myelin model implications for human brain function and dysfunction

... the imbedding and histomorphometric techniques specific for the needs of this model; XD performed critical macroscopic and microscopic analysis of the histologic specimens; and TK and GD participated ... versus histologic neuroma formation in a rabbit forelimb amputation model: potential implications for the operative treatment and study of neuromas Journal of Brachial Plexus and Peripheral Nerve ... < 0.0001 for distal end, 5, 10, and 15 mm proximally) and in the ulnar nerve (p < 0.0001 for distal end, 5, 10, and 15 mm group) Discussion Inspired by findings both in the laboratory and in the...

Ngày tải lên: 10/08/2014, 10:20

... each cell type (AC, AF and NP) along with the mean combined intensity for AC and AF cells and the calculated fold change values (positive and negative) between NP and AC and AF cells that were ... and ACAN between NP and AF or AF and AC cells However, there were small, but significant, increases in gene expression for COL2A1 and ACAN in AC cells when compared with NP cells (P = 0.011 and ... for differences between human NP and AC cells, so it remains unclear whether CD24 can indeed be used for distinguishing human NP cells More recently studies have utilised microarrays in rat and...

Ngày tải lên: 12/08/2014, 11:23

... establishes the theoretical model, which includes a general model and a specific formulation of the general model The general model provides detailed articulation of the model setup and addresses the issue ... production and utility functions The specific form of the model is built on Glaeser and Gottlieb(2009) with Cobb-Douglas functions of the traded and non-traded goods productions, the household’s and ... Mieszkowski, 1986), another is referred to land rent (or land value), and others consist of both land and its improvement (Arnott and MacKinnon, 1977; Polinsky and Rubinfeld, 1978; Brueckner, 1981;...

Ngày tải lên: 10/09/2015, 09:07

... onwards were available For each of these years, logistic models were fit to data for males and females combined and to data for females only using generalized linear models and assuming a binomial ... ratios (Fig 2b) Modelled values for sl (Fig 2b) were used to estimate the len-FSB (eq 3) and lenTEP (eq 4) For the years 1980–1984, the average of the modelled values for 1979 and 1985 were used ... Norwegian data and described the aggregate stock (immature and mature combined, males and females combined) They were constructed for cm length groups ranging from to 140+ cm and ages to 13+, and each...

Ngày tải lên: 14/03/2014, 16:20

... simulates atmospheric and land processes that affect the transport, transformation, and deposition of atmospheric pollutants (Byun and Ching, 1999) and explicitly accounts for the formation of secondary ... Leksell and Rabl (2001) for China Note that the China coefficient shown in Leksell and Rabl (2001) is for age 35 and above However, using the same coefficient for the study population age 30 and above ... conduct CMAQ simulations for 3–18 of January, April, July and October 2000 and 2020 using the same meteorology for both years The first days of each month are used as model spin-up and are discarded...

Ngày tải lên: 15/03/2014, 20:20

... mitotic index (MI) and normal and abnormal metaphases of human brain cancer and B-lymphoid cells treated for 24 h with Ruta 6-high dose only, H2O2 only and in combination: A, human MGR1 brain cancer ... death in human (HL-60 and MGR1 glioma) and murine (K 1735 clone X-21) cancer cells and provide chemo-protection for normal human PBLs and B-lymphoid cells, by inducing mitotic catastrophe and erosion ... India The other two authors (S.P and A.S.M.) have performed in vitro experiments to study the effects of Ruta and Ca3(PO4)2 on human and murine cancer cells and normal human peripheral blood lymphocytes...

Ngày tải lên: 22/03/2014, 17:20

... human brain tissues There were 10 peptides showed weak cross-reactivity with human brain tissues and there were peptides showed no cross-reactivity with human brain tissues Sera of patients and ... health human brain tissues (Fig 1), which suggested that a potential cross-reactivity of EV71 with human brain tissues To identify the fragments of EV71 that induce cross-reactivity to human brain ... human adult and fetus brain tissues, respectively (Fig 3) The anti-sera of P230-323, P646-755, P857-1012 and P1329-1440 showed strong staining with neuron plasma in both adult human cerebra and...

