Synthesis and structure investigation of stabilized aromatic oligoamides and their interaction with g quadruplex structures 3

... 161. 13, 155 .38 , 155.08, 149.09, 147. 43, 147 .39 , 147.19, 147.09, 144.42, 1 43. 95, 140. 53, 132 .91, 132 . 53, 132 .36 , 132 .28, 132 .21, 132 . 13, 129 .39 , 126.91, 126. 83, 126.69, 126.52, 126.45, 125. 63, 125.45, ... 4.00 (s, 3H), 3. 94 (s, 3H), 3. 90 (s, 6H), 3. 83 (s, 3H), 3. 82 (s, 3H), 1.67 (m, 2H), 1.48 (s, 6H), 1.27 (m, 8H), 1.15 (m, 2H), 0.66 (m, 3H) 13C NMR (125 MHz, CDC...

Ngày tải lên: 10/09/2015, 15:49

... the group of Hamilton,29 Lehn,28 Gong ,13 Huc15 and Li16 made a great contribution in developing crescent and helical structures containing cavtities with tunable sizes since 19 99 Gong’s group ... pore was prompted as 10 Figure 1. 7b.24 Figure 1. 7 Circular aromatic oligoamides from Gong’s group (a) Chemical structures of shape persistent macrocyles 1, (b) with thei...

Ngày tải lên: 10/09/2015, 15:49

... 126 .55， 126 .47, 126 .36, 126 .31, 126 .18， 126 .03, 125 .97, 125 . 92, 125 .84, 125 .35, 125 .13, 63 124 .99, 124 .88, 124 .84, 124 .68, 124 .43, 123 .10, 64.46, 63 .26 , 63.10, 63.00, 62. 97, 62. 25, 52. 23 HRMS-ESI: ... 131.97, 129 .09, 128 .97, 126 .73, 126 .63, 126 .22 , 125 .79, 125 .05, 124 .71, 124 .59, 124 . 42, 123 .45, 64.45, 63 .23 , 62. 50, 53.38, 52. 30 HRMS-ESI: calculated f...

Ngày tải lên: 10/09/2015, 15:49

... H-bonding interactions, leading to the rigidification of the amide linkages and a crescent aromatic backbone Figure 4. 2 1H NMR spectrum (500 MHz, 298 K, CDCl3) of pentamer at mM 4. 2 .4 Solid State Structure ... 165.83, 163.13, 160 .41 , 159 .44 , 156. 14, 155.30, 1 54. 23, 152.13, 151.56, 149 .60, 141 .79, 139 .47 , 138.29, 137. 54, 1 24 136 .47 , 1 34. 80, 133.90, 132.79, 129...

Ngày tải lên: 10/09/2015, 15:49

... forming a parallel G- quadruplex ODN4 5 -GAGTTAGAGTTAGAGTTAGAGT-3’ Mutated ODN1 that can’t form a G- quadruplex ODN5 5 -AGGGTTAGGGTTAGGGTTAGGGT-3’ Telomeric DNA forming -parallel/antiparallel G- quadruplex ... DNA forming -parallel/antiparallel G- quadruplex in K ODN2 5 -TAGGGTTAGGGTTAGGGTTAGGGT-3’ Telomeric DNA mixed + forming mixed -parallel/antiparallel G- quadruplex in K...

Ngày tải lên: 10/09/2015, 15:49

... TBA 5’- GGTTGGTGT GGTTGG-3’ Thrombin-binding aptamer TBA2 5’-AGTCCGTGGTAGGGCAGGTTGGGGTGACT-3’ Thrombin-binding aptamer Apt29R 5’- AGTCACCCCAACCTGCCCTACCACGGACT-3’ Complementary sequence of TBA2 ... (5’-GGTTGGTGTGGTTGG-3’), which binds to the fibrinogen-binding site of thrombin with Kd ≈ 100 nM, and (5’-AGTCCGTGGTAGGGCAGGTTGGGGTGACT-3’), heparin-binding site of thrombin with Kd ≈ 0...

Ngày tải lên: 10/09/2015, 15:49

... AuNPs aggregation was studied As in Figure 7. 5, even though the aggregation of gold nanoparticles remained when the concentration of 10a is lower than μM, at 0 .75 μM, partial disaggregation of AuNPs ... capable of strong binding toward TBA Thus, the developed AuNPs screening assay allows the efficient and specific identification of G- quadruplex- binding ligands Figure 7. 13...

Ngày tải lên: 10/09/2015, 15:49

... On the other hand, the decreased activity of the RATEs as compared with RNase A ([16] and Table 1) indicate a negative influence of the tandemization on the catalytic efficiency The recovery of activity ... Crystal structure of RNase A tandem enzymes A U Arnold et al B C Fig Alignment of SGRSGRSG-RATE with the RI RNase A complex The crysta...

Ngày tải lên: 22/03/2014, 16:21

... thus, any rarefaction waves arising behind the wave front will overtake and weaken the detonation wave As a matter of fact, a strong detonation, also called overdriven detonation, is not stable and ... For a steady, planar, one-dimensional detonation wave, with both the reactants and products modeled as the same perfect gas and the detonation wave modeled as a di...

Ngày tải lên: 11/09/2015, 16:07

... four kinds of wave modelings to study a prototype wave system, i.e., analytical modeling, empirical modeling, physical modeling and numerical modeling With their inherent advantages and disadvantages, ... technology, numerical modeling becomes more and more popular and important to study water waves A numerical wave model is the combination of mathematical re...

Ngày tải lên: 13/09/2015, 20:56

... vicilins, systemins and enzyme inhibitors [5±8] The enzyme inhibitors act on key insect gut digestive hydrolases, the a-amylases and proteinases Several kinds of a-amylase and proteinase inhibitors, ... digestive a-amylases of guts of locust and cockroach, poorly inhibited a-amylases from A oryzae and human saliva and failed to inhibit the a-amylases from porcine...

Ngày tải lên: 21/02/2014, 03:20

... coefficient of determination 219 Growth Performance and Sperm Quality of Stress Negative Piétrain Boars and Their Hybrids with Duroc Table Production performance, Least square means (LSMSE) of PiDu and ... Growth Performance and Sperm Quality of Stress Negative Piétrain Boars and Their Hybrids with Duroc Kawecka et al (2008),...

Ngày tải lên: 28/08/2013, 11:59

... R S E R I E S N O 12 / d e c e m b e r 2010 AN ANALYSIS OF EURO AREA SOVEREIGN CDS AND THEIR RELATION WITH GOVERNMENT BONDS by Alessandro Fontana and Martin Scheicher NOTE: This Working Paper ... of total bonds outstanding For Greece, the net open CDS amount to around 3% of their outstanding sovereign debt and for Portugal and Ireland around 7% This...

Ngày tải lên: 16/02/2014, 02:20

... replication-dependent variants H1.1–H1.5 and Structure and function of the linker histone variants Location and structure of the linker histones Historically, the location of the globular domain of the linker histone ... overall number of these modifications is low, the density of modifications is much the same as in the rest of the linke...

Ngày tải lên: 18/02/2014, 08:20

... range of conditions The goal of this manuscript is to provide a detailed understanding of the heart as a muscular pump and of the interaction between the heart and the vasculature The concepts of ... Cardiac Physiology Page of 23 MECHANICAL PROPERTIES OF THE HEART AND ITS INTERACTION WITH THE VASCULAR SYSTEM Daniel Burkhoff MD PhD, Ass...

Ngày tải lên: 22/02/2014, 09:20