Studies of the anticancer potential of andrographolide in human cancer cells

... the importance of PT in the mitochondrial apoptosis, because in the absence of the hallmarks of PT, including the loss of the inner membrane potential and the rupture of the outer membrane, the ... hypoxia), and they found that the type, strength and kinetics of the target gene profiles depend on the levels of p53 in the cell, the type of in...

Ngày tải lên: 14/09/2015, 14:11

... Nanyang Technological University, Singapore (Silver Best Poster Award) vi THE MECHANISTIC STUDIES OF THE ANTICANCER POTENTIAL OF ARTESUNATE IN HUMAN CANCER CELLS Table of Contents DECLARATION ... ART induced autophagy in human cervical cancer HeLa cells evidenced by the increase of autophagic flux In the search of the mechanisms for ART-induced...

Ngày tải lên: 09/09/2015, 08:16

... design DNAdirected alkylating agents by linking the alkylating pharmacophore to the DNA- affinity molecules (e.g., DNA intercalating agents, DNA minor groove binder) [7,8] In most cases, the DNA- directed ... article as: Chu et al.: Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through...

Ngày tải lên: 09/08/2014, 09:20

... acetylcholine receptor protein in seen in these cell lines Using a specific antibody for the α7 nicotinic acetylcholine receptor (Abcam), membrane protein from the cell lines were assessed by western ... nitrosamine, 4(methylnitrosamino)-1-(3-pyridyl)1-butanone (NNK), is a high affinity agonist for the α7 nicotinic acetylcholine receptor (α7 nAChR) [5] Binding...

Ngày tải lên: 12/08/2014, 18:21

... Upregulation of TRPV4 protein and mRNA across the BCM model 3.1.4 Upregulation of TRPV4 in invasive human breast cancer cell lines and tissues 37 37 42 TRPV4 is a positive regulator of breast cancer metastasis ... roles and modes of actions in breast cancer metastasis remain obscure We hypothesize that TRPV4 is a positive regulator in breast canc...

Ngày tải lên: 02/10/2015, 17:15

... staining of STC-1 in tumor tissues of nude mice STC-1 was detected on the membrane of tumor cells (D) Immunohistochemical staining of PCNA in tumor tissues of nude mice PCNA was detected in the ... Signaling Technology, USA) at 1: 1000, and the anti-btubulin rat monoclonal antibody (Beyotime, China) at 1:1000 VEGF Assay VEGF content in tumor culture supernatants...

Ngày tải lên: 10/08/2014, 05:21

... article as: Niu et al.: Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells Journal of Experimental & Clinical Cancer Research 2011 30:28 ... rapamycin will result in some beneficial modulation of the cancer killing properties of docetaxel in lung cancer cells [20,21] To the best of...

Ngày tải lên: 10/08/2014, 10:21

... EFFECTS OF SULFIDE- CONTAINING COMPOUNDS ON DEVELOPMENT OF ATHEROSCLEROSIS IN HUMAN UNDOTHELIAL CELLS AND HYPERLIPIDEMIC RABBITS WEN YA-DAN Master of Medicine, Soochow University ... Effects of SPRC on ultrastructure of thoracic aorta of NZW rabbits 143 4.4.5 Effects of SPRC on oxidative stress in the NZW rabbits 145 4.4.6 Effects of SP...

Ngày tải lên: 30/09/2015, 06:38

... damaging and telomeretelomerase effects and hence the mechanism of action of TQ in breast cancer cells In addition, it is of interest to investigate the effects of TQ in normal breast epithelial cells ... Black cumin seeds (left) and chemical structure of thymoquinone (right) 23 Figure 10 Growth inhibitory effects of TQ on breast cancer cells 39...

Ngày tải lên: 30/09/2015, 13:41

... response in vivo in C elegans and in vitro in human breast cancer cells Oncogene 2009, 28:2419-2424 12 Maes OC, An J, Sarojini H, Wu HL, Wang E: Changes in MicroRNA Expression Patterns in Human ... sensitivity in A549 lung cancer cells [10] Let-7 family members are down-regulated in lung cancer cells [9] which possibly increases cell growth by increasing KRAS...

Ngày tải lên: 09/08/2014, 09:20

... SCREENING AND EVALUATION OF THE ANTICANCER POTENTIAL OF SCORPION VENOMS AND SNAKE VENOM L- AMINO ACID OXIDASE IN GASTRIC CANCER DING JIAN (B.S.c) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF ... responsible for the anticancer activities of BHV and LAAO The novel findings shed light on the development of anticancer agents from sco...

Ngày tải lên: 09/09/2015, 08:13

... C: Insulin and LiCl prevent down-regulation of cyclin D1 induced by luteolin in HK1 cells Fig 3.7D: Insulin and LiCl abrogate the effects of luteolin on CNE2 cells Fig 4.1: Combined effect of ... during the cell cycle where synthesis of both cyclins B1 and B2 is initiated during the interphase and localised in the cytoplasm During the prophase, cyclin B1 migrates fro...

Ngày tải lên: 10/09/2015, 15:53

Ngày tải lên: 23/03/2014, 05:22

... Uncovering the mechanism of 5-FU resistance and characterization of pyrimidine biosynthesis enzymes in C elegans will help to further our understanding of pyrimidine biosynthesis enzymes by filling in ... metabolic enzymes UP mediates the first step of 5-FU conversion We searched for homologs of the human pyrimidine biosynthesis enzymes, including uridin...

Ngày tải lên: 30/03/2014, 01:20