Developing peptide based approaches for systematic enzyme profiling

... microarray -based enzyme assays capable of sensitive detection of different enzyme classes.5 At present, four key microarray -based platforms, namely protein-, peptide- , small-molecule- and cell -based ... SHP2-selective peptides 92 5.5 List of 16 p(CAP) peptides used in the peptide microarray 94 5.6 The summary of microplate assay with p(CAP) peptide against PTPs 95 10.1 List of...

Ngày tải lên: 10/09/2015, 15:49

... Hu, Y., Uttamchandani, M., Yao, S Q “Microarray: A Versatile Platform for High- Throughput Functional Proteomics”, Comb Chem High Throughput Screening 2006, 9, 203-212 Wang, J., Uttamchandani, M., ... proteomics with the aid of the aforementioned highthroughput screening platforms Of specific interest to the context of this thesis are applications that facilitate rapid enzyme prof...

Ngày tải lên: 14/09/2015, 12:41

... Wee Liang for helping me in the synthesis of the NDA-AD cross-linker, Derek for helping me in the synthesis of the dialdehyde and Liquian and Hongyan for their help in the peptide synthesis - ... expression levels of the proteins, relatively newer approaches such as Activity- Based Protein Profiling (ABPP) provide more insights into the functional states of...

Ngày tải lên: 11/09/2015, 09:58

... assess the credit quality of municipal bonds based on whatever information is available to them For example, the MuniCredit Public Power Model ranks public power bonds by degree of credit quality ... schools In municipal bonds, this reasoning style is followed when analysts assess similarities between bonds Neural Networks These models also represent judgments and expertise in th...

Ngày tải lên: 22/03/2014, 18:20

... relatively high metabolic-network modularity This supports the notion previously put forward by Parter et al [13] that variability in the natural habitat of an organism promotes modularity in its ... circuitry Microorganisms constantly monitor their surroundings for the availability of nutrients and other chemicals, using both Genome Biology 2008, 9:239 Genome Biology 2008, http://genomebio...

Ngày tải lên: 14/08/2014, 21:20

... molecule probes for proteomics applications”, Appl Genomics Proteomics, 2003, in press Tan, E.L.P., Panicker, R.C., Tan, L.P., Chattopadhaya, S., Yao, S.Q Developing chemical biology tools for the study ... be analyze by 2D-GE, thereby rendering the technique insufficient for large- scale protein profiling in human 1.2 Addressing the proteomic challenges In this section, two str...

Ngày tải lên: 04/10/2015, 15:45

... overview of applications of high- throughput technologies in chemical proteomics Much attention will be focused on studies of high- throughput strategies for proteomic profiling of aspartic proteases ... Objectives The aim of this thesis is to develop high- throughput amenable strategies for chemically profiling of aspartic proteases as well as protei...

Ngày tải lên: 10/09/2015, 15:49

... They are predicated on the equivalence of one nation-one culture- one language, and on the expectation that a culture shock” may take place upon crossing national boundaries In foreign language ... to raising cross- cultural awareness for the first- year non-major students at National Economics University (2) British and American culture in language u...

Ngày tải lên: 29/01/2014, 10:33

... Viberg, “Two new approaches for channel prediction based on sinusoidal modeling,” EURASIP Journal on Applied Signal Processing, special issue on advances in subspace -based techniques for signal ... performance of the sinusoidal modelingbased channel prediction methods depends heavily on the stationarity properties of model parameters in the observation window a...

Ngày tải lên: 22/06/2014, 23:20

... and health status, use of self-care and self-care support, and a set of validated measures on aspects of social capital and social support A second survey instrument was administered and audio-recorded ... Trusts and the University of Manchester and is part of the National Institute for Health Research The authors are members of the Patient Them...

Ngày tải lên: 10/08/2014, 10:23

... otherwise non-related sequence pair, see [16] for details 2.1 Combining segment-based greedy and progressive alignment To overcome the difficulties of a 'direct' greedy algorithm for multiple alignment, ... L-INSi and E-INSi [21,22] We performed benchmarks for DNA as well as for protein alignment As globally related benchmark sets we used BRAliBase II [36,37] for RNA...

Ngày tải lên: 12/08/2014, 17:20

... score measured in a prespecified time interval, and mean SOFA was always calculated by taking the average of all total SOFA scores in the prespecified time interval These intervals varied in length, ... ICU stay found an AUC of 0.79, which was almost the same as the AUC for a single SOFA-score at admission [17] A high delta SOFA indicates increasing organ dysfunction...

Ngày tải lên: 13/08/2014, 11:23

... Developing social activity competence for students in pedagogic universities in the Northern mountainous area in credit - based training system 3 Purpose of the research Developing social activity ... software Some main scientific points of the thesis 8.1 Developing social activity competence for students in pedagogic universitie...

Ngày tải lên: 26/08/2015, 21:34

... Selection AE -1 50 10 0 15 0 200 250 300 Tool State flank wear tool state 0.5 detected wear=0.307mm 50 10 0 15 0 200 250 300 Tool State flank wear tool state 0.5 detected wear=0.306mm 50 10 0 15 0 Time(s) ... d=2mm) AE -1 50 10 0 15 0 200 250 300 350 Tool State flank wear tool state 0.5 detected wear=0. 312 mm 50 10 0 15 0 200 250 300 350 Tool State flank wear tool...

Ngày tải lên: 16/09/2015, 17:13

... information (condition identification) are fully integrated Signal Selection and Acquisition Information Processing and Refinement Decision Making Tool Condition Figure 1.1 Information flow and ... Evaluation of the severity of certain abnormal tool conditions Prediction of tool conditions and control of machining process This research focuses on the first item, i.e binary tool c...

Ngày tải lên: 16/09/2015, 17:13