Functional role of low density lipoprotein receptor related protein 5 and 6 in alzheimers disease

... available on the autoimmunity to LRP2 in humans Therefore, we have investigated the autoimmunity to LRP2 in systemic autoimmune diseases, focusing on prevalence, autoepitope distribution, clinical significance, ... Tohma S, Inoue T, Yamamoto K, Nishioka K, Kato T: Autoantibodies to T cell costimulatory molecules in systemic autoimmune diseases J Immunol 1999, 1 62: 4 328 -4335 Yu X, Matsui T, Otsuka M, Sekine ... human LRP2 were obtained by RT-PCR They were then expressed as a maltose-binding protein (MBP) fusion protein EGF, epidermal growth factor; LDL, low-density lipoprotein without anti-LRP2 autoAbs...

... bound 64 10% of all complexes, and the binding of variant complexes always varied less than 20% from the binding of the wild-type complex Binding of the uPAPAI-1 complex to the receptors was ... between the uPA PAI-1 complex and the endocytosis receptors In the model of the complex between PAI-1 and the uPA SPD, constructed from the 3D structure of the a1-PItrypsin complex, as determined by ... sorLA [11] These receptors mediate endocytosis of uPAPAI-1 complex accumulated on the cell surface by binding to the urokinase-type plasminogen activator receptor (uPAR), whereas endocytosis directly...

... Landsberger et al.: Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal microcirculation in experimental endotoxemia in rats Critical ... lipoprotein receptor-1 resulted in a reduction of endotoxininduced intestinal leukocyte adhesion Therefore, this receptor may represent a novel target for the modulation of the inflammatory response within ... response within the microcirculation in sepsis Key messages • Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is involved in leukocyte recruitment • Systemic leukocyte activation...

... resulting in the accumulation of both unmodified cholesteryl esters and glycated apoB in the cells The rate of removal of the latter species is slow, with only 20–30% of the glycated protein being ... although the concentrations of these materials present in the artery wall, and in atherosclerotic lesions, are unknown The role of glycation and the two facets of glycoxidation in generating modified ... Klein RL & Virella G (1996) Modification of lipoproteins in diabetes Diabetes Metab Rev 12, 69–90 10 Tomkin GH & Owens D (2001) Abnormalities in apo B-containing lipoproteins in diabetes and atherosclerosis...

... controls Protective effect of dietary curcumin, capsaicin and their combination on iron -induced LDL oxidation in vivo and copper -induced LDL oxidation in vitro Oxidation of LDL observed in iron(II) ... Manjunatha and K Srinivasan Protective effect of dietary curcumin, capsaicin and their combination on iron -induced LDL oxidation in vivo and copper -induced LDL oxidation in vitro Male Wistar rats (eight ... compilation ª 2006 FEBS 4529 Health protective effects of curcumin and capsaicin H Manjunatha and K Srinivasan Table Effect of dietary curcumin and capsaicin on iron(II) -induced (in vivo) and copper-induced...

... further investigate the role of the SEA domain in cleavage of membrane-tethered mucins we carried out site-directed mutagenesis of the FRPG ⁄ SVVV site and evaluated hybrid mucins in which the SEA ... previously The fragments were then cloned into the SpeI ⁄ XhoI sites of the polylinker in MUC1FDTR The remaining portions of the polylinker introduced leucine and valine residues N-terminal to the MUC3 ... SEA modules and mucin cleavage T Palmai-Pallag et al Table Conservation of the G ⁄ S cleavage site sequence in MUC1 from several species, other membrane-tethered mucins and SEA domain containing...

... regulators in S coelicolor Fig Comparative alignment of domains (DNA–protein interaction), (dimerization and metal binding) and (containing a nonconserved amino acid stretch), of the Streptomyces coelicolor ... on DNAÆprotein interaction and of domain in the protein dimerization and metal binding (see the Discussion) There are important differences between DmdR1 and DmdR2 proteins in a Pro- and Ala-rich ... existence, in S coelicolor, of a gene(s) encoding an iron-regulator of the DmdR family We report, in this article, the presence of two different genes – dmdR1 and dmdR2 – in the genome of S coelicolor, ...

