Developing high throughput chemical approaches for proteomic profiling of aspartic proteases and protein kinases

Developing high throughput chemical approaches for proteomic profiling of aspartic proteases and protein kinases

Ngày tải lên : 10/09/2015, 15:49
... the order of the steps also differs for different kinases For example, some kinases bind to their protein substrates before binding ATP and others release ADP before releasing the protein substrate.19 ... Building Blocks 170 8.3.4 Procedure for Synthesis of the 198-member N-terminal Library 173 8.3.5 8.4 Procedure for Synthesis of the Diol Library Procedure for Synthesis of the 100-member C-terminal ... challenges by combination of various synthetic approaches and introducing high throughput screening platforms Chapter describes a solution-cum-solid phase strategy for rapid assembly of diol-containing...
305 174 0
Developing peptide based approaches for systematic enzyme profiling

Developing peptide based approaches for systematic enzyme profiling

Ngày tải lên : 10/09/2015, 15:49
... Fingerprinting of Seven 14-3-3 Isoforms 66 4.3.3 Identification of Isoform-Specific Binding Motif for 14-3-3 Sigma 4.4 Conclusion Chapter Peptide Microarray for Studying PTPs 73 76 77 iv 5.1 ... including fluorogenic or chromogenic substrates, FRET substrates or sensors for product information, for instance, pH indicators for ester hydrolyses.7 Such assays are also highly sensitive since they ... screen for LEP inhibitors like Na-tosyl-lysine chloromethylketone (TLCK), the authors showed that FRET-based protease assays are 28 also suitable in a microarray format, and therefore may be used for...
212 257 0
Developing chemical biology approaches for the activity based investigations of reversible protein phosphorylation mediating enzymes

Developing chemical biology approaches for the activity based investigations of reversible protein phosphorylation mediating enzymes

Ngày tải lên : 11/09/2015, 09:58
... thank Raja for introducing me to the Chemistry lab, for showing me for the first time how to run a column, for all your support at every stage of my life in the lab I thank Souvik for all his ... Liu Kai for providing me all the kinases, for the PTP-pull-down experiments and for all the biological experiments with the NDA-AD cross-linker Lay Pheng for providing me all the PTPs and for helping ... least I thank the NUS for financial support in the form of the research scholarship iii      Table of Contents Contents Chapter 1: Introduction Page 1 Proteomic approaches for the global analysis...
224 346 0
Best Practices for Developing a Web Site

Best Practices for Developing a Web Site

Ngày tải lên : 20/08/2012, 11:43
... Practices for Developing a Web Site, an Internet.com Project Management eBook © 2008, Jupitermedia Corp [ Best Practices for Developing a Web Site Brands are used to promote a business in various forms ... done in the past before you sign a contract Best Practices for Developing a Web Site, an Internet.com Project Management eBook © 2008, Jupitermedia Corp [ Best Practices for Developing a Web Site ... technology and charge you extra for the source Best Practices for Developing a Web Site, an Internet.com Project Management eBook © 2008, Jupitermedia Corp [ Best Practices for Developing a Web Site ]...
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Techniques for developing content reading skills for the third year students at the university of odonto and stomatology

Techniques for developing content reading skills for the third year students at the university of odonto and stomatology

Ngày tải lên : 07/11/2012, 14:50
... new vocabulary before reading, and asking students to perform tasks that are within their competence, such as skimming to get the main idea or scanning for specific information, before they begin ... ESP teachers to integrate different useful approaches for more interesting lessons These approaches will be mentioned latter in terms of techniques for improving content reading skills To sum ... information technology in their learning but the teachers find it time and effort consuming From this result, it is time for the teachers to take advantages of visual aids in teaching reading for...
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TECHNIQUES FOR DEVELOPING CONTENT READING SKILLS FOR THE THIRD YEAR STUDENTS AT THE UNIVERSITY OF ODONTO AND STOMATOLOGY

TECHNIQUES FOR DEVELOPING CONTENT READING SKILLS FOR THE THIRD YEAR STUDENTS AT THE UNIVERSITY OF ODONTO AND STOMATOLOGY

Ngày tải lên : 07/09/2013, 13:45
... a sample work for some reading lessons for 3rd year students Part III summarizes the issues addressed and presents recommendations for further improvements and some suggestions for further researches ... ESP teachers to integrate different useful approaches for more interesting lessons These approaches will be mentioned latter in terms of techniques for improving content reading skills To sum ... reading short texts to extract specific information This is an accuracy activity involving reading for details” (Grellet,1981:41) It requires readers when performing reading process to understand...
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Tài liệu The and Social EffEconomic ects of Financial Liberalization: A Primer for Developing Countries pdf

