Human telomerase reverse transcriptase (hTERT) overexpression modulates intracellular redox balance and protects cancer cells from apoptotic cell death

... normal and cancer cells could be a valuable approach to target cancer cells for cell death One of the glaring differences between normal cells and cancer cells is their difference in telomerase ... overexpressing cells .…………………………………… 126 4.4 hTERT overexpression can protect cells from H2O2 induced cell death .130 4.5 hTERT overexpression can protect cell...

Ngày tải lên: 14/09/2015, 08:38

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Ngày tải lên: 07/08/2014, 20:23

... with one of the mutated forms of HBZ (lanes and 8) These findings demonstrate that HBZ acts synergistically with JunD to increase the transcription of the hTERT gene To verify that HBZ plays a direct ... Consequently, the activity of HBZ/ JunD is independent of the DNA-binding properties of JunD, but instead requires the interaction of these bZI...

Ngày tải lên: 13/08/2014, 05:22

... biochemical < /b> analysis < /b> of < /b> the subtype < /b> B and C RT enzymes < /b> Results Purification of < /b> recombinant < /b> HIV-1 < /b> RTs from subtype < /b> B and subtype < /b> C The subtype < /b> C HIV-1 < /b> RT sequence used in this study differs from ... Comparative biochemical < /b> analysis < /b> of < /b> recombinant < /b> reverse < /b> transcriptase...

Ngày tải lên: 13/08/2014, 01:20

... 27 0) Fig Homo -oligomerization of D2 dopamine receptors expressed in Spodoptera frugiperda (Sf 9) and HEK 293 cells (A) Intact Sf9 cells expressing FLAG-tagged dopamine D2L receptors (black bars) ... co-immunoprecipitation and time-resolved FRET to monitor the oligomerization of the D2L and D2S receptors expressed in Spodoptera frugiperda...

Ngày tải lên: 21/02/2014, 00:20

... Role of JNK in radiation- induced mitochondrial cell death M.-J Kim et al Fig Ionizing radiation induces expression of Fas and activation of caspases in human cervical cancer cells (A) Ionizing radiation- induced ... development of molecular targets for cancer treatment Results To examine the kinetics of the apoptotic cell death induced by ionizi...

Ngày tải lên: 07/03/2014, 05:20

... MICA or MICB The CALO and INBL cervical cancer cell lines secrete MICA and MICB and express NKG2D U-937 Figure MICA and MICB induce leukemic myelomonocytic cell line proliferation TPH-1 and U937 ... expressed in leukemic myelomonocytic cell lines Flow cytometric analysis of NKG2D expression in the leukemic myelomonocytic TPH-1 and U937 cell lines...

Ngày tải lên: 10/08/2014, 10:21

... directed by human immunodeficiency virus particles J Virol 19 94, 68 :11 79 -11 85 Brussel A, Sonigo P: Analysis of early human immunodeficiency virus type DNA synthesis by use of a new sensitive assay for ... fixation HuR 96h B D1:siRNA D2:siRNA D4:infection D5:staining 16 0 14 0 12 0 10 0 80 60 40 20 H2O HuR- 1 HuR- 2 HuR- 3 Ctrl siRNA C D 12 0 siRNA Ctrl siRNA H...

Ngày tải lên: 13/08/2014, 05:20

... Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease Retrovirology 2010 7:89 Submit your next ... killing of HIV- 1 infected cells may also be exploited to target persistent reservoirs of HIV producing cells The existence of such reservoirs that diffe...

Ngày tải lên: 13/08/2014, 01:20

... phosphorylated in vitro by a number of kinases including auto-activated protein kinase (AK), myelin basic protein kinase (MBPK), cytosolic protamine kinase (CPK), casein http://www.retrovirology.com/content/5/1/115 ... Capony JP, Canard B: Phosphorylation of AZT-resistant human immunodeficiency virus type reverse transcriptase by casein kinase II in vitro: effects on inhibitor s...

Ngày tải lên: 13/08/2014, 05:21

... which was slightly active on the wild-type RT RNase H function, showed a sixfold increase in the inhibition potency of the RNase H function, although it retained its inhibition potency on the ... AQ derivatives and other RT inhibitors (A) YonetaniTheorell plot of the combination of K-49 and RDS 1643 on the HIV-1 RT polymeraseindependent RNase H a...

Ngày tải lên: 22/03/2014, 16:20

... analysis of the processivity and the fidelity of DNA synthesis (namely, the ability of BLV RT to misincorporate nucleotides at the 3¢ end of the growing DNA strand and the further extending of the ... multiple-round synthesis (Fig 1) The analysis of the processivity of DNA synthesis in the presence of a DNA trap suggests that BLV RT...

Ngày tải lên: 31/03/2014, 21:21

... of Helsinki Pre-processing of blood samples Blood samples were collected in EDTA-containing tubes Sample processing was performed within hours after blood withdrawal Blood was transferred into ... mRNA was used to investigate the possibility of peripheral blood as a source for CTC detection and prediction of cancer recurrence in gastric carcinoma patients Real-tim...

Ngày tải lên: 18/06/2014, 16:20

... microglia, and astrocytes by Sargassum fusiforme AIDS Res Ther 2006, 3:15 Hoshino T, Hayashi T, Hayashi K, Hamada J, Lee JB, Sankawa U: An antivirally active sulfated polysaccharide from Sargassum ... experiments 16 Acknowledgements We wish to thank K Thornber and T Havens for translation of Japanese Sargassum literature, and Dr Carlos de Noronha for discussion and useful co...

Ngày tải lên: 20/06/2014, 01:20

... http://www.jiasociety.org/content/7/1/69 Substitutions < /b> Figure untreated patients Numbers of < /b> nucleotide substitutions < /b> in < /b> RT and < /b> PR in < /b> Numbers of < /b> nucleotide substitutions < /b> in < /b> RT and < /b> PR in < /b> untreated patients (Values represent ... synthesis of < /b> the < /b> negative strand of < /b> DNA can result in < /b> t...

Ngày tải lên: 20/06/2014, 08:20