Modulation of drug transport by citrus fruit juices

... MODULATION OF DRUG TRANSPORT BY CITRUS FRUIT JUICES LIM SIOK LAM (B.Sc (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF PHARMACY NATIONAL UNIVERSITY OF ... 1.2.2.3 Lime and lemon juices 37 1.2.2.4 Other citrus fruit juices 37 1.3 Statement of purpose 38 Chapter Effects of citrus fruit juices on cytotoxicity and dr...

Ngày tải lên: 14/09/2015, 18:34

... governed by the concentration gradient of the permeant across the luminal and basal membranes The rate of transport is often directly proportional to the gradient Transport of solute by passive ... project was that spices consumed as food supplements could affect oral drug bioavailability by interfering with intestinal drug transport To prove our hypothesis, a series...

Ngày tải lên: 14/09/2015, 12:37

... Sterol homeostasis modulation by Ste20p and Cla4p M Lin et al Introduction The Rho-type GTPase Cdc42p plays a crucial role in the establishment and maintenance of cell polarity [1,2] In the ... that sterol 7254 biosynthesis may increase during formation of a mating projection [28] Furthermore, homologues of oxysterolbinding proteins, a family of proteins...

Ngày tải lên: 18/02/2014, 13:20

... suggest that the dual modulation of prothrombin activation by plactin leads to an antithrombotic state under physiological coagulating conditions Dual modulation of prothrombin activation 1st ... the N-terminus of its B-chain [19] The sequential mechanism leading to enhancement of scu-PA activation is shown in Fig 3F Dual modulation of prothrombin...

Ngày tải lên: 07/03/2014, 00:20

... 1203 Nickel ions and Euphorbia peroxidase F Pintus et al Table Kinetic parameters of ELP native enzyme in the presence of different concentrations of Ca2+ and in the concomitant presence of 30 ... (B) Euphorbia peroxidase in the presence of 30 mM Ni2+ before and after addition of an equimolar amount of H2O2 Arrows indicate the disappearance of compound I after addi...

Ngày tải lên: 30/03/2014, 04:20

... mechanism of immune escape, and second, to evaluate the potential beneficial systemic effect of SPPV on the host immune system Early immune response to SPPV at the site of inoculation provides ... response by SPPV is not dependent on virus infectivity Later and systemically, the virus protects the host from any fatal consequences of the suppression o...

Ngày tải lên: 18/06/2014, 22:20

... changes in walking speed in response to an OF of continually changing speed (Experiment 1) were examined In the second, the voluntary or intentional changes in walking speed in response to OFs at ... subjects Modulation (plain lines) withhealthy (B) and (A) and walking Modulation of gait speed (dotted lines) as a function of optic flow speed (plain li...

Ngày tải lên: 19/06/2014, 10:20

... mechanism of immune escape, and second, to evaluate the potential beneficial systemic effect of SPPV on the host immune system Early immune response to SPPV at the site of inoculation provides ... response by SPPV is not dependent on virus infectivity Later and systemically, the virus protects the host from any fatal consequences of the suppression o...

Ngày tải lên: 20/06/2014, 04:20

... Takeno M, Saito N, Yokoe T, Kaneko A, Asai T, Sakane T: Modulation by proinflammatory cytokines of Fas/ Fas ligand- mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis ... to FasL -induced cell death, and TNF -α prevented these cells from undergoing FasL -induced cell death in a dose-dependent manner No such inhibitory ef...

Ngày tải lên: 09/08/2014, 01:23

... Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways Journal of Biomedical Science 2011 18:74 Submit your ... MU, Parinandi NL, Tridandapani S, Kutala VK, Kuppusamy P: C-phycocyanin protects against ischemia-reperfusion injury of heart through inv...

Ngày tải lên: 10/08/2014, 10:20

... peptides including LANP, VD and KP in modulating lung inflammation In this report we show that overexpression of VD attenuates airway inflammation in a mouse model of allergic asthma The effects of ... determine airway resistance values and peak values obtained after each MeCh challenge were plotted [16] Modulation of lung inflammation by VD To test the eff...

Ngày tải lên: 12/08/2014, 14:20

... Since apoptosis mediated by Tat partly relies on the interaction of Tat with tubulin [14-17], we hypothesized that zinc binding might play a role in the modulation by Tat of the microtubule dynamics ... 5:62 Consequently, holo -Tat likely constitutes the active form of Tat in the cell cytoplasm By altering the microtubule dynamics, holo -Tat may t...

Ngày tải lên: 13/08/2014, 05:21

... quantum thermal transport using the unified language of consistent quantum theory The study in this thesis may further our understanding on the statistical properties of quantum thermal transport ... The study of energy transport by consistent quantum histories LI HUANAN (B.Sc., Sichuan University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF P...

Ngày tải lên: 10/09/2015, 09:25

... the anesthetics benzyl alcohol, propofol, chloroform and diethyl ether reversed the resistance by acceleration of the passive transport of the drug or dye across the plasma membrane At these concentrations, ... concentrations, the anesthetics further enhanced the rate of passive drug permeation and interfered with the active export of the drug...

Ngày tải lên: 30/03/2014, 04:20

... 90% of their energy at a wavelength of 253.7 nanometers Exposure of bacteria to UV results in cross-linking of the thymine dimers of the DNA in the organism, preventing repair of injury and reproduction ... is among the main reasons for contamination in fruit juice Washing and brushing fruit before the juicing step is common in juice processing Acco...

Ngày tải lên: 25/10/2013, 21:20