The role of interferon gamma in regulating antigen specific CD8 t cell responses in a mouse model of influenza

... with both the avian and human strains of influenza This facilitates viral reassortment and the generation of novel   10 Chapter 1: Introduction human viral strains with the potential of transferring ... cells HAspecific antibodies form a solid correlate of protection against influenza provided that they match the virus causing the infection In contrast to the antib...

Ngày tải lên: 10/09/2015, 09:25

... immune assays and to build reagent panels able to accurately characterize the phenotype and function of responding T-cells More importantly, the ICS assay can be used as primary assay to evaluate HIV-1-specific ... increase the simultaneous measurement of cytokines for this kind of assays On the other hand, the introduction of new reagents, instruments and software,...

Ngày tải lên: 10/08/2014, 05:21

... microarray-based approaches to examine gene expression and miRNA changes in the brainstem and prefrontal cortex in a mouse facial carrageenan injection model of orofacial pain At the brainstem level, increased ... Inflammatory pain Tissue injury initiates an inflammatory response that induces pain This type of pain is known as inflammatory pain...

Ngày tải lên: 10/09/2015, 08:34

... TGF-β1 in the urine of male rats after CYP were also significantly higher than the levels of active and total TGF-β1 in the urine of female rats, both at baseline and after CYP (ANOVA, Tukey post ... control rats collected at the same time point of the day The levels of NO2-/NO3- in the urine of CYP-treated female rats remained higher as compared to both CY...

Ngày tải lên: 11/08/2014, 08:22

... 5'-GAACAACATGCATTCCGAGAAG-3' Forward: 5'-GCGCAGCGCGTTGAA-3' Probe: 5'-AACGAACAGTCATCACCACATCTCATCCAG-3' Reverse: 5'-GGATGGAGCTCGTCCAAGTG-3' Forward: 5'-GCCATCCTGACTATTTCACTGAAGA-3' Probe: 5'-AAGCCTACTTTTTCTCAAGGGCAGTCACCG-3' ... was therefore used as an internal control Statistical analysis All statistical analyses were done using StatView software (SAS Institute Inc., Cary, NC, USA) Data wer...

Ngày tải lên: 13/08/2014, 19:20

... TRANSPLANTATION OF MESENCHYMAL STEM CELLS FOR THE TREATMENT OF PARKINSON’S DISEASE IN A MOUSE MODEL CHAO YIN XIA MD A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ANATOMY ... MPTP, an acute insult initiates an inflammatory reaction that becomes self sustaining after the initiating agent has disappeared The MPTP model of...

Ngày tải lên: 11/09/2015, 09:05

... complicated because of the region’s density of anatomical structures, rich innervations and high vascularity Orofacial pain is defined by the American Academy of Orofacial Pain (AAOP) as pain conditions ... as brushing and touch, are painful (allodynia), and normally mild pain stimuli like pinprick are much more painful than usual (hyperalgesia) Hyperalgesia in the ar...

Ngày tải lên: 14/09/2015, 08:42

... GENE EXPRESSION CHANGES IN THE BRAINSTEM IN A MOUSE MODEL OF OROFACIAL PAIN DR LUTFUN NAHAR NATIONAL UNIVERSITY OF SINGAPORE 2009 II GENE EXPRESSION CHANGES IN THE BRAINSTEM IN A MOUSE MODEL ... neuron in the sensory ganglion of cranial nerves VII, IX and X OROFACIAL PAIN The diagnosis and treatment of facial pain remains a gre...

Ngày tải lên: 07/10/2015, 09:55

... [7], although kinetic studies [8] indicate that its alanineglyoxylate aminotransferase activity is not favored over aminobutyrate-pyruvate, b-alanine-pyruvate and dimethylarginine-pyruvate aminotransferase ... (p97) cofactor (p47) Aminoacylase Phosphoglycerate mutase Indolethylamine N-methyltransferase Peroxiredoxin Apolipoprotein A- I Abhydrolase domain containing 14b D-Amino Protein na...

Ngày tải lên: 23/03/2014, 03:20

... Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S: Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil ... cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscri...

Ngày tải lên: 18/06/2014, 22:20

... of adenomatous polyposis coli (APC), somatostatin, carbonic anhydrase and tenascin C in the cerebellum (Figure 1a) and those of lysyl oxidase, carbonic anhydrase 4, enolase 3β and creatine kinase ... sensitive to thyroid hormone and the primary mode of T3 action is a direct influence on cardiac gene expression [20] Increased heart rate (tachycardia) and myocardial contractility...

Ngày tải lên: 09/08/2014, 20:20

... Injection Site Erythema Injection Site Haemorrhage Injection Site Induration Injection Site Pain Localised Oedema Herpes Simplex Sinusitis Urinary Tract Infection Contusion Back pain Myalgia Headache ... Validation of intra-cellular staining after ex vivo stimulation with peptides Before evaluating HBsAg- specific T cells response by intracellular staining to detect cytokines in T cell...

Ngày tải lên: 11/08/2014, 10:23

... polarizing cytokines, it is important to remember that these co-cultures did not include epithelial cells It is likely that epithelial cells also influence the outcome of DC and CD4+ T cell interactions, ... demonstrating that these cells alone produce pro-inflammatory mediators When co-cultured with CD4+ OTII cells, NO2-exposed pulmonary CD11c+ cells promoted the...

Ngày tải lên: 12/08/2014, 11:22

... peptides including LANP, VD and KP in modulating lung inflammation In this report we show that overexpression of VD attenuates airway inflammation in a mouse model of allergic asthma The effects of ... determine airway resistance values and peak values obtained after each MeCh challenge were plotted [16] Modulation of lung inflammation by VD To test the eff...

Ngày tải lên: 12/08/2014, 14:20