Characterisation of lung dendritic cell function in a mouse model of influenza

... resulting in intracellular ionic imbalance and activation of the inflammasome (Ichinohe et al 2010) Although influenza infection results in activation of the inflammasome in both lung stromal and ... ciliated epithelium results in initial shrinkage and vacuolaization of the cells, culminating in necrosis and eventual desquamation of these cells into the luminal space The...

Ngày tải lên: 10/09/2015, 15:53

... (s.e.m.) After log transformation, airway responsiveness to methacholine was statistically analyzed by a general linear model of repeated measurements (ANOVA) followed by a post hoc comparison ... characterized by AHR, induction of specific IgE and airway eosinophilia We show for the first time that AHR is dramatically increased by GITR triggering at the time of alle...

Ngày tải lên: 12/08/2014, 14:20

... with both the avian and human strains of influenza This facilitates viral reassortment and the generation of novel   10 Chapter 1: Introduction human viral strains with the potential of transferring ... cells HAspecific antibodies form a solid correlate of protection against influenza provided that they match the virus causing the infection In contrast to the antib...

Ngày tải lên: 10/09/2015, 09:25

... Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S: Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil ... cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscri...

Ngày tải lên: 18/06/2014, 22:20

... Homma Y, Kawakami Y: Enhancement of goblet cell hyperplasia and airway hyperresponsiveness by salbutamol in a rat model of atopic asthma Thorax 2001, 56:19-24 30 Tamaoki J, Tagaya E, Kawatani ... Efficacy of inhaled corticosteroids in asthma The Journal of allergy and clinical immunology 1998, 102:531-538 29 Kamachi A, Munakata M, Nasuhara Y, Nishimura M, Ohtsuka Y, Ami...

Ngày tải lên: 12/08/2014, 11:20

... et al.: Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma Respiratory Research 2010 11:138 Submit your next manuscript ... function and airway inflammation caused by a potent oxidant like Cl2 is relatively under-investigated Recently a combination of anti-oxidants (ascorbic acid,...

Ngày tải lên: 12/08/2014, 11:22

... delineated role of PIMs by comparing LPS-induced lung inflammation and mortality in BDL rats and GCtreated BDL rats The dramatic finding was 100% and 80% survival in BDL rats that were treated with ... AC: Quantitation of eosinophil and neutrophil infiltration into rat lung by specific assays for eosinophil peroxidase and myeloperoxidase Application in a Brow...

Ngày tải lên: 12/08/2014, 14:20

... peptides including LANP, VD and KP in modulating lung inflammation In this report we show that overexpression of VD attenuates airway inflammation in a mouse model of allergic asthma The effects of ... determine airway resistance values and peak values obtained after each MeCh challenge were plotted [16] Modulation of lung inflammation by VD To test the eff...

Ngày tải lên: 12/08/2014, 14:20

... data confirmed that Wlds reactivates dormant cell cycle pathways, pushing cells toward cell cycle re-entry rather than inhibiting it Role of Pttg1, NAD, and VCP pathways in mediating cell cycle ... SuperArray analysis as being upregulated by more than twofold The final portion of the graph shows similar increases in cell cycle proteins not included on the SuperArray pl...

Ngày tải lên: 14/08/2014, 20:22

... [7], although kinetic studies [8] indicate that its alanineglyoxylate aminotransferase activity is not favored over aminobutyrate-pyruvate, b-alanine-pyruvate and dimethylarginine-pyruvate aminotransferase ... (p97) cofactor (p47) Aminoacylase Phosphoglycerate mutase Indolethylamine N-methyltransferase Peroxiredoxin Apolipoprotein A- I Abhydrolase domain containing 14b D-Amino Protein na...

Ngày tải lên: 23/03/2014, 03:20

... survival data we also analyzed the animals' clinical status We found that imatinib treatment in both early and late treatment arms also attenuated radiationrelated clinical adverse effects such as ... imatinib treatment starting days and weeks after radiation (RT) Fibrosis is characterized by diffuse bilateral areas of "ground-glass" attenuation and intralobular reticular opac...

Ngày tải lên: 09/08/2014, 10:20

... of adenomatous polyposis coli (APC), somatostatin, carbonic anhydrase and tenascin C in the cerebellum (Figure 1a) and those of lysyl oxidase, carbonic anhydrase 4, enolase 3β and creatine kinase ... sensitive to thyroid hormone and the primary mode of T3 action is a direct influence on cardiac gene expression [20] Increased heart rate (tachycardia) and myocardial contractility...

Ngày tải lên: 09/08/2014, 20:20

... microarray analysis Additional data file is a table listing highly ranked retinal miR target genes predicted using miRanda The miRNA array data are available at Array Express [58] using accession ... version of this paper Additional data file is a table listing retinal miR expression data from Exiqon microarray analysis Additional data file is a table listing retinal miR expr...

Ngày tải lên: 14/08/2014, 08:20

... anhydrases CA I and CA IV and aquaporins Aqp4 and Aqp8 [78-80] These results indicate that infectious diarrhea and noninfectious inflammationassociated diarrhea may have common mechanisms of pathogenesis ... adult mouse gastrointestinal tract identified by microarray analysis Gastroenterology 2002, 122:1467-1482 Bekku S, Mochizuki H, Takayama E, Shinomiya N, Fukamachi H, Ichinose M, Tad...

Ngày tải lên: 14/08/2014, 20:22