Role of nucleotide excision repair factors in genome maintenance in human cells under oxidative stress
Role of nucleotide excision repair factors in genome maintenance in human cells under oxidative stress
... been implicated in human progeroid phenotypes, indicating a dual role of repair factors in genome and telomere maintenance to regulate ageing homeostasis An example of these factors include the helicase ... Gopalakrishnan K, Sethu S, Manikandan J, Hande MP Role of DNA repair factors in telomere integrity and genome maintenance in mammalian cells under...
Báo cáo y học: "Decline of nucleotide excision repair capacity in aging Caenorhabditis elegan" potx
... contribution of TCR to repair in those targets Decline of DNA repair in aging C elegans and mammals We found that repair of UVC-damaged DNA was slower in aging (6 days after L4, corresponding to 60% of ... the concurrent decrease in repair capacity The use of the QPCR assay with C elegans permits the study of the formation and repair of many types of DN...
Báo cáo khoa học: Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA pptx
... damaged or inappropriate bases in DNA is base excision DNA repair (BER) [8–10] The initial step of BER involves enzymatic activities that process the N-glycosylic bonds linking the target bases and ... structurally distinct abasic sites, known as oxidized abasic sites Oxidized abasic sites include lesions at DNA strand breaks, such as 3¢-phosphoglycolate esters...
Báo cáo khoa học: Nucleotide excision repair rates in rat tissues pdf
... 2003 Nucleotide excision repair rates in rat tissues (Eur J Biochem 270) 1003 Fig NER rates in rat tissues Mixtures of pBlueScript irradiated at kJÆm)2 and unirradiated pEGFP-N1 were incubated in ... Ó FEBS 2003 Nucleotide excision repair rates in rat tissues (Eur J Biochem 270) 1001 suspension in RPMI 1640 medium, containing 4.5 mgÆmL)1 glucose in th...
Báo cáo khoa học: " The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection" ppsx
... chloride (NH4Cl) to pre- Figure Lack of HPV16 Infection in the absence of cathepsin B Lack of HPV16 Infection in the absence of cathepsin B HPV16 infection levels in cathepsin B and cathepsin L deficient ... cathepsin B or cathepsin L protease, Figure Cathepsin B and L treatment of HPV16 increases binding Cathepsin B and L treatment of HPV16 increases binding Repor...
Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... Both RPA and XPA preferentially bind damaged DNA, and because RPA and XPA directly interact in the absence of DNA, the RPA-XPA complex has been implicated as a key component in the earliest stage ... implicates the damaged DNA binding protein heterodimer in damage recognition, because the complex binds damaged DNA with high affinity [43] and can dramatically increase...
Báo cáo khoa học: The protein shuffle Sequential interactions among components of the human nucleotide excision repair pathway pdf
... ligation of a stretch of DNA to repair the gap created by the excision In TCR, stalled RNA polymerase II acts as a marker for recognition of the lesion by the DNA repair machinery With respect to the ... XPG The results of intricate studies designed to characterize these interactions are reviewed below Fig Scheme of the global genomic repair (GGR) pathway...
The Role of Genetically Modified Organisms (GMOs) in Beverage Production
... throughout the world bears little resemblance to teosinte, the original ancestor of corn The newer techniques involving genetic engineering, on the other hand, allow for the transfer of a few genes in ... Finally, the food and beverage industries hope that the next generation of GM products will deliver compelling consumer beneÞts THE FUTURE OF GENETICALLY MODIF...
Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... confirmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell cycle ... proteins with the promoter E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85] Another E2F site distal to the E2F ⁄ CDE acts...
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... role of AP-2a and AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an ... analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target...
Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx
... activation of the glutaminase reaction and CTP synthesis was compared (Fig 5) In the absence of GTP, the rate of glutamine hydrolysis was signicantly higher than the rate of CTP synthesis so that the reactions ... (min) Fig Isothermal titration calorimetry of the glutaminase activity of L lactis CTP synthase (A) Enthalpogram showing the r...
Báo cáo khoa học: Role of the C-terminal extension in a bacterial tyrosinase Michael Fairhead and Linda Thony-Meyer doc
... core tyrosinase domain [1] One proposed function of the C-terminal extension in plant and fungal polyphenol oxidases is a role in membrane binding, making them similar to the mammalian tyrosinases, ... three domains: a twin arginine translocase (TAT) signal peptide, a core domain containing the two copper-binding motifs and a C-terminal extension (Fig 1B)...
The Role of Small and Large Businesses in Economic Development doc
... innovation Small firms are the great innovators in some industries, while large firms are the great innovators in others Moreover, small and large businesses interact in innovative activity The ... businesses There is no clear evidence that small businesses are more effective innovators Further, the innovations of both small businesses and large busi...
Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx
... helix of the third cluster of CHCs is part of the inter-domain segment and the other helix lines the boundary between the major domain and the N-terminus (Fig 1) Therefore, the formation of the ... rather than functional role Role of hydrophobic contacts in serine hydroxymethyltransferase In the present study, the importance of the third hydrop...
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