Ngày tải lên: 12/08/2014, 04:21

... metabolism-relevant ligands Click here data file bio-ligands Ligands and theand2 of bio-ligands and binding ATP, ligands Additionalfor file 1ownerships of metabolism-relevantADP and block numbers of for proteins ... molecules; Ligands, sc-PDB-derived ligands; Ligands (≤ 3), ligands covering ≤ folds; Ligands (4-9), ligands covering 4-9 folds; Ligands (≥ 10), ligands covering ≥ 10 folds Implications for tracing ... LIGAND: chemical database for enzyme reactions Bioinformatics 1998, 14:591-599 Shin JM, Cho DH: PDB-Ligand: a ligand database based on PDB for the automated and customized classification of ligandbinding...

Ngày tải lên: 14/08/2014, 08:20

... Wenyun and Dr Liu Huixia for useful discussion with them during my study I feel a deep sense of gratitude for my husband Fanwen, for his love, thoughtfulness and patience during the PhD period and ... setting and details for data generation 72 Simulation results for QTL mapping 78 A new algorithm for logistic model with grouped variables 82 4.4.1 Penalized logistic model ... PSR and FDR of various TDTs with FDRC for disease gene mapping 77 4.4 PSR and FDR of logistic regression cum BIC and EBIC for disease gene mapping 78 4.5 PSR and...

Ngày tải lên: 11/09/2015, 16:06

... al., 1994; Hakk and Letcher, 2003) 2.3 2.3.1 Human Exposure to POPs Exposure pathways The exposure pathways to POPs for humans include food and water intake, dermal absorption, and inhalation ... neurocognitive deficits, and hormonal dysfunctions (Rogan et al., 1986; Jacobson et al., 1990; Jacobson and Jacobson, 1996; Berkowitz et al., 2004) The developing brain and nervous system in the ... al (1997), who reported the DDT levels in blood serum were 2.9 ppb for males and 1.5 ppb for females, and 8.1 ppb and 13.4 ppb for DDE respectively These levels were lower than those in countries...

Ngày tải lên: 14/09/2015, 14:06

... represents potential living standard and the wealth of nations more and more closely GDP even includes the share of income which belongs to foreigners living in and working for the host countries while ... Source: Barro and Lee (2011) estimates based on UNESCO Institute for Statistics data on education attainment (2012) and Barro and Lee (2010) methodology Conclusions and policy implications 3.1 ... Southeast Asian region and China Therefore, in order to reduce the gap between GNI (Gross National Income) and GDP (Gross Domestic Product) and to increase mean years and expected years of schooling...

Ngày tải lên: 20/06/2016, 11:24

... short and long-term signalling in normal cardiovascular physiology and disease Short-term signalling is involved in acute and instantaneous regulation functions such as cardiac contractile function ... transients and Ó FEBS 2002 4720 N Dzimiri (Eur J Biochem 269) Table The major human cardiac receptors and their circulatory function- related signalling products The table summarizes the circulatory functionrelated ... cardiac growth and function [5,6] cGMP-dependent PKG inhibition of VEGF synthesis and function [5,6] IK conductance activation; reduction in neuronal ICa; AC inhibition [9,80] essential for proliferation...

Ngày tải lên: 21/02/2014, 15:20

... various systems comprised 3899 and 4516 SPC molecules for the agonist and the antagonist in water, respectively, and 817 and 927 Me2SO molecules for the agonist and the antagonist, respectively, ... alignment illustrated in Fig reveals that Arg78 and Asp81 are present in all forms of MBP and are thus probably essential for the structure and function of MBP As previously reported, aspartic ... the P4, P6 and P9 anchoring pockets [N62a/N62a, Y13b/F11b (F11b points towards Y13b superimposed on DR2 and I-Au) and Y26b/Y26b form the P4 pockets; N62a/N62a, V65a/T65a and Y13b/F11b form the...

