Paclitaxel loaded nanoparticles of biodegradable polymers for cancer chemotherapy

... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CONTROLLED AND TARGETED DELIVERY OF PROTEIN DRUGS SMALL AND MOLECULE DRUGS BY LEE SIE HUEY (B.Sc (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF ... backbone of PLA and PLGA to form PLA-TPGS and PLGA-TPGS block copolymers These block copolymers are an example of amphiphiles Their uses as different carriers for delivery of protein and anticancer ... Peptide /protein drug delivery 15 2.2.1 Structural aspect of protein 15 2.2.2 Challenges in peptide /protein drug delivery 17 2.2.3 Approaches for delivery of peptide /protein drugs...

... Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves as an impermeable wall to prevent the entry of agents from outside of the brain ... Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS TO OVERCOME THE BLOOD BRAIN BARRIER 1.3 NANOPARTICLES ... polymers to deliver drugs across the blood brain barrier and the surface coating plays key roles in determining the extent of the particles to cross the BBB To further investigate the potential for the...

... some suggestions for future directions of this research are given Chapter Literature Review 2.1 Nanoparticles of Biodegradable Polymers 2.1.1 Basic information of Biodegradable Polymers Recently, ... of iron loading (% w/w) was calculated as the ratio of the mass of iron (mg) that can be detected using ICP analysis to the sum of the mass of iron (mg) and the mass of polymer (mg) 3.3.7 Magnetic ... are termed superparamagnetic iron oxides (SPIOs) where nanoparticles have a size greater than 50 nm (coating included) and the second type termed ultrasmall superparamagnetic iron oxides (USPIOs)...

... of the nanoparticle formulation (3) The advantages in cancer cell viability of the 5% DMABmodified PLGA-TPGS nanoparticles (CNP) >the unmodified PLGA-TPGS nanoparticles (BNP) >the Taxotere® formulation ... [31,32] The cellular uptake of coumarin-6-loaded 5% DMAB-modified PLGA nanoparticles (ANP), unmodified PLGA-TPGS nanoparticles (BNP) and 5% DMAB-modified PLGA-TPGS nanoparticles (CNP) was thus ... PLGA-TPGS nanoparticles (BNP) Such advantages of the nanoparticle formulations can be contributed to the effects of TPGS and DMAB component of the nanoparticles in enhancing cellular uptake of...

... University Shijo-cho 840 Kashihara-shi Nara 63 4-8 521 Japan List of Contributors Jay Prakash Jain National Institute of Pharmaceutical Education and Research (NIPER) Department of Pharmaceutics ... Department of Polymer Science and Engineering Daejeon 30 5-7 64 South Korea Masaji Watanabe Okayama University Graduate School of Environmental Science 1-1 , Naka 3-chome Tsushima, Okayama 70 0-8 530 Japan ... relevance of biodegradable dendrimers and dendritic polymers to the medical field Methods: Van der Zee gives a description of the methods used to quantify biodegradability and the implications of biodegradability...

... reality, a reasonably large sample size with a compatible control is a must for examining such an alternative therapy For any scientific study of a new therapy or treatment, a large amount of time and ... Conf for Acad Exch of Med Qigong Beijing, China 1993:128 Sun QZ, Zhao L Clinical observation of Qigong as a therapeutic aid for advanced cancer patients Proc of the 1st World Conf for Acad Exah of ... Therefore, an effective non-pharmacological therapy for cancer with less cost and no side effects could have a major impact on cancer treatment Qigong therapy from TCM shows promise in treating cancer...

... "vinyl" siding used on houses is made of poly(vinyl chloride) Inside the house, PVC is used to make linoleum for the floor In the seventies, PVC was often used to make vinyl car tops PVC is useful ... it's a polystyrene chain with chains of polybutadiene growing out of it Food Packaging Materials These rubbery chains hanging off of the backbone chain some good things for polystyrene Polybutadiene ... UHMWPE can be used to make fibers which are so strong they replaced Kevlar for use in bullet proof vests Large sheets of it can be used instead of ice for skating rinks Food Packaging Materials...

... Initially, derivatization of small diameter CNT (HipCO) was achieved by electrochemical reduction of substituted aryl 11 10 Chemical Reviews, 2006, Vol 10 6, No Figure 10 Electrochemical functionalization ... fabricated films consisting of alternating layers of anionic PSS-grafted Chemistry of Carbon Nanotubes Chemical Reviews, 2006, Vol 10 6, No 11 13 Figure 15 Grafting of polystyrene chains by anionic ... 4-alkylanilines could also give soluble material ,14 0 whereas the presence of the long alkyl 11 14 Chemical Reviews, 2006, Vol 10 6, No Figure 17 Direct thermal mixing of nanotubes and long chain amines chain...