identification through genome wide association screen

Báo cáo y học: "Identification of novel genetic susceptibility loci for Behçet''''s disease using a genome-wide association study" pps

Ngày tải lên : 09/08/2014, 14:20

... strong association in the HLA region, other genetic associations are largely unconfirmed We hypothesize that novel genetic loci for Behçet's disease will be identified using an unbiased genome- wide ... will be identified using an unbiased genome- wide association approach Herein, we used a DNA pooling technology to perform the first genome- wide association study in Behçet's disease We identify ... candidate genes based on the unbiased genome- wide pooling association study Individual case-control genotyping using TaqMan SNP Genotyping Assays confirmed the genetic association between SNPs in five...

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A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians doc

Ngày tải lên : 06/03/2014, 04:20

... 10-7 (0.05/95,207) is required to declare genome wide significance in this study Stage 3: testing TB association in Russian cohort Among the top SNP associations detected in the first two stages ... analysis Analysis of association statistics After sample and SNP quality control, statistics of association were calculated using the PLINK software package [26] For detecting associations in the ... was performed to stratify the association analysis by cohort A stringent Bonferroni corrected alpha of P = 5.25 × 10-7 (0.05/95,207) is required to declare genome wide significance in this study...

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Báo cáo y học: "Genome-wide association studies in systemic lupus erythematosus: a perspective" docx

Ngày tải lên : 09/08/2014, 14:22

... Non-replication and inconsistency in the genome- wide association setting Hum Hered 2007, 64:203213 Neale BM, Purcell S: The positives, protocols and perils of genome- wide association Am J Med Genet 2008, ... corrects for stratification in genome- wide association studies Nat Genet 2006, 38: 904-909 10 Li M, Li C, Guan W: Evaluation of coverage variation of SNP chips for genome- wide association studies Eur ... Merrill JT, Gilkeson GS, Seldin MF, Yin H, Baechler EC, Li QZ, Wakeland EK, Bruner GR, et al.: Genome- wide association scan in women with systemic lupus erythematosus identifies susceptibility variants...

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Báo cáo y học: " Stress response regulators identified through genome-wide transcriptome analysis of the (p) ppGpp-dependent response in Rhizobium " docx

Ngày tải lên : 09/08/2014, 22:23

... RhizoBase [http:/ /genome. kazusa.or.jp/rhizobase/] doi:10.1186/gb-2011-12-2-r17 Cite this article as: Vercruysse et al.: Stress response regulators identified through genome- wide transcriptome ... F: Identification of RpoS (sigma(S))-regulated genes in Salmonella enterica serovar typhimurium J Bacteriol 2000, 182:5749-5756 46 Weber H, Polen T, Heuveling J, Wendisch VF, Hengge R: Genome- wide ... a-proteobacterium, revealing notable differences from the well-studied role Vercruysse et al Genome Biology 2011, 12:R17 http://genomebiology.com/2011/12/2/R17 of (p)ppGpp in E coli Of the many detected (p)ppGpp...

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báo cáo khoa học: " Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies" pdf

Ngày tải lên : 11/08/2014, 12:20

... CDKN2A/B [12] No association BCC, no association to CM KRT5, G138E substitution [12] No association BCC, no association to CM 7q32 adjacent to KLF14 [12] No association BCC, no association to CM ... effort from ten GenoMEL groups with 1,650 cases and 1,065 controls The team identified five loci on chromosomes 2, 5, 9, 11 and 16, with at least one SNP at each locus with genomewide significance ... Hoiom V, Hopper JL, Ingvar C, Kanetsky PA, Kefford RF, Landi MT, Lang J, Lubinski J, et al.: Genome- wide association study identifies three loci associated with melanoma risk Nat Genet 2009, 41:920-925...

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báo cáo khoa học: " The public health utility of genome-wide association study results for smoking behavior" docx

Ngày tải lên : 11/08/2014, 12:20

... D, Uhl GR: Genomewide association for nicotine dependence and smoking cessation success in NIH research volunteers Mol Med 2009, 15:21-27 Guessous I, Gwinn M, Khoury MJ: Genome- wide association ... Cite this article as: Furberg H, et al.: The public health utility of genomewide association study results for smoking behavior Genome Medicine 2010, 2:26 ... Saccone SF, Wang JC, Chase GA, Rice JP, Ballinger DG: Novel genes identified in a high-density genome wide association study for nicotine dependence Hum Mol Genet 2007, 16:24-35 Amos CI, Wu X, Broderick...

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báo cáo khoa học: "Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data" ppt

Ngày tải lên : 11/08/2014, 12:21

... multiple sclerosis identified by a genomewide study N Engl J Med 2007, 357:851-862 12 Australian and New Zealand Multiple Sclerosis Genetics Consortium: Genome- wide association study identifies new ... as: Wang et al.: Modeling the cumulative genetic risk for multiple sclerosis from genome- wide association data Genome Medicine 2011 3:3 Submit your next manuscript to BioMed Central and take full ... failed to achieve genome- wide significance We then tested whether a significant fraction of the variance was related to contributions from additional common alleles with lower association effects...