Tài liệu The and Social EffEconomic ects of Financial Liberalization: A Primer for Developing Countries pdf

Ngày tải lên : 23/12/2013, 13:15
... Social Effects of Financial Liberalization: A Primer for Developing Countries1 Jayati Ghosh For more than a decade now, financial liberalization in developing countries has been cited as a necessary ... attractive, even after adjusting for risk Trade and financial liberalization in developing countries would not have been sustainable, even for short periods, had it not been for the availability of fluid ... of developed countries and are insufficiently flexible for developing countries (GriffithJones and Ocampo, 2004) So, there is a strong case for developing countries to ensure that their own financial...
20 482 0
Tài liệu Guidelines for Developing Traffic Safety Educational Materials for Spanish-Speaking Audiences doc

Tài liệu Guidelines for Developing Traffic Safety Educational Materials for Spanish-Speaking Audiences doc

Ngày tải lên : 16/01/2014, 22:20
... material is hard for them to understand For example, comfort padding, the English technical term that describes the padding in a helmet, is translated into Spanish as acojinado de confort, but ... item for their audience and how to modify for their particular community materials that were developed for a broader audience -- Critical Expertise You Need Developing an effective material for ... larger intervention or as a standalone effort) Certain communication approaches and formats are especially effective for audiences with low literacy Information about these practices is available...
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Tài liệu The Economic and Social Effects of Financial Liberalization: A Primer for Developing Countries pptx

Tài liệu The Economic and Social Effects of Financial Liberalization: A Primer for Developing Countries pptx

Ngày tải lên : 20/01/2014, 19:20
... v= ka 12 Slide #14-12 Cấu trúc tài (Q (Quản trò tài chính) ò ) – Trong đo: đó: EBIT (Earnings before interest and taxes) T : Ta es Taxes EBIT x (1- T)= Lợi nhuận sau thuế nợ vàø vốán cổå phầàn ... Corporate bond Commercial paper C i l Nguồn tài trợ Mỹ 1970-1985 Government loans loans b f i l by foreigners Trade debt Copyright © 2000 Addison Wesley Longman Slide #14-18 Nguồn tài trợ nước phát...
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Tài liệu Creating a Sustainable Organization: Approaches for Enhancing Corporate Value Through Sustainability pdf

Tài liệu Creating a Sustainable Organization: Approaches for Enhancing Corporate Value Through Sustainability pdf

Ngày tải lên : 19/02/2014, 21:20
... ordered in quantity for bulk purchases or special sales For more information, please contact U.S Corporate and Government Sales, 1-800-382-3419, corpsales@pearsontechgroup.com For sales outside ... Goodman, and many others within my professional circle for their support in developing my idea for a book and helping it take shape xiii Developing a written work of this length and depth is ... implications for professionals in the relevant fields, for corporate leaders, and, in due course, for policymakers, regulators, and the educated general public The book will have particular import for...
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Tài liệu The Global economic crisis challenGes for DevelopinG asia anD aDb’s response ppt

Tài liệu The Global economic crisis challenGes for DevelopinG asia anD aDb’s response ppt

Ngày tải lên : 21/02/2014, 00:20
... dialogue includes the reforms in the global financial architecture to avert crises like the current one Developing Asia’s active participation in global forums for financial reform will ensure that ... solution The Group of Twenty (G20) framework provides a global platform for developing and developed countries to jointly consider approaches to overcoming the crisis.3 In its April London meeting, ... actions and reforms already initiated by DMCs, is discussed in Section III Section IV examines important policy issues the crisis has raised for developing Asia and summarizes the reforms DMCs should...
33 383 0
Tài liệu Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1 doc

Tài liệu Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1 doc

Ngày tải lên : 21/02/2014, 01:20
... into possible alternative approaches for control of AIV in poultry particularly against the HPAI H5N1 subtype Antivirals 2.1 Chemotherapy The use of chemotherapeutic agents for control of AIV in ... real challenge for the scientific community [12] Recently, several approaches to control the disease were developed and have yielded promising results Although beneficial, these approaches face ... alternate approaches might be an aid but should not jeopardize surveillance and current control measures Viruses 2012, 3190 Table Advantages and limitations of different alternative approaches for...
30 545 0
Tài liệu Design for Sustainability a practical approach for Developing Economies doc

Tài liệu Design for Sustainability a practical approach for Developing Economies doc

