Identification of novel inhibitors against mycobacterium tuberculosis l aspartate a decarboxyalse

... strategies 1.5 L- ASPARTATE α-DECARBOXYLASE L- Aspartate α- decarboxylase (ADC, EC 4.1.1.11), encoded by the panD gene, is a lyase and catalyzes the decarboxylation of aspartate to β-alanine, which ... Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis (Mtb) L- aspartate α-decarboxylase PLoS ONE 7, e33521 Sharma R, Florea M, Nau...

Ngày tải lên: 09/09/2015, 17:53

... regions of influenza a virus polymerase gene segments are critical for efficient viral RNA packaging J Virol 2008, 82:2295-2304 25 Obayashi E, Yoshida H, Kawai F, Shibayama N, Kawaguchi A, Nagata K, ... Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation PLoS One 2009, 4:e5658 Skehel J: A...

Ngày tải lên: 11/08/2014, 21:22

... the same conditions, these apparent values can be used for comparison of binding afnities of the inhibitors under study The tting of the binding isotherms of all ve compounds with a binding model ... nitrogen and main and side-chain oxygen atoms of Ala59 and Glu61 of one subunit and with the main chain nitrogen of Asn114Â of the other subunit The...

Ngày tải lên: 07/03/2014, 11:20

... to be as potent as 5-Aza in terms of demethylation but with much lower cytotoxicity Azacytidine and 5-Aza have been approved for the treatment of myelodysplastic syndromes by FDA, and they are ... Segura-Pacheco B, Trejo-Becerril C, Perez-Cardenas E, Taja-Chayeb L, Mariscal I, Chavez A, Acu a C, Salazar AM, Lizano M, Dueñas-Gonzalez A: Reactivation of tumor suppressor genes by the ca...

Ngày tải lên: 10/08/2014, 05:21

... al.: Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin /NMPRTase for glioma therapy Journal of Clinical Bioinformatics 2011 1:5 Submit your next manuscript ... inhibitor known, for the enzyme The structures provide a basis for understanding substrate specificity, mechanism of enzyme action, and hence provide a fra...

Ngày tải lên: 10/08/2014, 09:22

... all of their love and support throughout the years iii ABSTRACT Sarah C Shuck Identification of novel small molecule inhibitors of proteins required for genomic maintenance and stability Targeting ... (51) 1.5 Inhibition of Proteins Required for Genomic Maintenance and Stability As described in previous sections, maintaining genomic stability...

Ngày tải lên: 24/08/2014, 11:28

Ngày tải lên: 13/10/2015, 16:41

... In all structures of canonical ACs, i.e mammalian AC, trypanosomal AC and mycobacterial AC Rv1264 the lysine-aspartate couple forms a salt bridge [5,7,26] Even in Rv1900c the asparagine-aspartate ... because the canonical amino acids which define substrate specificity are replaced in a nonconservative manner, glutamine-asparagine instead of lysine-aspartate All mammalian membrane-bound AC...

Ngày tải lên: 07/03/2014, 21:20

... phosphatases may possibly To examine whether MursiF retains kinase activity in spite of the loss of critical residues involved in ATP binding, as observed in our in silico analysis of MursiF WKD (Fig 3A), ... dehydrogenase M avium paratuberculosis MAV_1619 Hypothetical protein Hypothetical Mjls_2718 protein Sensor ResponseHypothetical RsbW RsbV Kinase regulator prot...

Ngày tải lên: 30/03/2014, 02:20

... Nagasaki M, Nakayama-Hamada M, Kawaida R, Ono M, et al.: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis Nat Genet ... 327:202-211 Iwaki-Egawa S, Matsuno H, Yudoh K, Nakazawa F, Miyazaki K, Ochiai A, Hirohata S, Shimizu M, Watanabe Y: High diagnostic value of anticalpastatin autoantibodies in rh...

Ngày tải lên: 09/08/2014, 08:23

... meticulously dissected air pouch membranes, we identified several genes relating to innate immunity that were induced strongly by MSU crystals Four of the six factors whose upregulation by MSU crystals ... methods Air pouches Figure 1a outlines the sequence of events of the air pouch experiments Air pouches were raised on the backs of 6- to 8week-old female BALB/c mi...

Ngày tải lên: 09/08/2014, 10:23

... linkers, amplification of targeted DNA, purification of amplified DNA, labeling, hybridization, and scanning The Affymetrix GeneChip® Human Mapping 500K Array was used Scanning and analysis were performed ... subsequently genotyped in patients with Behçet's disease and controls using a case-control genetic association approach and the TaqMan SNP Genotyping Assays (Applied Biosys...

Ngày tải lên: 09/08/2014, 14:20

... identified and experimentally validated examples of putative novel exons from five genes (Figures S4, S5, S6 and S7 in Additional file 1) Such exons could possibly add novel coding regions and thereby ... RefSeq genes and numerous novel TRs The vast majority of novel TRs was found within or in the vicinity of known genes and thus extends existing gene models, mai...

Ngày tải lên: 09/08/2014, 20:22

... in human alveolar macFigure rophages (AM) LMP-420 inhibits replication of M Tb in human alveolar macrophages (AM) AM were collected by bronchial-alveolar lavage from healthy volunteers and infected ... release of pro-inflammatory cytokines/chemokines, such as TNF and MCP-1, may be beneficial in inhibiting the replication of HIV-1, M Tb, or both The potential advantage...

Ngày tải lên: 10/08/2014, 05:20

... component of the transcriptome Science 2005, 309(5740):1567-1569 doi:10.1186/1471-2229-11-141 Cite this article as: Jiao et al.: Identification of novel maize miRNAs by measuring the precision of precursor ... miRNA precursors the location of the new miRNA precursors in maize genome 15 16 Additional file 2: secondary structure of the newly identified miRN...

Ngày tải lên: 11/08/2014, 11:21