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Báo cáo y học: " DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies" docx

Ngày tải lên : 12/08/2014, 11:23

... http://arthritis-research.com/content/12/2/401 Page of Table Candidate genes identified from rheumatoid arthritis genome- wide association studies Gene GeneID PMID Gene expression (up or down) Microarray P valuesa CD244 ... between 112 rheumatoid arthritis patients and 45 healthy individuals Abbreviations GWAS, genome- wide association studies; RA, rheumatoid arthritis Competing interests This study was financially ... Gallick GE, Gorlova OY, Amos C, Logothetis CJ: GWAS meets microarray: are the results of genome wide association studies and geneexpression profiling consistent? Prostate cancer as an example...

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GENOME WIDE ASSOCIATION STUDIES OF CORONARY ARTERY DISEASE IN SINGAPOREAN CHINESE POPULATIONS

Ngày tải lên : 09/09/2015, 08:17

... basis of CAD Genome wide association analysis, which is a powerful tool to identify genetic variants, is commonly employed to identify novel genetic variants currently Most genome wide association ... infarction 92 Figure 11 Summary of genome wide association analysis of HDL-C The Manhattan plot summarizes the genotyped and imputed genome wide association results in the left panel Loci ... 2,393 samples 72 Figure Flow chart of genome wide scan of SNPs associated with CAD 77 Figure Summary of genome wide association of 2,379 samples on 796,922 SNPs The left panel...

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Efficient computational techniques for tag SNP selection, epistasis analysis, and genome wide association study

Ngày tải lên : 09/09/2015, 10:06

... Introduction 1.1 1.1.1 Motivation Genome- wide association studies (GWAS) A genome- wide association study (GWAS) searches for inherent expression (genetic patterns) from a genome that is potentially ... memory-intensive tag SNP selection methods in the literature cannot work on genome- wide data So we propose a fast and eﬃcient genomewide tag SNP selection algorithm (called FastTagger) using multi-marker ... 1.1.1 Genome- wide association studies (GWAS) 1.1.2 Computational challenges in GWAS 1.1.3 Big data, Hadoop and associated technologies 1.1.4 Hadoop in genome analysis ...

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Model selection methods and their application in genome wide association studies

Ngày tải lên : 11/09/2015, 16:05

... in Genomewide Association Studies 72 5.1 Introduction to the multiple testing for genome- wide association studies 73 5.2 The generalized tournament screening cum EBIC approach for genomewide association ... the dimension P is large Such a problem has become especially prevalent in genome- wide association studies A genome- wide association study (GWAS) is a promising way to detect genetic variants responsible ... selection are reviewed in Subsection 1.3.2 1.3.1 Feature selection methods in genome- wide association studies In genome- wide association studies, a large number of statistical studies have been developed...

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TDT for human QTL mapping and genome wide association study

Ngày tải lên : 11/09/2015, 16:06

... ERS 50 CONTENTS v TDT in Genome- wide Association Study 57 4.1 FDR-controlling procedure 58 4.2 Genome- wide TDT procedure using logistic model and feature ... has not been applied to genome- wide association study yet In this thesis, we provide an eﬃcient logistic model and an algorithm to search the causal genes in the genome- wide scope This algorithm ... glmpath 64 4.2.3 Genome- wide mapping procedure 67 4.2.4 4.3 Introduction to logistic model for TDT 62 Genome- wide TDT for QTL mapping ...

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Genome wide association study for reproduction traits in maternal pig breeds

Ngày tải lên : 26/11/2015, 10:18

... Manhattan plot of Genome- Wide Association Study for NBA in LW_2 196 SI 2: Manhattan plot of Genome- Wide Association Study for NBA in LW_2a 196 SI 3: Manhattan plot of Genome- Wide Association Study ... Manhattan plot of Genome- Wide Association Study for NBA in LW_3 197 SI 5: Manhattan plot of Genome- Wide Association Study for NBA in LR_1 197 SI 6: Manhattan plot of Genome- Wide Association Study ... Manhattan plot of Genome- Wide Association Study for NBA in LR_3 198 SI 8: Manhattan plot of Genome- Wide Association Study for NBA in LR_3a 198 SI 9: Manhattan plot of Genome- Wide Association...

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Báo cáo y học: "Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network" pps

Ngày tải lên : 09/08/2014, 20:20

... FLN in worm The resulting genome- scale FLN network consists of 21,657 genes (covering approximately Genome Biology 2009, 10:R91 http://genomebiology.com/2009/10/9/R91 Genome Biology 2009, P rotein ... cannot be narrowed down This set is referred to as the genome background Genome Biology 2009, 10:R91 http://genomebiology.com/2009/10/9/R91 (a) Genome Biology 2009, Volume 10, Issue 9, Article R91 ... disease-disease association in a quantitative way We compare our method with another available disease-disease association identification method proposed by Goh et al., which identifies the associations...

