Role of bcl 2 in metabolic and redox regulation via its effects on cytochrome c oxidase and mitochondrial functions in tumor cells

... treated CEM /Bcl- 2 cells Indeed, if MnSOD was engaged in blunting mitochondrial O2- increase in antimycin-treated CEM /Bcl- 2 cells due to increased activity in the context of Bcl- 2 overexpression, ... a conformational change in Bcl- 2, exposing its BH3 domain, converting Bcl- 2 from anti-apoptotic to pro-apoptotic (Lin, Kolluri et al 20 04) 1.6 Non-canonical...

Ngày tải lên: 14/09/2015, 08:42

... Immunohistochemical Localization of Bcl-2 in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis 281 Table Bcl-2 immunoreactivity in cell phenotypes of the spinal cords of normal and EAE rats ... Tae-Kyun Shin Fig Immunostaining for Bcl-2 (A, B) in EAE Intense Bcl-2 immunoreactivity is found in neurons and glial cells in...

Ngày tải lên: 07/08/2014, 15:20

... bone fracture healing J Bone Miner Res 2002, 17:963-976 Einhorn TA Do inhibitors of cyclooxygenase-2 impair bone healing? J Bone Miner Res 2002, 17:977-978 Zhang X, Schwarz EM, Young DA, Puzas ... activity of a glucocorticoid-regulated inflammatory cyclooxygenase Proc Natl Acad Sci USA 1992, 89:4888-4892 Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflammatory the...

Ngày tải lên: 09/08/2014, 01:21

... scanned and digital images of proteins were analyzed Calpain activity Calpain activity was measured as described by Tompa et al [26] Cells were washed with and scraped in ml of icecold PBS, and ... activation in a therapeutically useful manner In any case, the results here indicate that COX-2 is degraded by calpain, and that PIN1 regulates its expression via e...

Ngày tải lên: 11/08/2014, 08:22

... potent COX-2 inhibitor, etodolac, attenuated cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome This is the first report indicating the modulating role of COX-2 in ... important to clarify the potential mechanisms of chronic productive cough in patients suffering from sinobronchial syndrome to improve their symptoms...

Ngày tải lên: 13/08/2014, 10:20

... 28 2. 1 Fish Spawning and Maintenance 28 2. 2 Molecular Biology Techniques 28 2. 2.1 RT-PCR Molecular Cloning 28 2. 2 .2 Polymerase Chain Reaction (PCR) 29 2. 2.3 Agarose Gel Electrophoresis 29 2. 2.4 ... prior finding of possibly interacting proteins of BNIP- 2 led to the formation of research questions: Does the physical interaction of BNIP- 2 with these prote...

Ngày tải lên: 05/10/2015, 19:05

... Rhee SG (20 01) Inactivation of human FEBS Journal 27 5 (20 08) 29 42 29 55 ª 20 08 The Authors Journal compilation ª 20 08 FEBS 29 53 Cysteinyl-based modification of the 20 S proteasome 10 11 12 13 14 15 ... investigating whether that common feature is related to their easy entry into the latent 20 S particle Cysteinyl-based modification of the 20 S proteasome...

Ngày tải lên: 23/03/2014, 07:20

... to the solvent, thus allowing for the binding of larger substituents (Fig 2A) The CH atoms of the substrate ring at positions and point towards the backbone of Leu248 and the side chain of Thr249, ... shown) The contacts between the edge of the dihydroxylated substrate ring and the active site pocket are probably involved in the determination of...

Ngày tải lên: 30/03/2014, 10:20

... Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells Journal of Translational ... DNR-insensitive CD34+ AML cell lines (KG1a and Kasumi-1) and in CD34+ primary AML samples We showed that curcumin selective...

Ngày tải lên: 18/06/2014, 19:20

... efficacy of the bcl-2 ASO G3139 on mice bearing human melanoma in combination chemotherapy, in order to identify an innovative approach for antisense delivery to tumors and to increase the response of ... those areas where aggressive surgery is not feasible, such as head and neck melanoma Adjuvant therapies of metastatic melanoma have been unrewarding with...

Ngày tải lên: 18/06/2014, 22:20

... tumors and to increase the response of melanoma to therapy The rationale for the use of G3139 is based on the relevant role of bcl-2 in melanoma cell survival and on the increased sensitivity of ... whether electroporation could increase the efficacy of the bcl-2 ASO G3139 on mice bearing human melanoma in combination chemotherapy, in ord...

Ngày tải lên: 20/06/2014, 04:20

... article as: Hughes-Fulford and Li: The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization Journal of Orthopaedic Surgery and Research 2011 6:8 Submit ... Figure FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in...

Ngày tải lên: 20/06/2014, 04:20

... article as: Hughes-Fulford and Li: The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization Journal of Orthopaedic Surgery and Research 2011 6:8 Submit ... Figure FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in...

Ngày tải lên: 20/06/2014, 07:20

... cytokines than the ContDCs, at 24, 48 h of incubation time (Fig 2) However, the taxol concentration used was critical for the level of cytokine production; μg/ml of taxol induced only marginal ... by that of the β-actin band, and the ratio at h was set at 100% (B) Fig NF-κB involvement in the taxol- induced effects on dendritic cells (DCs) The mobilization...

Ngày tải lên: 07/08/2014, 23:22