Evaluation of thymoquinone for cytotoxic activity against human breast cancer cell lines and tumor xenograft in nude mice

... protein expression of several genes of interest in the tumor tissues was examined and these findings were compared with those from cell line studies The antitumor effect of the combination of TQ ... determining the anticancer activities of TQ and its possible mechanisms of action in breast cancer cells, our next interest was to examine these effects in an animal model Breast tumor xenograft ... number and size of aberrant crypt foci in 1,2-dimethyl hydrazine-induced colon cancer in mice (Gali-Muhtasib et al., 2008b) Oral administration of TQ inhibited forestomach tumor incidence and multiplicity...

Báo cáo khoa học: An estrogen receptor a suppressor, microRNA-22, is downregulated in estrogen receptor a-positive human breast cancer cell lines and clinical samples pptx

... 5¢-UCAUCGCAUUCC UUGCAAAdTdT-3¢, antisense strand 5¢- UUUGCAAGGAAUGCGAUGAdTdT-3¢; ERa siRNA #3 sense strand 5¢- GGAGAAUGUUGAAACA CAAdTdT-3¢, antisense strand 5¢- UUGUGUUUCAA CAUUCUCCdTdT-3¢ The transfection ... that miR-22 is frequently downregulated in ERa-positive human breast cancer cell lines and clinical samples In addition, further functional studies showed that ERa plays an important role in ... candidates or therapeutic targets [10] Breast cancer is one of the most common and prevalent cancers in women and a leading cause of cancerrelated death [11] As in other common cancers, the formation...

báo cáo khoa học: " Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro" pptx

... first report highlighting that the suppression of proliferation, invasion and migration in human breast cancer cell line MDA-MB-231, at least in part, results from silencing of JMJD2A The present ... These data indicated that JMJD2A- specific siRNA silencing mRNA could significantly reduce the levels of JMJD2A protein expression in MDA-MB-231 cells Silencing JMJD2A gene resulted in cell cycle ... suppressor gene ARHI in breast cancer Oncogene 2006, 25:230-239 doi:10.1186/1756-9966-30-90 Cite this article as: Li et al.: Effects of RNA interference-mediated gene silencing of JMJD2A on human breast...

Expression pattern of matrix metalloproteinases in human gynecological cancer cell lines ppt

... the expression of all MMPs known in humans so far by measuring mRNA and protein level in twelve gynecological cancer cell lines commonly used in experimental research We examined cell lines of ... summarized in Additional file 1: MMP expression in gynecological cancer cell lines Methods Cell culture All the cell lines used were described in Table [20-45] and obtained from Cell Lines Service ... other MMPs in at least one of the cell lines For MMP-8, -12 and -21 only very weak mRNA expression could be observed in single cell lines Nine MMPs, which were present in most of the cell lines, were...

báo cáo hóa học:" MicroRNA signature of cis-platin resistant vs. cisplatin sensitive ovarian cancer cell lines" pot

... doi:10.1186/1757-2215-4-17 Cite this article as: Kumar et al.: MicroRNA signature of cis-platin resistant vs cis-platin sensitive ovarian cancer cell lines Journal of Ovarian Research 2011 4:17 Submit your next ... CM: MicroRNA signatures in human ovarian cancer Cancer Res 2007, 67:8699-8707 19 Taylor DD, Gercel-Taylor C: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer ... linked to cis-platin resistance by identifying miRNA differences in cis-platin resistant and cis-platin sensitive cell lines Page of 11 Methods Cell lines and cell culture Human epithelial ovarian...

Báo cáo khoa học: "The combination effect of sodium butyrate and 5-Aza-2''''-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines" pot

... Human colon cancer cell lines RKO (ATCC, USA), breast cancer cell line MCF-7 (KCLB, Korea), and normal colon cell line DDC-112 CoN (ATCC) were used RKO and MCF-7 cell lines were cultivated in Dulbecco's ... much information is known about the combined effects of HDAC inhibitors and demethylating agents In this experiment, human colon and breast cancer cell lines were used to determine the effects of ... methylated in the CCD-112 CoN cell lines (Table 3) XTT results after addition of sodium butyrate and 5-Aza2'-deoxycytidine In the MCF-7 cell line, 87% of the cells survived after radiation alone, 73%...

báo cáo khoa học: "ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro" pptx

... ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF7 in vitro Journal of Experimental ... recepter alpha (ER a ), matrix metalloproteinase 9(MMP-9), cyclinD1, and on cancer cells invasion, proliferation and cell cycle cell in two cell lines were investigated Page of 11 Construction of ... menbrane components One member of this family, MMP-9 was up-regulation in invasive cancers, including breast cancer After silencing of MTA1 gene, we investigated the alteration of tumor cells invasiveness...

