hepatic secretion of very low density lipoprotein

... G.F (1990) Assembly and secretion of very- low- density lipoprotein Biochem J 268, 1–13 Rusinol, A., Verkade, H & Vance, J.E (1993) Assembly of rat hepatic very low density lipoproteins in the endoplasmic ... R., Voshol, P.J., Hofker, M.H., van Dijk, K.W., Havekes, L.M & Kuipers, F (1999) Apolipoprotein E participates in the regulation of very low density lipoprotein- triglyceride secretion by the liver ... Origin of hepatic verylow -density lipoprotein triacylglycerol: the contribution of cellular phospholipids Biochem J 320, 673–679 30 Yang, L.Y., Kuksis, A., Myher, J.J & Steiner, G (1995) Origin of...

Ngày tải lên: 23/03/2014, 21:20

... Andreasen PA (1997) Specicity of serine proteinase serpin complex binding to very- low- density lipoprotein receptor and alpha2macroglobulin receptor low- density- lipoprotein- receptor-related protein ... to the endocytosis receptors alpha2-macroglobulin receptor low- density lipoprotein receptor-related protein and very- low- density lipoprotein receptor involves basic residues in the inhibitor ... residues in the 37-loop and 60-loop of the SPD of uPA are part of the ligand receptor interface Fig Effect of Ala substitutions of uPA residues on the binding of the uPAPAI-1 complex to VLDLR,...

Ngày tải lên: 30/03/2014, 10:20

... [koff] of 0.0009 ± 0.00012 min)1 (n = 3), which corresponds to a half-time of dissociation of 770 Lowering the pH of dissociation medium to 6.2 also led to monophasic and slow dissociation of ... the low density lipoprotein (LDL) receptor pathway A lattice model for LDL binding J Biol Chem 266, 19296– 19302 Hwang J & Menon KM (1983) Characterization of low density and high density lipoprotein ... Mousavi et al Characterization of the binding of PCSK9 to intact cells levels of plasma LDL cholesterol, whereas loss -of- function mutations are associated with low levels of plasma LDL cholesterol...

Ngày tải lên: 14/02/2014, 14:20

... core of the particle from lysosomal esterases, or that impaired lipolysis of LDL lipids may block proteolysis of apoB [36] This may arise as a result of the failure of hydrophobic regions of apoB, ... concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxidedependent pathway J Clin Invest 94, 771–778 16 Baynes JW & Thorpe SR (1999) Role of oxidative stress ... Davies MJ & Dean RT (2003) Glycation and glycoxidation of low- density lipoproteins by glucose and low molecular weight aldehydes: formation of modified and oxidised proteins Eur J Biochem 270, 3572–3582...

Ngày tải lên: 19/02/2014, 02:20

... (1993) Inhibition of oxidation of human low- density lipoprotein by phenolic substances in red wine Lancet 341, 544–547 Miyagi Y, Miwa K & Inoue H (1997) Inhibition of lowdensity lipoprotein oxidation ... volume of 10% trichloroacetic acid (TCA) followed by centrifugation To mL of the supernatant was added 300 mg of NaCl and 0.75 mL of butanol The supernatant was made alkaline by the addition of 0.1 ... marked elevation in the activity of these enzymes The extent of elevation in the activities of these enzymes, which are indicators of hepatic injury, was generally lower in various spice principles-fed...

Ngày tải lên: 08/03/2014, 08:20

... activity of endomorphins is not dependent on opioid receptors Very probably the neuroprotective effects of endomorphins result from a combination of the different modes of action In the case of Cu2+-induced ... AAPH-induced apoB fragmentation (Fig 7B) On the basis of the intensity of bands, the protective activity follows the sequence of EM1 > GSH > EM2 Inhibition of REM by EM1 and EM2 Using the same sample solutions ... intensity of bands was noted with the addition of 10, 20 and 40 lm EM1 (Fig 6A, lane 3–5) Treatment of apoB with 40 lm EM1, EM2 and GSH in the presence of 10 lm Cu2+ decreased the extent of apoB...

