INVESTIGATING THE HOST IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS THE ROLES OF ANNEXIN a1 PROTEIN AND CLEC9A+ DENDRITIC CELLS

... INVESTIGATING THE HOST IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS: THE ROLES OF ANNEXIN A1 PROTEIN AND CLEC9A+ DENDRITIC CELLS KOH HUI QI VANESSA (B Sc (Life Sciences, Hons.), NUS) A THESIS ... variety of immune cells, and the role of CLEC9A+ dendritic cells (DCs), which includes CD103+ migratory DCs in the lung and CD8+ DCs in the...

Ngày tải lên: 09/09/2015, 08:20

... 2008; Aning, Turkson, and Asuming-Brempong 2008; Obi, Oparinde, and Maina 2008; Omiti and Okuthe 2008) Therefore, information regarding the role of poultry in the livelihoods of small-scale poultryproducing ... Birol, and D Roy 2010 Investigating the role of poultry in livelihoods and the livelihoods impact of HPAI in Nigeria DFID-funded proje...

Ngày tải lên: 21/02/2014, 01:20

... histidine residues in PETN reductase inferred to be involved in ligand binding and counterpart residues in related enzymes and also the location of the tyrosine residue implicated as proton donor in ... unusual in having two histidine residues (rather than the His-Asn pair seen in OYE, MR and some of the other member proteins; Fig 1B) in the active...

Ngày tải lên: 20/02/2014, 02:21

... overlapping sites Given the large number of potential binding sites in a localized region of 3' UTR, the increased repression of multiple pairs of binding sites can be explained by having more binding ... binding sites available to bind to, which in turn means a greater probability of binding and thus repression In contrast, the reduced repression of a sing...

Ngày tải lên: 14/08/2014, 08:20

... 17 1. 9 Cooperative and distinct functions of HDAC1 and 18 1. 9 .1 Redundancy of HDAC1 and HDAC2 functions 18 1. 9 .2 Distinct functions of HDAC1 and HDAC2 19 1. 10 Inhibition of ... 20 1. 11 Biological effects and mechanisms of action of HDAC inhibitors 20 1. 11. 1 Apoptosis 20 1. 11. 2 Growth arrest 22 1. 11. 3 Mitotic disruption and autophagy .....

Ngày tải lên: 10/09/2015, 08:27

... substantial loss in nicotinic receptors in cortex and striatum According to the growing amount of findings, accumulation of amyloid plaques which are the baseline indicator in the brain for AD is interfered ... in response to acute nicotine exposure It furthermore suggests the strong synchronization of hippocampal neural network in the mid phase (ga...

Ngày tải lên: 19/06/2014, 08:20

... REVIEW Open Access Wallerian degeneration: the innate-immune response to traumatic nerve injury Shlomo Rotshenker Abstract Traumatic injury to peripheral nerves results in the loss of neural ... is given to the orchestration of these events with respect to their timing and magnitude, and to the identity of the cells that produce them Timing differs between sp...

Ngày tải lên: 19/06/2014, 22:20

... of brain injury The significant findings of increased T cell infiltrate into the injury site, increased levels of IL-2, prolonged neuronal death surrounding the injury site and increased numbers ... infiltrating the injury site in wild type and MT-I/II -/- mice Analysis of the numbers of leukocytes in circulation in the days following brain injury...

Ngày tải lên: 19/06/2014, 22:20

... determined by intracellular (IC) staining of lines PMA (phorbol 12-myristate 13-acetate)/ionomycin activated T cells (a) We detected interferon (IFN)-γ staining but no interleukin (IL)-4 staining ... of a more generalised immune reactivity to extracellular matrix proteins in SSc Laminin and, less often, type IV collagen can induce proliferation of SSc lymphocytes [16] Autoanti...

Ngày tải lên: 09/08/2014, 08:22

... deviation of the cytokine response, caused either by decreased Th1-type cytokines and/ or by enhanced Th2-type cytokines leading to the regression of an autoimmune disease, is reminiscent of other ... secretion of anti-inflammatory cytokines over proinflammatory cytokines in response to Bhsp65 To test and compare the T cell proliferative and cytokine respons...

Ngày tải lên: 09/08/2014, 10:20

... volunteers in Rio de Janeiro (Brazil) after oral vaccination with M bovis BCG Moreau RDJ Methods Volunteers and skin testing Healthy subjects aged 18–50 years were recruited who gave no history of pulmonary ... dose of oral vaccine and had been immunised in infancy via the oral and intradermal routes respectively, displayed an altered humoral immune response...

Ngày tải lên: 11/08/2014, 10:23

... Figure Cytokine response to chronic aspiration of gastric fluid Cytokine response to chronic aspiration of gastric fluid Cytokine levels were evaluated in the bronchoalveolar lavage (BAL) fluid ... model of chronic aspiration described herein, chronic aspiration can initiate an inflammatory response consisting of macrophages and T cells and characterized...

Ngày tải lên: 12/08/2014, 15:21

... failure to clear the organism [6,7] In the initial phase of infection, Listeria binds to splenic macrophages and is internalized; Listeria produces products that activate nuclear factor-kappa B and ... Pamer [5], in the first few days of Listeria infection, the innate response is critical for early bacterial clearance and host survival The adaptive response...

Ngày tải lên: 13/08/2014, 10:20

... Critical Care Vol 13 No Christaki implications of endotoxin tolerance continue to be elusive [4] Although endotoxin tolerance has been implicated in increased susceptibility to secondary infections, ... Arnalich F, LópezCollazo E: Inflammatory responses associated with acute coronary syndrome up-regulate IRAK-M and induce endotoxin tolerance in circulating monocytes J Endotoxin Res 20...

Ngày tải lên: 13/08/2014, 20:21

Ngày tải lên: 14/02/2014, 07:20