Báo cáo y học: " Integrated analysis of breast cancer cell lines reveals unique signaling pathways" pot

... A, Gray JW: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Cancer Cell 2006, 10:515-527 Genome Biology 2009, 10:R31 http://genomebiology.com/2009/10/3/R31 ... identification of key cell signaling events in the context of cancer Materials and methods Cell lines The complete panel contains 51 breast cancer cell lines that have been previously described ... context of breast cancer Traditionally, the site of origin has been one of the primary features with which to classify breast cancers [23-25] The full transcriptional profiles of our cell line...

Dual activation of estrogen receptor a and aryl hydrocarbon receptor by the prenylflavone, icaritin restrict breast cancer cell growth and destabilize estrogen receptor a protein

... Despite the availability of therapies targeting estrogen and growth factor signaling pathways, the incidence and mortality of breast cancers have not decline at the same rate as other major causes of ... 36 1.8 Icaritin and cancer cell proliferation 1.8.1 Icaritin and cancer cell proliferation Herba Epimedii is officially listed in China as an herb that prevents the growth of cancer and has been ... therapy in postmenopausal hormone therapy and recurrence of breast cancer Table shows the risk of breast cancer recurrence in breast cancer survivors after hormone replacement therapy [Figure adapted...

báo cáo khoa học: "Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®) in human cancer cell lines" pot

... article as: Mueller et al.: Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®®) in human cancer cell lines Journal of Experimental & Clinical Cancer Research 2011 30:42 Submit ... varying from 0.3 mg/ml to 0.54 mg/ml yielding in a RAA of 1.7-3.3 (Figure 1) Detection of the mode of cell death induced by FWGE in a panel of cell lines In order to distinguish the mode of cell ... Oxaliplatin and Irinotecan in human colon cancer cell lines The combined drug effect of a parallel exposure to FWGE and either 5-FU, irinotecan or oxaliplatin was assessed in a panel of colon cancer cell...

EVALUATION OF CHALCONES FOR POTENTIAL ANTI INVASIVE PROPERTIES AGAINST BREAST CANCEL CELLS

... MOLECULE COMPOUNDS AS ANTI- INVASIVE AGENTS ON BREAST CANCER CELLS 22 1.5 OBJECTIVES 24 CHAPTER 2: EVALUATION OF A SERIES OF CHALCONE ANALOGS FOR POTENTIAL ANTI- INVASIVE EFFECT ... and methoxylated chalcones exhibiting anti- invasive properties against breast carcinoma cells, and exposed the NF-κB signaling pathway as a molecular target of chalcones Therefore, it warrants ... their anti- invasive effects in breast cancer In this study, we were interested to investigate the anti- invasive properties of chalcones in breast cancer cell models Given that 24 Chapter several chalcones...

EVALUATION OF DEMAND FOR INTERDEPENDENT INFRASTRUCTURE INVESTMENTS doc

... estimating the demand for two interdependent infrastructure investments If one is not able to estimate the demand in an accurate way, the true effects and payoff of an infrastructure investment for different ... not pay off since the true demand for the investment is too low 1.1.2 Infrastructure Investments and Region Enlargement If the estimation of the demand for transportation reflects the true demand, ... The demand for transport services tends to be complementary to the demand for other goods and services Therefore, demand for transportation is normally regarded as a derived demand A derived demand...

báo cáo hóa học: " Evaluation of methods for extraction of the volitional EMG in dynamic hybrid muscle activation" pot

... http://www.jneuroengrehab.com/content/3/1/27 In this paper we compare methods for the accurate extraction of the volitional EMG envelope out of the raw dynamic EMG signal A synthesized, well-defined and known EMG signal, served for the ... Several methods were used for evaluation of the success of extraction of the volitional EMG The basic one was by visual inspection of the approximated signal which, despite not providing information ... scheme of the EMG signal A Processing scheme of the EMG signal The grey blocks designate "Rigid" processing modules and their inclusion was mandatory in the scheme The white blocks designate "Flexible"...

Electrochemical evaluation of additives for lead–acid batteries under high-discharge conditions pps

... impact of expanders on the performance of negative plates in lead–acid batteries The resulting discharge and recharge transients show the effect of the expander on the electrode response under ... The use of a miniplate as the electrode, and evaluation of the results in terms of the percentage utilization of NAM, provide a reliable method for selecting the most adequate expander before producing ... potential of y1.350 V was applied for 360 s and the quantity of charge accepted was measured The charge transient for expander B is shown in Fig The utilization of NAM in three successive discharges under...

Electrochemical evaluation of additives for lead–acid batteries under high-discharge conditions pdf

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