Ngày tải lên: 23/03/2014, 10:21

... Dirks, M (1989) Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation ... approaches to low density lipoprotein oxidation: whys, wherefores and pittfalls Free Radic Res 25, 285–311 Halliwell, B (1995) Oxidation of low density lipoproteins: questions of initiation, ... Flavonoids and urate in copper-induced low- density lipoprotein oxidation (Eur J Biochem 271) 1999 pro-oxidant effects of urate in copper-induced low- density lipoprotein oxidation Eur J Biochem 269,...

Ngày tải lên: 23/03/2014, 12:20

... values of 3–4 MG-mediated oxidation of LDL Lipid oxidation LDL was incubated with a wide range of MG concentrations (10 lM)100 mM) in both the absence and presence of low concentrations of added ... absence of Cu2+; for 10 and 100 mM GA loss of Trp was significant at day, with higher loss of Trp at this time point occurring in the presence of 100 mM GA For the lower concentrations of GA, losses ... below the lower threshold of 5–6 postulated by the these workers, and hence the absence of any stimulatory effect of glucose cannot be ascribed to a saturation effect This marginal effect of...

Ngày tải lên: 31/03/2014, 01:20

... Dirks, M (1989) Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation ... approaches to low density lipoprotein oxidation: whys, wherefores and pitfalls Free Radic Res 25, 285311 40 Halliwell, B (1995) Oxidation of low density lipoproteins: questions of initiation, ... presence of urate suggesting the involvement of O2 In support of the involvement of O2 , we observed the reduction of ferricytochrome c It may be suggested that following Cu+ formation, reduction of...

Ngày tải lên: 31/03/2014, 08:20

... levels of high -density lipoprotein- cholesterol and autoantibody titers against oxidized low- density lipoprotein Correlation lipoprotein- cholesterol and autoantibody titers against oxidized low- density ... against oxidized low- density lipoprotein between serum levels of high -density lipoprotein (HDL)-cholesterol and autoantibody titers against (a) oxidized low- density lipoprotein in the propagation ... oxidized low- density lipoprotein in the propagation phase 0.029 0.005–0.171 0.000 Antibodies against oxidized low- density lipoprotein in the decomposition phase 0.034 0.008–0.152 0.000 Plasma lipoprotein...

Ngày tải lên: 09/08/2014, 10:20

... IL: interleukin; IVM: intravital fluorescence microscopy; LDL: low- density lipoprotein; LOX-1: lectin-like oxidized low- density lipoprotein receptor-1; Landsberger et al Critical Care 2010, 14:R223 ... oxidized low- density lipoprotein receptor-1 Proc Natl Acad Sci USA 2000, 97:360-364 Oka K, Sawamura T, Kikuta K, Itokawa S, Kume N, Kita T, Masaki T: Lectinlike oxidized low- density lipoprotein ... binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide...

Ngày tải lên: 14/08/2014, 07:21

... role of Wnt co-receptors low density lipoprotein receptor-related protein (LRP) and LRP6 has yet to be established Thus, the overall goal of this study is to explore the functional role of LRP5 ... immunoprecipitation LCM control L-cell conditioned medium LDL low density lipoprotein LOAD late-onset Alzheimer's disease LRP low density lipoprotein receptor-related protein L-Wnt-3a cells L-cells ... OF PUBLICATIONS AND PRESENTATIONS Publications and manuscripts in preparation: Zhang L, Ong WQ, Ee PL Apolipoprotein E4 disrupts normal mitochondrial dynamics through binding to low- density lipoprotein...

Ngày tải lên: 09/09/2015, 08:16

... surface of the sphere The major types of lipoproteins includes chylomicrons, very low density lipoproteins (VLDL), low density lipoproteins (LDL), lipoprotein Lp(a) and high density lipoproteins ... absence of Chlamydia pneumoniae, and low density lipoprotein Introduction The second model consists of human macrophage U937 cell line and low density lipoprotein, after addition of low density lipoprotein ... Introduction of all three main components, of which are Chlamydia pneumoniae, low density lipoprotein and macrophage; and not due to Chlamydia pneumoniae alone In the fourth model, low density lipoprotein...