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Báo cáo y học: "Design and evaluation of genome-wide libraries for RNA interference screens" pps

Ngày tải lên : 09/08/2014, 20:22

... occur through perfect and imperfect sequence homologies to the siRNA and through 'seed matches' to the transcript 3' UTRs See text for details Horn et al Genome Biology 2010, 11:R61 http://genomebiology.com/2010/11/6/R61 ... re-annotate existing genome- wide libraries For example, we have applied the algorithm to re-annotate RNAi libraries for Drosophila and human cells Our analysis of eight genome- wide RNAi libraries ... libraries for genome- scale experiments RNAi screens rely on the design of large-scale libraries comprehensively covering annotated transcriptomes The design of RNAi libraries requires the identification...

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báo cáo khoa học: " Identification of rhizome-specific genes by genome-wide differential expression Analysis in Oryza longistaminata" doc

Ngày tải lên : 11/08/2014, 11:21

... bicolor genome and the diversification of grasses Nature 2009, 457(7229):551-556 doi:10.1186/1471-2229-11-18 Cite this article as: Hu et al.: Identification of rhizome-specific genes by genome- wide ... University and BGI [19-23] These DNA microarrays have been used for many purposes, especially for genome- wide transcriptome analyses in different cells/tissues/organs or developmental stages of rice ... understand the molecular mechanisms of tissue specificity in O longistaminata by exploring the genome- wide gene expression patterns Our results provide insights into the genes and molecular mechanisms...

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báo cáo khoa học: " Genome-wide identification and analyses of the rice calmodulin and related potential calcium sensor proteins" pdf

Ngày tải lên : 12/08/2014, 05:20

... Nucleic Acids Res 1999, 25(24):4876-4882 Asano T, Tanaka N, Yang G, Hayashi N, Kamatsu S: Genome- wide identification of the rice calcium-dependent protein kinase and its closely related kinase ... and Discussion Identification and phylogenetic analysis of EF-handcontaining proteins To identify EF-hand-containing proteins, firstly, we functionally searched the Oryza sativa L genome at The ... Chromosomal distribution of the OsCam and OsCML genes in the rice genome Figure Chromosomal distribution of the OsCam and OsCML genes in the rice genome The chromosome numbers are shown at the bottom; horizontal...

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Báo cáo y học: "Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma" docx

Ngày tải lên : 14/08/2014, 07:21

... magnification of 100× Genome Biology 2007, 8:R78 http://genomebiology.com/2007/8/5/R78 Genome Biology 2007, Gene Ontology annotation revealed the unique nature of clustered genes information Genome Biology ... Michigan (UMSCC), derived from eight patients with aggressive HNSCC Genome Biology 2007, 8:R78 http://genomebiology.com/2007/8/5/R78 Genome Biology 2007, Volume 8, Issue 5, Article R78 Yan et al R78.3 ... R78 R78.6 Genome Biology 2007, Volume 8, Issue 5, Article R78 Yan et al http://genomebiology.com/2007/8/5/R78 (a) (b) wt p53-like -2 mt p53 Clusters (c) Figure (see legend on next page) Genome Biology...

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Báo cáo y học: "A pathway sensor for genome-wide screens of intracellular proteolytic cleavage" ppt

Ngày tải lên : 14/08/2014, 08:21

... systems for monitoring apoptosis and autophagy and describe applications of this reporter in genome- wide screening approaches respectively; Figure 1b), while MG132, an inhibitor of the proteasome, ... cellular lysates in triplicate plates To normalize for cellu- Genome Biology 2008, 9:R64 http://genomebiology.com/2008/9/4/R64 (a) Genome Biology 2008, Volume 9, Issue 4, Article R64 Ketteler ... Overlap of GFP-dNGLUC and Golgin67-DsRed is marked by an arrow Genome Biology 2008, 9:R64 http://genomebiology.com/2008/9/4/R64 Genome Biology 2008, lar expression and cell numbers, we determined...

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Báo cáo y học: "Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors" pps

Ngày tải lên : 14/08/2014, 17:22

... protein; U2AF, U2 small nuclear RNP auxiliary factor Genome Biology 2006, 7:R113 http://genomebiology.com/2006/7/11/R113 Genome Biology 2006, information Genome Biology 2006, 7:R113 interactions Next, ... PTB-associated in our screen A role for PTB as an internal ribosome entry segment (IRES) trans-acting factor Genome Biology 2006, 7:R113 http://genomebiology.com/2006/7/11/R113 Genome Biology 2006, ... manuscript This work Genome Biology 2006, 7:R113 http://genomebiology.com/2006/7/11/R113 Genome Biology 2006, 11 12 13 15 16 17 19 20 21 23 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 Genome Biology...

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