Identification of novel inhibitors against mycobacterium tuberculosis l aspartate a decarboxyalse
Identification of novel inhibitors against mycobacterium tuberculosis l aspartate a decarboxyalse
... strategies 1.5 L- ASPARTATE α-DECARBOXYLASE L- Aspartate α- decarboxylase (ADC, EC 4.1.1.11), encoded by the panD gene, is a lyase and catalyzes the decarboxylation of aspartate to β-alanine, which ... Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis (Mtb) L- aspartate α-decarboxylase PLoS ONE 7, e33521 Sharma R, Florea M, Nau WM and Swaminathan K (2012) Validation ... term toxicity of the lead molecules are evaluated on animals The physiological and biological effects of escalating levels of 15 the lead molecules are observed and how the molecule is absorbed,...
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Báo cáo y học: " Identification of novel conserved functional motifs across most Influenza A viral strains" pps
... regions of influenza a virus polymerase gene segments are critical for efficient viral RNA packaging J Virol 2008, 82:2295-2304 25 Obayashi E, Yoshida H, Kawai F, Shibayama N, Kawaguchi A, Nagata K, ... Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation PLoS One 2009, 4:e5658 Skehel J: An overview of influenza ... in avian strains, followed by human strains, which may reflect the adaptation of influenza virus to the warmer host temperature of avians as compared to swine and humans Identification of functional...
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Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx
... the same conditions, these apparent values can be used for comparison of binding afnities of the inhibitors under study The tting of the binding isotherms of all ve compounds with a binding model ... nitrogen and main and side-chain oxygen atoms of Ala59 and Glu61 of one subunit and with the main chain nitrogen of Asn114Â of the other subunit The contacts of the ribityl chain to His89 and Lys138Â ... al Lumazine synthase from M tuberculosis become increasingly difcult because of the growing antibiotic resistance of M tuberculosis The elucidation of the complete genomes of M tuberculosis and...
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Báo cáo y học: "Identification of novel DNA methylation inhibitors via a two-component reporter gene system" pptx
... to be as potent as 5-Aza in terms of demethylation but with much lower cytotoxicity Azacytidine and 5-Aza have been approved for the treatment of myelodysplastic syndromes by FDA, and they are ... Segura-Pacheco B, Trejo-Becerril C, Perez-Cardenas E, Taja-Chayeb L, Mariscal I, Chavez A, Acu a C, Salazar AM, Lizano M, Dueñas-Gonzalez A: Reactivation of tumor suppressor genes by the cardiovascular ... have been made to search for additional DNA methylation inhibitors with greater potency but low cytotoxicity Procainamide, anti-arrhythmic drug, has emerged as a potential candidate because of...
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Báo cáo y học: "Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin/ NMPRTase for glioma therap" doc
... al.: Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin /NMPRTase for glioma therapy Journal of Clinical Bioinformatics 2011 1:5 Submit your next manuscript ... inhibitor known, for the enzyme The structures provide a basis for understanding substrate specificity, mechanism of enzyme action, and hence provide a framework for design of novel NMPRTase inhibitors ... list for further analysis The result of the virtual screening of the dataset is summarized in Table For selection of potential ligands, analysis of ligand protein contacts for top ranking poses of...
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IDENTIFICATION OF NOVEL SMALL MOLECULE INHIBITORS OF PROTEINS REQUIRED FOR GENOMIC MAINTENANCE AND STABILITY
... all of their love and support throughout the years iii ABSTRACT Sarah C Shuck Identification of novel small molecule inhibitors of proteins required for genomic maintenance and stability Targeting ... (51) 1.5 Inhibition of Proteins Required for Genomic Maintenance and Stability As described in previous sections, maintaining genomic stability is essential to prevent mutations and eventual disease ... disruption of the maintenance of genomic stability has deleterious consequences as seen in the acquisition of mutations and eventual development of disease; however inhibition of genomic stability...
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Báo cáo khoa học: Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection ppt
... In all structures of canonical ACs, i.e mammalian AC, trypanosomal AC and mycobacterial AC Rv1264 the lysine-aspartate couple forms a salt bridge [5,7,26] Even in Rv1900c the asparagine-aspartate ... because the canonical amino acids which define substrate specificity are replaced in a nonconservative manner, glutamine-asparagine instead of lysine-aspartate All mammalian membrane-bound ACs ... product as a class IIIc AC which has a glutamineasparagine pair at the positions defining ATP as a substrate instead of the lysine-aspartate consensus We show that the purified catalytic domain of Rv0386...
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Báo cáo khoa học: Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c pot
... phosphatases may possibly To examine whether MursiF retains kinase activity in spite of the loss of critical residues involved in ATP binding, as observed in our in silico analysis of MursiF WKD (Fig 3A), ... dehydrogenase M avium paratuberculosis MAV_1619 Hypothetical protein Hypothetical Mjls_2718 protein Sensor ResponseHypothetical RsbW RsbV Kinase regulator protein M sp KMS Hypothetical protein MAP2361 Acyl-CoA ... UsfX, and interdomain interactions between its RsbW and RsbV domains also occur [13] The role and mechanism of regulation of the multidomain protein Rv1364c are intriguing, and underline the need...
