Clinical pharmacokinetics of tacrolimus in asian liver transplant patients

... 123 24 Final population PK model of Tac in Asian adult and paediatric liver transplant patients and its parameters 125 25 Final population PK model of Tac in Asian liver transplant patients ... relationships in Asian liver transplant patients between the PK of Tac and arthropometric characteristics of the patients, as well as the clinical conditions of the patients Using these models, in conjunction ... population PK of Tac in the local Asian adult and paediatric liver transplant recipients In the first study, the population pharmacokinetics (PK) of intravenous and oral Tac was determined in 20 Asian...

Pharmacogenetics of doxorubicin in asian breast cancer patients

... pharmacokinetics of doxorubicin and doxorubicinol in Asian breast cancer patients The influence of ABCB1 linked polymorphisms on the pharmacokinetics of doxorubicin and doxorubicinol in Asian breast cancer ... frequency of ABCC5 polymorphisms in Asian breast cancer patients 153 Table 3.15 The influence of ABCC5 polymorphisms on pharmacokinetics of doxorubicin and doxorubicinol in Asian breast cancer patients ... in Asian ethnic groups and breast cancer patients 190 Table 3.26 The influence of CBR1 polymorphisms on pharmacokinetics of doxorubicin and doxorubicinol in Asian breast cancer patients The influence...

Báo cáo khoa học: "Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs" doc

... J, Gauze JJ, Greco DS, Weise DW, Buck JM Pharmacokinetics of norfloxacin in dogs after single intravenous and single and multiple oral administrations of the drug Am J Vet Res 1990, 51, 1065-1070 ... Med Sci 1996, 58, 1039-1040 17 Park SC, Yun HI Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and intramuscular administration to horses Res Vet Sci 2003, 74, 79-83 ... norfloxacin in chickens, turkeys and geese after a single oral administration J Vet Pharmacol Ther 1998, 21, 161-164 13 Lavy E, Ziv G, Glickman A Intravenous disposition kinetics, oral and intramuscular...

Báo cáo y học: "Induction of procalcitonin in liver transplant patients treated with anti-thymocyte globul" potx

... monitoring of PCT is its dynamics In our study, in both groups of patients receiving immunosuppressive therapy, an elevated level of PCT was found, especially in the group of ATG -treated patients ... Figure Procalcitonin (PCT) serum levels in patients after orthotopic liver transplantation (OLTx) with and without anti-thymocyte globulin (ATG) therapy and after liver resection after liver resection ... C-reactive protein (CRP) serum levels in patients after orthotopic liver transplantation (OLTx) with and without anti-thymocyte globulin (ATG) therapy and after liver resection and after liver resection...

A double blind randomized placebo controlled clinical trial on the supplementation of probiotics in the first six months of life in asian infants at risk of allergic diseases effe

... efficacy to vaccination Objectives: To assess the effect of probiotic supplementation in the first months of life on i allergic diseases at two years of age in Asian infants at risk of allergic ... SUMMARY OF CLINICAL TRIALS EVALUATING EFFECTS OF PROBIOTICS ON PARENTERAL VACCINATION 23 TABLE 1-4 SUMMARY OF CLINICAL TRIALS EVALUATING THE ROLE OF PROBIOTIC SUPPLEMENTATION IN THE TREATMENT ... administration of probiotics from birth on the prevention of allergic sensitization and allergic diseases At the initiation of this clinical trial, very few randomized trials had been reported to evaluate...

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Báo cáo khoa học: "Modification of pharmacokinetics of cefotaxime in uranyl nitrate-induced renal damage in black bengal goats" pps

... AK Pharmacokinetics of cefotaxime in experimentally induced kidney damage in goats Indian J Pharmacol 2003, 35, 173176 Jha K, Roy BK, Singh RCP The effect of induced fever on the biokinetics of ... i.m administration The fc and T~P values indicated shorter persistence of the drug in tissue compartment of normal Modification of cefotaxime kinetics Table Pharmacokinetic parameters of cefotaxime ... concentration of cefotaxime at different time intervals after single dose i.m administration at 50 mg/ kg in kidney damaged goats were presented in Fig Cefotaxime could be detected in the plasma of goats...

Báo cáo y học: "The clinical relevance of autoantibodies in scleroderma" pdf

... been strongly associated with CREST, a variant of SSc, defined by the presence of calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, and telangectasia [11] Finding ACA can ... frequency of puffy fingers, small bowel involvement, hypothyroidism, and a greater risk for reduced survival at 10 years [85], succumbing primarily to pulmonary arterial hypertension In still ... myocardial ischemia and pulmonary hypertension indicate a need for further study before any clear place of aPL determinations in patients with SSc can be recommended Similarly, the clinical relevance...

Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx

... arthritis may be induced by systemic autoreactivity remains interesting and plausible G6PIinduced arthritis provides a model in which both the induction and modulation of arthritis induced by autoreactivity ... autoreactivity against the ubiquitously expressed glycolytic enzyme G6PI specifically induces arthritis, with no other symptoms of organ-specific or systemic autoimmune disease Interestingly, although ... the development of arthritis in the K/B×N model are involved in human RA Both experimental and clinical data strongly support the possibility that autoreactivity against systemically expressed autoantigens...

Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx

... efficacy This systematic review and meta-analysis of celecoxib in osteoarthritis and rheumatoid arthritis was conducted using information from company clinical trial reports, supplied by Pfizer ... cardiac adverse events [26] Cochrane reviews of cyclooxygenase inhibitors in rheumatoid arthritis have limited information to date on efficacy and safety of rofecoxib [27], and only five trials ... patients taking celecoxib [28] Two previous systematic reviews of coxibs used company clinical trial reports Deeks and co-workers [29] examined 15,000 patients in nine of the earlier trials of celecoxib, ...

Báo cáo y học: " Correction: Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports" docx

...

Báo cáo y học: "Proteinases in the joint: clinical relevance of proteinases in joint destruction Yvonne Rengel, Caroline Ospelt and Steffen Gay" doc

... into five families: the serralysins, the astacins, the adamalysins, the MMPs and the pappalysins [5] The family of MMPs is best known for its ability to cleave components of the ECM, but they ... fibronectin fragments, are released into the joint fluid and irritate the synovial membrane lining in the joint space The resulting synovitis provokes release of inflammatory mediators from synovial ... This family of agents includes tetracycline, doxycycline, minocycline and the tetracycline analogues that have been chemically modified to eliminate their antimicrobial activity Inhibition of signal...

Báo cáo y học: " Vibrio parahemolyticus septicaemia in a liver transplant patient: a case report" ppt

... complemented with broad spectrum antibiotic therapy V parahemolyticus demonstrates beta-lactamase activity in as many as 50% of isolates [8] The vibrios are susceptible most notably to fluoroquinolones, ... utensils contaminated with seawater or translocation from the gastrointestinal tract [6] Bacteraemia and septicaemia occur in three to five percent of Vibrio infections and is a concern in immunocompromised ... disease, kidney disease, heart disease, recent gastric surgery, or antacid use [4,6] Wound infection may occur after contamination of skin laceration with warm seawater, after direct trauma with...

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