Ngày tải lên: 07/03/2014, 16:20

... yÞ=ðyF À yU Þ ð2Þ where yF and yU are the CD signals at 222 nm for the initial and final forms of the protein, respectively [32] and y is the signal of the sample Samples for all CD experiments were ... (http://pymol.sourceforge.net) The G376E and G157D mutations in yeast enolase 10 11 Acknowledgements We thank P Ulycznyj (Concordia Centre for Structural and Functional Genomics) for running many ... a glutamate or aspartate; and (b) silent mutations were introduced that produced new restriction sites These sites, BglII for G376E and AhaIII for G157D, were used for screening purposes following...

Ngày tải lên: 16/03/2014, 06:20

... analysis was performed according to the approach established by Wishart et al [28,29] and shift differences between the Ha-protons of the human/ rat CRH analogue and their values for coil conformation ... shift index, 3JHNHa, and u vs w plots, Fig S2) imply a conformational preference for an extended structure The unambiguous conformational preference for helical structure for the C-terminal 10-peptide ... direction and are relatively close The Oe1 and Oe2 atoms of Glu20 are 3.726 ˚ and 1.983 A, respectively, from the imine He proton and ˚ 3.644 and 5.121 A from the proximal guanidyl Hg11 and Hg12...

Ngày tải lên: 17/03/2014, 10:20

... uniformly hard-working and would happily toil through the day and night in factories making clothing, shoes, appliances and electronics Government needed only to woo investment - most of it foreign ... multinationals and spawned globally competitive, but small-scale local businesses to provide components and contract manufacturing and support services: anything from making models for toy moulds ... competition, some firms will fail and others will flourish and grow in size and their structures become part of internationalized (and sometimes globalized) firm-firm networks and are embedded in international...

Ngày tải lên: 22/03/2014, 13:20

... Association of related and unrelated physical performance tests with self-reported physical function in multivariate models* Self-Reported Physical Function Model Model Model Rise from Chair Get ... perform Hip and knee flexion were scored similarly For analysis, results on the lock and key test were categorized into quartiles, and range of motion of the shoulders Louie and Ward Health and ... this article as: Louie and Ward: Association of measured physical performance and demographic and health characteristics with selfreported physical function: implications for the interpretation...

Ngày tải lên: 20/06/2014, 16:20

... Real-Time Model- Based Human Motion Tracking and Analysis 1659 2D model projection image RUL θXN Foreground image RLL θXRH (a) (b) 2D model projection image 2D model projection image Foreground image Foreground ... 2D model projection image Foreground image Foreground image (a) (b) Figure 9: Shift the 2D model image along (a) X-axis and (b) Y -axis 2D model projection image Foreground image RUA θZN A 2D model ... Markov model (HMM) has also been widely used to model the spatiotemporal property of human motion For instance, it can be applied for recognizing model human dynamics [21], analyzing the human...

Ngày tải lên: 23/06/2014, 01:20

... structure function models is primarily aimed at understanding tree growth and development Functional-structural tree models generally have to represent several processes and to account for the ... Jarvis model for 480 H Sinoquet and X Le Roux instance Aphalo and Jarvis [2] concluded that this model is useful for describing changes in intercellular CO2 concentration and can be used as a submodel ... structuralfunctional tree models, but see the modelling framework proposed by Jones and Sutherland [69]) The first approach does not link stomatal conductance and photosynthesis, while the second and...

Ngày tải lên: 08/08/2014, 14:22

... bone marrow (37-fold increase for IL-1 treatment and 8-fold increase for TNF-α treatment relative to vehicle), dermal (14fold and 4-fold increase) and synovial (31-fold and 7-fold) fibroblasts (Figure ... probe and 25–50 ng cDNA Target genes probes were labelled with FAM and 18S probes were labelled with VIC Reactions occurred as follows: 50°C for minutes, 95°C for 10 minutes, 44 cycles of 95°C for ... of 10 (page number not for citation purposes) Figure Autocrine activation of cortisol and the regulation of fibroblast function of fibroblast function Bone marrow, dermal and synovial fibroblasts...

Ngày tải lên: 09/08/2014, 08:22