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Báo cáo y học: "Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach" pdf
... Nagasaki M, Nakayama-Hamada M, Kawaida R, Ono M, et al.: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis Nat Genet ... 327:202-211 Iwaki-Egawa S, Matsuno H, Yudoh K, Nakazawa F, Miyazaki K, Ochiai A, Hirohata S, Shimizu M, Watanabe Y: High diagnostic value of anticalpastatin autoantibodies in rheumatoid arthritis ... Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, et al.: An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases...
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Báo cáo y học: " Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes" ppsx
... meticulously dissected air pouch membranes, we identified several genes relating to innate immunity that were induced strongly by MSU crystals Four of the six factors whose upregulation by MSU crystals ... methods Air pouches Figure 1a outlines the sequence of events of the air pouch experiments Air pouches were raised on the backs of 6- to 8week-old female BALB/c mice (Taconic, Tarrytown, NY, USA) by ... Dalbeth N, Haskard D: Pathophysiology of crystal- induced arthritis In Crystal- Induced Arthropathies Edited by: Wortmann R, Schumacher H, Becker M, Ryan L New York, NY: Taylor & Francis; 2007:239-354...
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Báo cáo y học: "Identification of novel genetic susceptibility loci for Behçet''''s disease using a genome-wide association study" pps
... linkers, amplification of targeted DNA, purification of amplified DNA, labeling, hybridization, and scanning The Affymetrix GeneChip® Human Mapping 500K Array was used Scanning and analysis were performed ... subsequently genotyped in patients with Behçet's disease and controls using a case-control genetic association approach and the TaqMan SNP Genotyping Assays (Applied Biosystems, Foster City, CA, USA) Allele ... Ota M, Katsuyama Y, Yabuki K, Ando H, Shiina T, Palimeris GD, Kaklamani E, Ito D, Ohno S, Inoko H: Sequencingbased typing of HLA-B*51 alleles and the significant association of HLA-B*5101 and...
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Báo cáo y học: "Identification of novel exons and transcribed regions by chimpanzee transcriptome sequencing" pptx
... identified and experimentally validated examples of putative novel exons from five genes (Figures S4, S5, S6 and S7 in Additional file 1) Such exons could possibly add novel coding regions and thereby ... RefSeq genes and numerous novel TRs The vast majority of novel TRs was found within or in the vicinity of known genes and thus extends existing gene models, mainly by adding new exons and 3' UTRs ... and developmental stage [7], we speculate that the observed discrepancy could reflect the different ages of the chimpanzees examined by Blekhman et al and by us considered novel TRs and analyzed...
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Báo cáo y học: "LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cell" pps
... in human alveolar macFigure rophages (AM) LMP-420 inhibits replication of M Tb in human alveolar macrophages (AM) AM were collected by bronchial-alveolar lavage from healthy volunteers and infected ... release of pro-inflammatory cytokines/chemokines, such as TNF and MCP-1, may be beneficial in inhibiting the replication of HIV-1, M Tb, or both The potential advantages of small-molecule, inexpensive, ... significantly higher levels of TNF than attenuated strains and that TNF levels correlated with the ability of the mycobacteria to multiply intracellularly Treatment of infected macrophages with anti-TNF...
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báo cáo khoa học: " Identification of novel maize miRNAs by measuring the precision of precursor processing" ppsx
... component of the transcriptome Science 2005, 309(5740):1567-1569 doi:10.1186/1471-2229-11-141 Cite this article as: Jiao et al.: Identification of novel maize miRNAs by measuring the precision of precursor ... miRNA precursors the location of the new miRNA precursors in maize genome 15 16 Additional file 2: secondary structure of the newly identified miRNA precursors the secondary structure of the newly ... new method of identifying novel miRNAs, by measuring the precision of miRNA processing from their precursors, was employed This method, conceptually proposed by Meyer et al., holds that the precise...
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Từ khóa: evaluation of autofocus functions and automatic identification of tuberculosis mycobacteriumthe use of multiplex pcr and an adapted hplc method for identification of mycobacterium bovis and diagnosis of bovine tuberculosisand there is an immediate need for the development of novel and more effective therapeutic modalities against this deadly diseasemdr and extremely drug resistant tuberculosis xdr in clinical isolates of mycobacterium tuberculosisnovel anti microbial peptides of xenorhabdus origin against multidrug resistant plant pathogensallelopathy of velvetbean determination and identification of l dopa as a candidate of allelopathic substancesidentification detection and molecular characterization of novel monopartite begomovirusesidentification of rease with potential activity against hsv 2 genomephòng bệnh mycobacterium tuberculosiselectrochemical preparation and properties of novelidentification of wh gapsautomatic identification of word translationsidentification of english basenpautomatic identification of provi khuẩn lao mycobacterium tuberculosisBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíBT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