Investigating the superoxide mediated survival pathway in the prostate cancer cell line LNCaP

... result in cell death The delicate redox balance is kept in check, and is often the deciding factor in determining cell fate in these cancer cells 1.6 PROSTATE CANCER Prostate cancer, the cancerous ... classified under the extrinsic and intrinsic pathway The extrinsic pathway involves the direct transduction of an external signal that activates apoptosis T...

Ngày tải lên: 09/09/2015, 17:52

... Role of Superoxide anion in Cancer 55 PROSTATE CANCER 1. 6 .1 1.6.2 1. 6.3 AIM OF STUDY MATERIALS 2 .1. 1 2 .1. 2 2 .1. 3 2 .1. 4 2.2 GROWTH-FACTOR REGULATION OF CELL SURVIVAL 3 .1. 1 3 .1. 2 3 .1. 3 3 .1. 4 3 .1. 5 ... Bad-dependent 11 6 RSK1 is the Bad kinase activated by EGF in LNCaP cells 12 1 iv 3 .1. 8 3 .1. 9 3 .1. 10 3.2 Role of ErbB receptors in EGF- an...

Ngày tải lên: 12/09/2015, 08:18

... SERUM-MEDIATED SURVIVAL IS INDEPENDENT OF MEKERK- AND PI3K-AKT -INDEPENDENT PATHWAY IN LNCAP CELLS Although both EGF and serum inhibited LY-induced apoptosis in LNCaP cells, analysis of survival signaling involved ... PI3K-AKT -INDEPENDENT SURVIVAL PATHWAY(S) IN LNCAP CELLS The PI3K-Akt pathway has been proposed to be the major survival pathway in LNCaP cells due...

Ngày tải lên: 12/09/2015, 08:18

... that the heat shock response is negatively modulated by PARP-1 activation in fibroblasts; therefore siRNA mediated PARP-1 inhibition would lead to augmentation of the heat shock response Material ... H, Salzman AL, Szabo C: Peroxynitritemediated DNA strand breakage activates poly- adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macroph...

Ngày tải lên: 11/08/2014, 03:20

... that the heat shock response is negatively modulated by PARP-1 activation in fibroblasts; therefore siRNA mediated PARP-1 inhibition would lead to augmentation of the heat shock response Material ... H, Salzman AL, Szabo C: Peroxynitritemediated DNA strand breakage activates poly- adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macroph...

Ngày tải lên: 11/08/2014, 06:22

... to bind lipid compounds within the different endolysosomal compartments [23] In this study, we examined whether iron loading of the liver epithelial cell line HepG2 in uenced the expression of ... stress, cell growth and lipid metabolism in the iron loaded HepG2 The results of the study revealed a new link between iron loading and lipid...

Ngày tải lên: 19/02/2014, 16:20

... Identification of eEF1A as a nuclear protein specifically related to the cytotoxicity of GT oligomer in cancer cells In order to identify the nuclear proteins that specifically recognize cytotoxic GT oligomers, ... by cytotoxic GT oligomers and their selective binding to nuclear eEF1A In fact, in normal human lymphocytes no appreciable bi...

Ngày tải lên: 21/02/2014, 00:20

... play a primary role in the differing toxicity of G93ASOD1 and wtSOD1 As long as GCL activity and GCLM are elevated, as in lowG9 3A- tTA cells, motor neuronal cells maintain some antioxidant capacity ... Our model appears to also provide a tool to investigate the effects of chronic exposure to a small amount of G93ASOD1, as seen in the motor neurons of F...

Ngày tải lên: 29/03/2014, 23:20

... Unveiling iodine’s mechanism of action is of crucial importance Verifying the protective effects of iodine in breast cancer pathways will improve our understanding of breast cancer physiology and ... significant increase in mRNA levels (Figures 2B and C) Discussion As the body of evidence builds, the importance of iodine on the maintenance of healthy breas...

Ngày tải lên: 08/08/2014, 17:20

... mechanism in CS-induced emphysematous lungs In conclusion, CS downregulates VEGFR2-mediated cell survival signaling pathways in rat lungs in vivo (Fig 8), however, these alterations were unable to induce ... downstream signaling leading to apoptotic cell death in lung has not been studied Therefore, we hypothesized that CS regulates VEGFR2-mediated survival signalin...

Ngày tải lên: 11/08/2014, 08:22

... INHIBITION OF MISFOLDED N- COR INDUCED SURVIVAL PATHWAY IN APL BY ARTEMISININ YEO HUI LING ANGIE (B.Sc.(Hons.), NTU) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF MEDICINE ... protein (Hsp) 70 chaperone family It consists of an N- terminal ATPase and a C-terminal substrate binding domain Conformational changes in GRP78 regulate its bind...

Ngày tải lên: 12/10/2015, 17:35

... the siRNA sequence that is most effective in knocking down DLEC1 in HCT116 cell line We then knocked down DLEC1 in the HCT116 cell line using this siRNA 72 hours after the transfection, the cells ... that it was a candidate tumor suppressor gene The over-expression of DLEC1 in hepatocellular carcinoma (HCC) cell lines such as HepG2 and SK-Hep-...

Ngày tải lên: 16/10/2015, 15:37

... Forskolin up-regulates metastasis-related phenotypes and molecules via protein kinase < /b> B, but not PI-3K, in H7721 human hepato-carcinoma cell line Mol Cell Biochem (in press) 37 Giancotti, F.G & Mainiero, ... value in S-PKB and ASPKB transfected cells, respectively After insulin treatment, PKB activity was almost doubled in the mock and S-PKB/ H7721 cells...

Ngày tải lên: 21/02/2014, 00:20

... -response relationships in a human glioma cell line (BMG-1) show that disulphonated aluminum phthalocyanine (AlPcS2) photodynamically induces loss of cell survival (assayed by clonogenicity) in a concentration ... 72:210-216 Gupta S, Dwarakanath BS, Muralidhar K, Jain V: Cellular uptake, localization and photodynamic effects of haematoporphyrin derivative in hum...

Ngày tải lên: 18/06/2014, 16:20

... and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant Proc Natl Acad Sci USA ... infection, demonstrating an important role of clathrin for RSV entry [9] Proteins that are internalized through the clathrin-mediated pathway usually bear the well characterized sorting signa...

Ngày tải lên: 20/06/2014, 01:20