... portfolio of cell ECM interaction assays indicated roles for DP9 in cell adhesion, in vitro wound healing, cell migration and apoptosis, and for DP8 in wound healing, cell migration and apoptosis enhancement ... be to retain expressing cells in the tumor and in sites of expression in the injured liver It would be interesting to localize the DP9- expressing cells in tumors and cirrhotic liver The biological ... relatedness, DP8 and DP9 exert these differences in their cellular effects Therefore, these two proteins are likely to have different functions and ligands These data indicate that DP8 and DP9 have...

... of the reliability of the glutaraldehyde test to determine the level of gamma globulin in the serum of foals and the suitability of this test in practice for the control of colostrum intake in ... adding equal amounts of fresh blood and glutaraldehyde in a test tube, mixing by slowly turning the test tube and visually observing and noting the time re- Glutaraldehyde test of in ammatory disease ... acts then as an indicator for further laboratory analysis of blood to determine chronicity and etiology of the disease If the test is negative, the disease is most likely acute or the systemic in ammatory...

... half-time for binding to the Characterization of the binding of PCSK9 to intact cells Fig Nonlinear regression and Scatchard analyses of binding- inhibition data (A) Inhibition of [125I]TC-PCSK9 (2.5 ... binding to HepG2 cells To determine whether the kinetics of binding of PCSK9 to HepG2 cells can be described as a simple bimolecular reaction, the kinetics of [125I]TC-PCSK9 and [125I]TC-PCSK9-D374Y ... [125I]TC-PCSK9 binding by unlabeled wild -type PCSK9 (C) Inhibition of [125I]TCPCSK9-D374Y (1 lgÆmL)1) binding to HepG2 cells (9. 2 9. 8 · 105) by increasing concentrations of unlabeled PCSK9-D374Y Error...

... FNIII domains of gp130 are therefore assumed to be arranged in such a way that the C-terminal parts of the membrane-proximal domain D6 are positioned in close vicinity to each other In analogy, ... correct spacing and orientation of the cytoplasmic parts of the receptors for signalling An exchange of gp130 D6 with a domain that does not allow interactions with the corresponding domain of the ... to the membrane, resulting in the inability of the receptor chains to form an active receptor dimer Additionally, the membrane-proximal domains can act as contact sites between the signal transducing...

... endomorphins on huLDL oxidation Table Kinetic parameters for the Cu2+-induced peroxidation of LDL and its inhibition by endomorphins and GSH The reaction conditions and the initial concentration of the ... the control the inhibition period the rate of the absorbance increase became faster, which is close to the original rate of propagation, demonstrating the exhaustion of the antioxidant The kinetic ... 234 nm increased fast with time upon Cu2+-initiation, indicating depletion of the endogenous antioxidants and fast peroxidation of LDL The change in absorbance was inhibited by addition of EM1...

... also be involved in the pro-oxidant action of urate Interestingly, at high Cu2+ concentration, in the presence of 0.5 lM quercetin and 10 lM urate, the LDL oxidation measured in terms of MDA and ... suppose that in the absence of quercetin the prooxidant activity of urate masks its antioxidant activity as mentioned above, whereas, in the presence of quercetin, the pro-oxidant activity of urate ... powerful antioxidant interaction of quercetin and urate can be partially explained by the interception of reactive species, chelation of transition metal ions and/ or regeneration of urate from...

... study [57], the already observed pro-oxidant activity of urate [58] It is unlikely that the pro-oxidant activity of urate is due to the reaction of urate with O2 , as little urate is destroyed in ... relating Cu2+ redox change to the initiation of LPO in LDL are not yet clearly established [40] In the presence of pre-existing traces of hydroperoxides both Cu2+ and Cu+ may induce LPO according ... 2002 Urate in copper-induced LDL oxidation (Eur J Biochem 269) 5477 Fig Kinetic proles of MDA (A,C) and of conjugated dienes (B,D) formation in LDL oxidation induced by 175 lM (A,B) or lM of Cu2+...