TDT for human QTL mapping and genome wide association study

... TDT FOR HUMAN QTL MAPPING AND GENOME- WIDE ASSOCIATION STUDY HAO YING (Master of Science, National University of Singapore ) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR ... 43 3.3 TDT for QTL mapping by ERS 48 3.4 The power of TDT with ERS 50 CONTENTS v TDT in Genome- wide Association Study 57 4.1 FDR-controlling ... logistic model for TDT 62 Gen...

Ngày tải lên: 11/09/2015, 16:06

... problems in GWAS: tag SNP selection and SNP imputation Tag SNP selection aims at selecting a small number of SNPs (called tag SNPs) from a large number of SNPs using the non-random association (linkage ... GWAS: tag SNP selection and SNP imputation A novel algorithm called FastTagger is developed to reduce the number of tag SNPs and to improve efficiency FastTagger i...

Ngày tải lên: 09/09/2015, 10:06

... linkers, amplification of targeted DNA, purification of amplified DNA, labeling, hybridization, and scanning The Affymetrix GeneChip® Human Mapping 500K Array was used Scanning and analysis were performed ... subsequently genotyped in patients with Behçet's disease and controls using a case-control genetic association approach and the TaqMan SNP Genotyping Assays (Applied Biosys...

Ngày tải lên: 09/08/2014, 14:20

... testing of smoking will result in public health improvements [18] and reduce the likelihood of harm; such harm could include a lowering of the motivation to quit or of the self-efficacy for quitting, ... patients [20] The coordinated effort of multidisciplinary research teams that address these complex issues will help inform the circumstances under which we can tr...

Ngày tải lên: 11/08/2014, 12:20

... of Genome- Wide Association Study for NBA in LW_2b 196 SI 4: Manhattan plot of Genome- Wide Association Study for NBA in LW_3 197 SI 5: Manhattan plot of Genome- Wide Association Study for ... Supplementary Information LIST OF SUPPLEMENTARY INFORMATION SI 1: Manhattan plot of Genome- Wide Association Study for NBA in LW_2 196 SI 2: Manhattan plot of...

Ngày tải lên: 26/11/2015, 10:18

... monozygous twins, full siblings, and parent-offspring In each instance, the sample with the higher call-rate was retained in the analysis Analysis of association statistics After sample and SNP quality ... Working Group, Medical Faculty, University of Indonesia, Jakarta, Indonesia 8Samara Oblast Tuberculosis Dispensary, Samara City, Samara, Russian Federation 9Clinical TB and HIV...

Ngày tải lên: 06/03/2014, 04:20

... susceptibility to melanoma may also result in high-risk predisposition to other such forms of cutaneous malignancies [12] Risk variants of cutaneous malignancies Association with pigmentation phenotype and ... 1)) for CM and BCC risk Three cohorts (810 individuals with CM and 36,723 non-CM controls from Iceland; 1,033 CM cases and 2,650 controls from Sweden and...

Ngày tải lên: 11/08/2014, 12:20

... case (P-Hat) The median of the cumulative genetic risk in the case group is 0.90, and in the control group 0.01 Quantiles of the estimated cumulative genetic risk (PHat) using different genetic models ... accuracy in the independent dataset despite a median cumulative genetic risk in the discovery dataset of 0.90 for the case group, and 0.01 for the c...

Ngày tải lên: 11/08/2014, 12:21

... myeloid leukemia (CML), in a reverse way by blocking the activity of the fusion protein using the tyrosine-kinase inhibitory drug imatinib mesylate As shown in Table 1, ontological analysis of ... was the 'EGF receptor pathway', individual members of which are known to become phosphorylated/activated by BCR/ABL1 Taken together, these findings support the validity of the...

Ngày tải lên: 14/08/2014, 07:21

... sizes and lowering limitIBD for clustering haplotypes decreased the number of base and non-base haplotypes Increasing the numbers of base haplotypes decreased the number of additional non-base haplotypes ... and clustering of related haplotypes Two types of haplotypes were considered: 1) the haplotypes of the first generation of genotyped an...

Ngày tải lên: 14/08/2014, 13:21

... subunits were induced by C independent of N and, in many instances, also by C in interaction with N Components of the proteasome were induced by C independent of N, and also by C in interaction ... multinetwork tool to integrate information for gene interactions based on a variety of data, including: Arabidopsis metabolic pathways; known protein-protein, protein-DNA, and miRNA-RNA...

Ngày tải lên: 14/08/2014, 17:22

... genome analysis of T gammatolerans EJ3 and a detailed comparison with other Thermococcales genomes To gain real insights into the physiology of T gammatolerans, we analyzed the proteome content of ... plasticity in Thermococcales The six closely related and fully sequenced Thermococcales species (three Thermococcus, T gammatolerans, T kodakaraensis, and T onnurineus,...

Ngày tải lên: 14/08/2014, 21:20

... feature selection methods confined to genome- wide association studies in Subsection Chapter1: Introduction 1.3.1 Model selection methods and some feature selection methods incorporated into model selection ... original SCAD method Chapter 3: Model selection criterion in generalized linear models 37 Chapter Model Selection Criteria in Generalized Linea...

Ngày tải lên: 11/09/2015, 16:05

... the key pathways involved in lupus pathogenesis, with each pathway constructed of a number of interacting proteins making an individual contribution to disease susceptibility Page of (page number ... Arthritis Research & Therapy Vol 11 No Cunninghame Graham reproducibility between GWAS may reflect an overall lack of power for each individual study, since each published GWAS was of inter...

Ngày tải lên: 09/08/2014, 14:22

... as: Sugino H, et al.: DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies Arthritis Research & Therapy 2010, 12:401 ... financially supported partly by the grant from the Ministry of Health, Labor and Welfare of Japan Author details Graduate School of Frontier Bioscience, Osaka University, 1-3 Yam...

Ngày tải lên: 12/08/2014, 11:23