Study of the associated proteins of STAT3 and characterization of their functions roles of GRIM 19 and PIN1 in the regulation of STAT3 activity

... STUDY OF THE ASSOCIATED PROTEINS OF STAT3 AND CHARACTERIZATION OF THEIR FUNCTIONS: ROLES OF GRIM- 19 AND PIN1 IN THE REGULATION OF STAT3 ACTIVITY LUFEI CHENGCHEN B Sc (Hons), NUS A THESIS ... fold of human Pin1 37 Figure 3.1 Interaction of Stat3 and GRIM- 19 71 Figure 3.2 Association of endogenous Stat3 and GRIM- 19 75 Figure...

Ngày tải lên: 15/09/2015, 17:10

... and that vincristine inhibits the high affinity DNP-SG transport in the presence but not in the absence of GSH [12,45,46] Thus the effect of vincristine on the cGMP uptake was also tested in the ... these and cGMP block low affinity [3H]DNPSG transport in human erythrocytes and so the low affinity transport of DNP-SG and the transport of c...

Ngày tải lên: 23/03/2014, 21:20

... to identify the intermediates in the various T roseopersicina mutants are in progress In summary, HupK is selectively involved in the biosynthesis of the various [NiFe] hydrogenases In contrast, ... HupK protein Thirty one amino acid residues in the truncated HupK originated from the N-terminus, 37 aa from the C-terminus of the protein and 13 aa c...

Ngày tải lên: 31/03/2014, 01:20

... retinoic acid (RA) treatments on GnRH II promoter activity To investigate the in vivo effect of RARa and RXR on the transcriptional regulation of the hGnRH II gene, the expression vector of human ... on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of RARa and RXRa with their ligands, ATRA and 9-...

Ngày tải lên: 16/03/2014, 10:20

... 5'-TGTTTGGAGACTGTGTACAAGGCG-3', hTERT sense, 5'-TGTTTCTGGATTTGCAGGTG-3' and antisense, 5'-GTTCTTGGCTTTCAGGATGG-3', Pot1 sense, 5'TGGGTATTGTACCCCTCCAA-3' and antisense, 5'-GATGAAGCATTCCAACCACGG-3' TRF1 ... Collectively, these results validate a balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and POT1 in normal, a...

Ngày tải lên: 13/08/2014, 09:21

... blocking cofilin translocation Figure 5.4.3 Cofilin S3D blocks translocation of endogenous cofilin Figure 5.5 Mitochondrial-localised cofilin induces apoptosis Figure 5.6.1 Cofilin1 5-166, cofilin1 5-30/106-166 ... Silencing of cofilin expression using cofilin siRNA Figure 5.2.2 Lack of cytochrome c release and apoptotic morphology in cofilin knockdown cells Figure...

Ngày tải lên: 17/09/2015, 17:19

... (dashed line) initial AOC levels with Cumulative survival of patients with Alzheimer's disease with low (solid line) and high (dashed line) initial AOC levels Low and high AOC levels were defined ... and of its capacity to cope with inflammatory and oxidative insults The lower levels of peripheral AOC observed in AD patients is also consistent with the finding of l...

Ngày tải lên: 19/06/2014, 22:20

... comparable between these two groups In the subgroup of patients with peritonitis with septic shock, biliary origin was independently associated with increased mortality Yeast in peritoneal fluid of postoperative ... Intra-peritoneal yeasts and Enterococci were associated with septic shock in the subgroup of patients with community-acquired peritonitis Yeas...

Ngày tải lên: 13/08/2014, 16:21

... history of diabetes and higher body mass indexes During the five years of follow-up, 1 02 (15 .2% ) patients in the normoglycaemia group and 66 (18.3%) patients in the hyperglycaemia group died There ... inclusion in the study We excluded 21 1 patients who refused to participate in the study, 20 3 patients due to terminal illness, and another 29...

Ngày tải lên: 25/10/2012, 10:02

... conformational ¯exibility We not consider the rheomorphic state of a Caseins, synucleins and tau as rheomorphic proteins The ROA data clearly show the caseins, synucleins and tau to have similar ... caseins, synucleins and tau (Eur J Biochem 269) 155 CONCLUSIONS This study has shown that the casein milk proteins, the brain proteins synuclein and...

Ngày tải lên: 21/02/2014, 15:20

... Gornik et al Critical Care 20 10, 14:444 http://ccforum.com/content/14/5/444 Page of 22 07 patients admitted to medical ICU 385 with a history of DM, IFG or IGT 1 822 27 4 died in hospital 1548 screened ... 21 1 refused participation - 20 3 terminally ill - 29 receiving corticosteroids 669 436 NORMOGLYCAEMIA HYPERGLYCAEMIA 76 excluded: - newly diagnosed DM, IGT or IFG...

Ngày tải lên: 13/08/2014, 21:21

... clinical evaluation of patients, samples and data collection PS participated in the statistical analysis NGQ, IS and EHR did genotyping CRG conceived the study, analyzed and interpreted data, and wrote ... overrepresented among patients who died at 28 or 90 days, and they also predisposed to MODS and ARDS respectively Likewise, 6A was associated with ARDS, and 1A was...

Ngày tải lên: 14/08/2014, 07:21

... out by the Dcp1- Dcp2 holoenzyme Dcp2 is a Nudix pyrophosphatase and Dcp1 stimulates the activity of Dcp2 The crystal structures of yeast Dcp1 and Dcp2 proteins are presented in this study The structure ... function and regulation of the decapping proteins Dcp1 and Dcp2 Yet several questions still remain open regarding the decapping com...

Ngày tải lên: 14/09/2015, 12:28

... THE STUDY OF INTERACTIONS OF TRANSMEMBRANE RECEPTORS AND INTRACELLULAR SIGNALING PROTEINS IN LIVE CELLS BY FLUORESCENCE CORRELATION AND CROSS -CORRELATION SPECTROSCOPY LIU PING (M.Sc), CAS A THESIS ... C-terminus domain, to expose binding sites for Src-homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing...

Ngày tải lên: 14/09/2015, 14:25

... process of drug discovery - VI - Computational study of therapeutic targets and ADME- associated proteins and application in drug design List of Tables LIST OF TABLES Table 1-1: A brief history of ... pharmacogenetic prediction of drug responses 159 - VII - Computational study of therapeutic targets and ADME- associated proteins and...

Ngày tải lên: 15/09/2015, 22:19