syntaxin Syntaxin Syntaxin 10 Syntaxin 11 Syntaxin 13 Syntaxin 16 Syntaxin 17 Syntaxin 18 Syntaxin 19 Syntaxin 20 Syntaxin 21 ... preceding N- terminal domain Habc with preceding N- terminal domain Habc with preceding N- terminal domain Habc with preceding N- terminal domain Habc with preceding N-...

Ngày tải lên : 11/09/2015, 09:02

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The role of TRIP br proteins in the regulation of mammalian gene transcription and cell cycle progression

... of the TRIP- Br proteins 17 2.3 The functional properties of the TRIP- Br proteins 18 2.3.1 The unique ability to interact with the PHD zinc 18 finger and/ or the bromodomain iv 2.3.2 The TRIP- Br ... potentials of the TRIP- Br proteins 2.4 The TRIP- Br proteins: a novel class of cell cycle regulator 21 2.4.1 The mammalian cell cycle...

Ngày tải lên : 16/09/2015, 17:12

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