Data mining techniques in gene expression data analysis

... expression analysis, supervised data mining methods include class association rule mining and classification while unsupervised data mining methods mainly refer to the various clustering methods ... biological information from the huge and fast-growing gene expression data Essentially, data mining methods can be divided into two big categories: supervised and unsupervise...

Ngày tải lên: 15/09/2015, 17:09

... Genomic Datasets 27 2.5 Gene Expression Data for Strain Improvement 30 Overview of Proposed Data- mining Framework for Strain Improvement 32 PCA Based Methodology for ... Novel data- mining methods suitable for gene expression data mining are proposed and validated using artificial and real expression datasets In the following sections, gene expression...

Ngày tải lên: 11/09/2015, 09:01

... COMPUTATIONAL ANALYSIS OF SEXUAL DIMORPHISM IN GENE EXPRESSION UNDER TOXICO- PATHOLOGICAL STATES ZHANG XUN (B.Sc & M.Sc., Lanzhou University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF ... review of sex-dimorphic gene expression in animals under both normal physiology and toxicopathological states The current understanding of hormonal and genetic c...

Ngày tải lên: 09/09/2015, 10:18

... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain The DNA-binding domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... domain involved in protein–protein interactions FYRC and FYRN domains are involved in heterodimerization between MLLN and MLLC terminal fragments High-mobility group (HMG) domains ar...

Ngày tải lên: 16/02/2014, 14:20

... 107.7 interferon, alpha-inducible protein 27 (ISG12, P27) 1.9 interferon -induced protein 35 5.0 Interferon -induced protein 44, p44 8.4 interferon -induced protein 44-like 2.2 interferon induced ... relapsed by the end of treatment Changes in Global Gene Expression Gene expression in PBMC changed dramatically and rapidly during PEG-interferon- α2b (PegIntron™) /ribaviri...

Ngày tải lên: 18/06/2014, 15:20

... further investigate the relationship between genetic variation in gene expression and phenotypic variation, we measured genome-wide mRNA transcript levels in nine strains of Saccharomyces cerevisiae ... differences in transcript abundance both within and between closely related species [4-12] In some instances, genetic variation in gene expression has been as...

Ngày tải lên: 09/08/2014, 20:20

... of gene Birnbaum et al [5] used binary coding, principal component analysis and k-means clustering to find dominant expression patterns among the 5,712 differentially expressed genes (defined ... as coordinates, resulting in five points in a multidimensional space The Euclidian geometric distance between these points was calculated To obtain the clustering, the points closest in spa...

Ngày tải lên: 09/08/2014, 20:20

... http://www.biomedcentral.com/1471-2229/11/76 Page of 10 Table The 20 most abundant ESTs in the tobacco leaf trichome library with gene annotation of their closest hit identified by Blastx No of ESTs Gene ID Gene annotation of closest ... differentially expressed genes between trichomes and leaves were compared A total of 63.7% of highly expressed genes and 70.6% of low...

Ngày tải lên: 11/08/2014, 11:20

... e-CCC -Biclustering: Finding and reporting all maximal eCCC-Biclusters in polynomial time This section presents e-CCC -Biclustering, a polynomial time biclustering algorithm for finding and reporting ... Related work on biclustering algorithms for time series gene expression data Supplementary material describing related work on biclustering algorithms for...

Ngày tải lên: 12/08/2014, 17:20

... that the initiating pathway determines a distinctive expression phenotype in tumors In addition, using proteins as markers of cell phenotypes, we showed that initiating oncogenes determine the developmental ... discussion Mammary tumors in MMTV-Wnt-1 transgenic mice have an expression profile distinct from that seen in mammary tumors induced by MMTV-Neu Compari...

Ngày tải lên: 14/08/2014, 14:22

... microarray technology continues to be a mainstay of biologic discovery However, the ability to measure gene expression signatures of interest with great rapidity and flexibility, and at very high ... performed with LMF in our laboratory also delivered impressive accuracies (30 -gene androgen signature, 642 wells: 98.8% accuracy; 11 -gene sarcoma signature, 766 wells: 99.6% accuracy; 2...

Ngày tải lên: 14/08/2014, 16:21

... repositioning Nuclear lamina which includes lamin and lamin binding proteins mediates chromosomal positioning (125, 126) Along with chromosome positioning, gene clustering has also been considered ... by geometrical cues and how it correlates with chromatin compaction and gene expression The critical molecular intermediates involved in the geometry regulated chromatin compa...

Ngày tải lên: 10/09/2015, 09:04

... of N data points to be clustered The local maximum of a data point i is the data point whose magnitude is the maximum among all the data points within a certain distance from the data point i ... the clustering results of different methods The letters L, H, K, and S stand for the LMC method, the hierarchic clustering method, the K-mean clustering...

Ngày tải lên: 23/06/2014, 01:20

... Tillett et al.: Identification of tissue-specific, abiotic stress-responsive gene expression patterns in wine grape (Vitis vinifera L.) based on curation and mining of large-scale EST data sets BMC ... Lund S: Generation of ESTs in Vitis vinifera wine grape (Cabernet Sauvignon) and table grape (Muscat Hamburg) and discovery of ne...

Ngày tải lên: 11/08/2014, 11:20

... the localized high-frequency details of the expression signal When the wavelet is fully diluted, the length of the wavelet is more comparable to the length of the gene expression signal and therefore ... therefore it extracts the low frequency trends of the signal In order to overcome the issue in temporal gene expression data analysis we take an approach usi...

Ngày tải lên: 22/06/2014, 19:20