Ngày tải lên : 21/02/2014, 05:20
... University of Technology publication on Design for Sustainability: a practical approach for developing economies! In this introduction, the relevance of D4S for developing economies is highlighted Next, ... convergent activity These approaches identify relevant information in a creative way and then evaluate it Divergent methods search for ideas and include searching for information, to explore the ... opportunities for SMEs in developing economies are explained For the companies involved in a D4S project it may be the first time they have been involved in a systematic product development process Therefore,...
128 514 0
Air Force Service Procurement - Approaches for Measurement and Management pptx

Air Force Service Procurement - Approaches for Measurement and Management pptx

Ngày tải lên : 06/03/2014, 20:20
... Assistant Secretary for Contracting as part of the effort to transform the procurement workforce for the 21st century (see Ausink, Baldwin, and Paul, 2004) In developing this portfolio for the AFPEO/CM, ... entitled “Supporting Air Force Procurement Transformation and Laying the Groundwork for Services Acquisition Reform,” sponsored by the Air Force Deputy Assistant Secretary for Contracting and conducted ... MacLean (2002) for a discussion of supply base “rationalization.” 14 Air Force Service Procurement: Approaches for Measurement and Management Figure 2.1 represents one ideal for developing purchasing...
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Business Process Analysis Worksheets and Guidelines: Procedures for Developing Business Processes in ebXML v1.0 docx

Business Process Analysis Worksheets and Guidelines: Procedures for Developing Business Processes in ebXML v1.0 docx

Ngày tải lên : 06/03/2014, 20:21
... Description forms, then a set of Content Mapping forms should be completed for that schema (the component names in the forms are simply requirements for information) For each Content Description form, ... be significantly harder to up front!) The recommended format is: -- Where is BRM for Business Reference Model BA for Business Area PA for Business Process ... Collaboration Protocol Table BT for Business Transaction BTTT for Business Transaction Transition Table BIC for Business Information Context CD for Content Description CM for Content Mapping There...
99 562 0
Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot

Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot

Ngày tải lên : 07/03/2014, 10:20
... promote formation of neurofibrillary tangles [7] Both fibrillar Ab and PrPSc are capable of forming amyloid deposits The presence of amyloid deposits is necessary for making the diagnosis CONFORMATIONAL ... inherited forms of CJD are the result of a point mutation in PrPC that increases the propensity for it to assume an abnormal conformation Virtually all genetic defects implicated in familial forms ... 872–881 Sadowski M & Wisniewski T (2004) Vaccines for conformational disorders Exp Rev Vaccines 3, 89–100 Sigurdsson EM (2006) Immunotherapy for conformational disorders Curr Pharm Des 12, 2569–2585...
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Báo cáo khoa học: "A Re-examination of Machine Learning Approaches for Sentence-Level MT Evaluation" ppt

Báo cáo khoa học: "A Re-examination of Machine Learning Approaches for Sentence-Level MT Evaluation" ppt

Ngày tải lên : 08/03/2014, 02:21
... (Liu and Gildea, 2006) in that word class information is used Finally, researchers have begun to look for similarities at a deeper structural level For example, Liu and Gildea (2005) developed ... assessment data are an invaluable resource for measuring the reliability of automatic evaluation metrics In this paper, we show that they are also informative in developing better metrics MT Evaluation ... training examples for classifiers are not entirely free: human reference translations still must be developed for the source sentences Figure 2(c) shows the learning curves for training Human-Likeness...
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optimisation of selective breeding program for nile tilapia (oreochromis niloticus)

optimisation of selective breeding program for nile tilapia (oreochromis niloticus)

Ngày tải lên : 13/03/2014, 18:58
... al., 2010b) The breeding scheme of the GIFT project is based on Best Linear Unbiased Prediction (BLUP) breeding value estimation using individual information (own performance) and information from ... properly corrected for On the other hand, DGC accounts for only the growth period, therefore allows more accurate estimates of G×E In Nile tilapia, various estimates for G×E for harvest weight ... for candidate dams and from 3.7 to 14.8% for candidate sires (Table 2.1) For example, in R1 cohort offspring–cohort parent assignment, the missing proportions were 14.8% for sires and 14.9% for...
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Health-promoting schools: a resource for developing indicators doc

Health-promoting schools: a resource for developing indicators doc

Ngày tải lên : 14/03/2014, 20:20
... working for WHO She is responsible for the Technical Secretariat for the European Network of Health Promoting Schools The Technical Secretariat supports countries throughout Europe in developing ... Kiaer and Jane Persson for their great efforts in producing this book We thank Beat Hess of Switzerland’s Federal Office of Public Health for his long-standing support for the European Network ... seeking to develop formal signed agreements that set out a programme or strategy for joint work This has proved a practical resource for enabling a degree of sustainability for the development...
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