Evaluation of thymoquinone for cytotoxic activity against human breast cancer cell lines and tumor xenograft in nude mice

... protein expression of several genes of interest in the tumor tissues was examined and these findings were compared with those from cell line studies The antitumor effect of the combination of TQ ... determining the anticancer activities of TQ and its possible mechanisms of action in breast cancer cells, our next interest was to examine these effects in an animal...

Ngày tải lên: 10/09/2015, 09:09

... 5¢-UCAUCGCAUUCC UUGCAAAdTdT-3¢, antisense strand 5¢- UUUGCAAGGAAUGCGAUGAdTdT-3¢; ERa siRNA #3 sense strand 5¢- GGAGAAUGUUGAAACA CAAdTdT-3¢, antisense strand 5¢- UUGUGUUUCAA CAUUCUCCdTdT-3¢ The transfection ... that miR-22 is frequently downregulated in ERa-positive human breast cancer cell lines and clinical samples In addition, further functional studies showed that E...

Ngày tải lên: 22/03/2014, 21:20

... first report highlighting that the suppression of proliferation, invasion and migration in human breast cancer cell line MDA-MB-231, at least in part, results from silencing of JMJD2A The present ... These data indicated that JMJD2A- specific siRNA silencing mRNA could significantly reduce the levels of JMJD2A protein expression in MDA-MB-231 cells Silencing...

Ngày tải lên: 10/08/2014, 10:21

... the expression of all MMPs known in humans so far by measuring mRNA and protein level in twelve gynecological cancer cell lines commonly used in experimental research We examined cell lines of ... summarized in Additional file 1: MMP expression in gynecological cancer cell lines Methods Cell culture All the cell lines used were described in Table...

Ngày tải lên: 28/03/2014, 14:20

... doi:10.1186/1757-2215-4-17 Cite this article as: Kumar et al.: MicroRNA signature of cis-platin resistant vs cis-platin sensitive ovarian cancer cell lines Journal of Ovarian Research 2011 4:17 Submit your next ... CM: MicroRNA signatures in human ovarian cancer Cancer Res 2007, 67:8699-8707 19 Taylor DD, Gercel-Taylor C: MicroRNA signatures of tumor-derived...

Ngày tải lên: 20/06/2014, 08:20

... Human colon cancer cell lines RKO (ATCC, USA), breast cancer cell line MCF-7 (KCLB, Korea), and normal colon cell line DDC-112 CoN (ATCC) were used RKO and MCF-7 cell lines were cultivated in Dulbecco's ... much information is known about the combined effects of HDAC inhibitors and demethylating agents In this experiment, human colon and breast cancer...

Ngày tải lên: 09/08/2014, 04:21

... ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF7 in vitro Journal of Experimental ... recepter alpha (ER a ), matrix metalloproteinase 9(MMP-9), cyclinD1, and on cancer cells invasion, proliferation and...

Ngày tải lên: 10/08/2014, 10:21

... A, Gray JW: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Cancer Cell 2006, 10:515-527 Genome Biology 2009, 10:R31 http://genomebiology.com/2009/10/3/R31 ... identification of key cell signaling events in the context of cancer Materials and methods Cell lines The complete panel contains 51 breast cancer cel...

Ngày tải lên: 14/08/2014, 21:20

... Despite the availability of therapies targeting estrogen and growth factor signaling pathways, the incidence and mortality of breast cancers have not decline at the same rate as other major causes of ... 36 1.8 Icaritin and cancer cell proliferation 1.8.1 Icaritin and cancer cell proliferation Herba Epimedii is officially listed in China as an herb that p...

Ngày tải lên: 04/10/2015, 17:05

... article as: Mueller et al.: Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®®) in human cancer cell lines Journal of Experimental & Clinical Cancer Research 2011 30:42 Submit ... varying from 0.3 mg/ml to 0.54 mg/ml yielding in a RAA of 1.7-3.3 (Figure 1) Detection of the mode of cell death induced by FWGE in a panel of c...

Ngày tải lên: 10/08/2014, 10:21

... MOLECULE COMPOUNDS AS ANTI- INVASIVE AGENTS ON BREAST CANCER CELLS 22 1.5 OBJECTIVES 24 CHAPTER 2: EVALUATION OF A SERIES OF CHALCONE ANALOGS FOR POTENTIAL ANTI- INVASIVE EFFECT ... and methoxylated chalcones exhibiting anti- invasive properties against breast carcinoma cells, and exposed the NF-κB signaling pathway as a molecular target of chalcones There...

Ngày tải lên: 02/10/2015, 17:14

... estimating the demand for two interdependent infrastructure investments If one is not able to estimate the demand in an accurate way, the true effects and payoff of an infrastructure investment for different ... not pay off since the true demand for the investment is too low 1.1.2 Infrastructure Investments and Region Enlargement If the estimation of the demand...

Ngày tải lên: 23/03/2014, 19:20

... http://www.jneuroengrehab.com/content/3/1/27 In this paper we compare methods for the accurate extraction of the volitional EMG envelope out of the raw dynamic EMG signal A synthesized, well-defined and known EMG signal, served for the ... Several methods were used for evaluation of the success of extraction of the volitional EMG The bas...

Ngày tải lên: 19/06/2014, 10:20

... impact of expanders on the performance of negative plates in lead–acid batteries The resulting discharge and recharge transients show the effect of the expander on the electrode response under ... The use of a miniplate as the electrode, and evaluation of the results in terms of the percentage utilization of NAM, provide a reliable method for selecting the most adequat...

Ngày tải lên: 05/07/2014, 20:21

... impact of expanders on the performance of negative plates in lead–acid batteries The resulting discharge and recharge transients show the effect of the expander on the electrode response under ... The use of a miniplate as the electrode, and evaluation of the results in terms of the percentage utilization of NAM, provide a reliable method for selecting the most adequat...

Ngày tải lên: 05/07/2014, 21:20