Uncovering functional mechanisms in cancer through integrative genomics

... filtering for narrowing down candidates Studies that rely on this principle of genomic and transcriptomic integration are generating new insights into mechanisms of human diseases including cancer ... we designated the staining index of 6-9 as the ―normal‖ baseline expression of THY1 Accordingly, a staining index of 1-4 was considered as reduced expression, and a staining index of was con...

Ngày tải lên: 11/09/2015, 09:05

... University Results Immunostaining Trip10 is differentially methylated in human cancer cell lines and primary tumor specimens Cells were fixed in 2% formaldehyde in phosphate buffered saline (PBS) and ... Overexpression of Trip10 in IMR-32 cells caused Trip10 and huntingtin to colocalize and form perinuclear foci In contrast, while overexpression of Trip10 in...

Ngày tải lên: 10/08/2014, 05:21

... not for citation purposes) Theoretical Biology and Medical Modelling 2008, 5:21 Feature Y Probability Profile Feature Y Probability Profile Feature Y Probability Profile Feature Y Probability Profile ... significantly in their scope and methodology HMMs are for instance quite constrained in that they require sequentiality (making them particularly interesti...

Ngày tải lên: 13/08/2014, 16:21

... X-box-regulated /ciliary genes Many, or even the majority, of these candidate ciliary genes when mutated may cause a dye filling defect Since the majority (83 out of 93) of the candidate X-box-regulated genes ... of bona fide Xbox regulated genes in C elegans In fact, there are still seven dyf genes (dyf-4, dyf-7, dyf-8, dyf-9, dyf-10, dyf-11 and dyf12) in C el...

Ngày tải lên: 14/08/2014, 17:22

... sechellia and D mauritiana) In that study, we also inferred that retroposed copies of Cervantes also originated in the lineages leading to D yakuba and D erecta and this occurred independently in ... our final dataset listed in Additional data file Additional data files The following additional data are available with the online version of this paper Additional data file is...

Ngày tải lên: 14/08/2014, 17:22

... consist of an extracellular domain that contains a ligand-binding site, a transmembrane helix and a cytoplasmic domain The cytoplasmic domain contains a kinase active site that catalyzes tyrosine ... that the SH3 domain of ABL1 is able to participate in intramolecular interactions to inhibit ABL1’s kinase activity9 Apart from intramolecular interactions, the kinase a...

Ngày tải lên: 10/09/2015, 09:04

... genes involved in collagen binding, including several isoforms of collagen; 3) Basal epithelial cell type/ERbreast cancer: Keratin 5, Keratin 17, and SFRP1 Keratin has been used a marker to stain ... Studies of Cancer Genomics 13 2.1 Cancer 13 2.2 microarray Application in Cancer Research 15 2.3 Novel data analysis methods to refine the molecular profiling of cancer ... the...

Ngày tải lên: 11/09/2015, 09:04

... precision of therapy like the intensity-modulated radiation therapy (IMRT) and the use of heavy ions demands absolute reliability of new diagnostics and treatment planning for prostate and brain ... 14 It was used to investigate whether an intracellular MR imaging is possible and to estimate the T1 relaxivity on MR (1.5 T) Historically already in 1994 electron-spin-resonance...

Ngày tải lên: 26/10/2012, 09:07

... receptor tyrosine kinase activity [4], and the finding of EGFR, the first receptor tyrosine kinase paved the way to the understanding of the role and significance of tyrosine kinase in cancer ... tyrosine kinase inhibitors Inhibiting the activity of tyrosine kinases by low molecular weight compounds capable of interfering with either ligand binding (in the case of receptor...

Ngày tải lên: 03/11/2012, 09:57

... obviously information of some kind The item ‘information’ underlined in the last paragraph, therefore, can be interpreted as a general superordinate of whatever information appears before That is ... falling into the topic statement is relatively great (8/14 =) This fact results from the chief intended purpose of the lead: to restate in more details the main idea introduced in the headl...

Ngày tải lên: 19/12/2013, 15:02

... the elderly Maintaining function is central to fostering health and independence in the hospitalized elderly • The hospitalized elderly are at risk for decreased mobility and functional decline ... hospitalizations in the elderly Functional Decline During Hospitalization During hospitalization, the elderly patient often experiences reduced mobility and activity level...

Ngày tải lên: 14/02/2014, 07:20

... cavity and pharynx) cancer, ovarian cancer, pancreas cancer, prostate cancer, stomach cancer, thyroid cancer, and urinary bladder cancer To compare incidence rates in the poverty area groups, incidence ... New Jersey on January 1, 2003; and • Childhood Cancer in New Jersey 1979-2002 Our new interactive cancer data mapping application provides incidence and...

Ngày tải lên: 14/02/2014, 21:20

... Diagnosis and Genetic Testing and Molecular Biomarkers BIOMARKERS IN CANCER: AN INTRODUCTORY GUIDE FOR ADVOCATES Biomarkers and Individualized Medicine A major reason for the increasing interest in biomarkers ... BIOMARKERS IN CANCER: AN INTRODUCTORY GUIDE FOR ADVOCATES 28 BIOMARKERS IN CANCER: AN INTRODUCTORY GUIDE FOR ADVOCATES 29 CH...

Ngày tải lên: 14/02/2014, 21:20

... Additional Methodological Issues in Cancer CAM Research Multidisciplinary Approaches in Cancer Treatment Investigators are often interested in investigating multidisciplinary approaches in cancer care ... the Indian subcontinent including, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam Assurance, Institutional Assurance...

Ngày tải lên: 14/02/2014, 22:20