Ngày tải lên: 03/10/2015, 11:36

... et al Figure Map of low- density- lipoprotein- receptor-related protein (LRP2) Six gene fragments that, with overlaps, covered approximately one-third of the extracellular region of human LRP2 were ... the LDLR domains, which were thought to bind various ligands such as apolipoprotein Eβ very- low- density lipoproteins, lactoferrin, and aprotinin [17] (Fig 1) We divided the region with 1273 amino ... with low density lipoprotein receptor-related protein in systemic autoimmune diseases J Immunol 2001, 166:1360-1369 Hussain MM: Structural, biochemical and signaling properties of the low- density...

Ngày tải lên: 09/08/2014, 01:21

... translocation Identification of the location of functional elements of the PA pore from electron microscopic characterization of ND embedded PA represents an innovative use of ND technology g VDAC-1 ... solubilization, transport and delivery of hydrophobic bioactive molecules Recent success in the design and production of targeted-ND offer a means to expand the capability of this approach [26] Amphotericin ... facilitates diagnosis, choice of therapy as well as assessment of the effectiveness of a given intervention The utility of MRI is significantly enhanced by the use of paramagnetic ions [47] A popular...

Ngày tải lên: 11/08/2014, 00:22

... Table 4.2 (Pa-s)-1 ρ density of the reaction mixture (kg/m3) ρJ density of the jacket fluid (kg/m3) ρM monomer density (kg/m3) ρr reduced density Subscripts b β-scission of a secondary radical ... VJ,i flow rate of jacket fluid in ith jacket (m3/s) VM specific volume of monomer (kg/m3) Vp specific volume of polyethylene (kg/m3) v velocity of the reaction mixture (m/s) vJ,i velocity of coolant ... OPTIMIZATION OF AN INDUSTRIAL, LOW- DENSITY POLYETHYLENE REACTOR NAVEEN AGRAWAL (B.Tech, Indian Institute of Technology, Roorkee, India) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...

Ngày tải lên: 12/09/2015, 08:20

... inhibition of proliferation of VSMC, which is mechanistically linked to a KLF4-induced enhancement of the expression of the tumour suppressor gene p53 [5] Because of the important roles of KLF4 ... with siRNA of KLF4 The relative values of all results were determined and expressed as mean ± standard error of the mean of three experiments in duplicate *P < 0.05 siRNA expression of KLF4 in ... al tion of China (30900623), and the Doctoral Fund of Ministry of Education of China (Fund for New Teacher, 20090162120020) References Dang DT, Pevsner J & Yang VW (2000) The biology of the mammalian...

Ngày tải lên: 18/02/2014, 04:20

... types of examinations Preincubation of the cells with LPS Re (30 at 37 °C) and following addition of HDL, preincubation of the cells with HDL and subsequent addition of LPS Re, and incubation of ... types of experiments with LPS Re and HDL have been carried out Preincubation of the cells with LPS Re (30 at 37 °C) and following addition of HDL, preincubation of the cells with HDL and following ... [LPS]/[PMB] weight ratio of : 0.24, PMB alone causes a drastic fluidization of LPS, while HDL leads to a rigidification of LPS at a weight ratio of [LPS]/[HDL] : 1.5 (Fig 4) Addition of HDL to the preincubated...

Ngày tải lên: 17/03/2014, 10:20

... High -density lipoprotein (HDL) cholesterol levels are a strong inverse predictor of cardiovascular events However, it is not clear whether this association is maintained at very low levels of low- density ... triglyceride levels at month of the trial, and had higher concentrations of apolipoprotein A-I the presence or absence of a history of diabetes, (a structural component of HDL) and lower plasmyocardial ... therapeutic targets independent of the lowering of LDL cholesterol levels However, it could also be argued that if LDL cholesterol levels are reduced to very low levels, low HDL cholesterol levels...

Ngày tải lên: 27/06/2014, 00:20

... clinical diagnosis of a painful heel spur (tenderness of the calcaneus) - limitation of the painless walking distance - duration of symptoms more than six months - radiological proof of heel spur - ... of the models discussed are: Improvement of blood perfusion in the tissue due to an influence of radiation on the endothelium, release of cytokines and enzymes, influence on the local parts of ... of a linear accelerator, they noticed a frequency of pain relief of 69% [4] The same author group published a prospective randomized trial recently [30] comparing the effect of a total dose of...

Ngày tải lên: 09/08/2014, 09:22